This page lists 54 cooling system parts for the 2021 Audi S4, across 15 part types, covering both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged. Every part shows its brand, manufacturer part number and fitment notes.
The cooling system system on the 2021 Audi S4 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (15 parts), Water Pump (10 parts) and Temperature Sender / Sensor (6 parts). The other 12 part types cover the remaining 23 parts.
The 2021 Audi S4 was sold with both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged. 42 parts fit every engine; the other 12 are engine-specific. Each part shows which engine(s) it fits.
26 brands supply cooling system parts for the 2021 Audi S4, led by PRESTONE (5 parts), PEAK (4 parts) and VEMO (4 parts), plus 23 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 Audi S4. 9 parts have it, including PRESTONE AF3100 (Coolant / Antifreeze) and UAC FA50946C (Radiator Fan Assembly). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 S4 engines | AF3055 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 S4 engines | AF3100 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Popular Fits: all 2021 S4 engines | 719009 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Multi-Vehicle Yellow1 Gallon | View on Amazon |
| PEAK Fits: all 2021 S4 engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Blue Mountain Long LifeAll Vehicle | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 S4 engines | AF2100 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 S4 engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 S4 engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: all 2021 S4 engines | AF6510 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | MAX European Violet1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 S4 engines | AFMAX | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AISIN Fits: all 2021 S4 engines | ACE010 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | VioletSi-OAT | View on Amazon |
| PEAK Fits: all 2021 S4 engines | PEV1GAL | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | OET European Extended Life Violet1 Gallon | View on Amazon |
| PENTOSIN Fits: all 2021 S4 engines | 8114306 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Pentofrost E1 Gallon | View on Amazon |
| PENTOSIN Fits: all 2021 S4 engines | 8113106 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Pentofrost E1.5 Liters | View on Amazon |
| PENTOSIN Fits: all 2021 S4 engines | 8113206 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Pentofrost E5 Liters | View on Amazon |
| VALVOLINE Fits: all 2021 S4 engines | 904683 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | HT-12 Pink1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
15 Coolant / Antifreeze parts are listed for the 2021 Audi S4, from PRESTONE, PEAK, PENTOSIN and 2 other brands. PRESTONE AF3100 carries the "Popular" badge. All of them fit every engine offered in the 2021 S4.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, PRESTONE, VALVOLINE and PEAK supply 3 parts: the catalog's value-priced group. A representative part number is PRESTONE AF3100.
The Premium section lists 5 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 6 options from PENTOSIN, AISIN, PEAK and 1 other brand — built to original-equipment specification. AISIN ACE010 is listed in this group.
Coolant Hose Flange Plug
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ÜRO PARTS Fits: all 2021 S4 engines | 357121140 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Plug Kit with Plug and O-Ring | View on Amazon |
This table covers the Coolant Hose Flange plugs. Typical signs include a leak at the drain or glow-plug hole, or a plug that has rounded off. Replace the crush washer and torque to the spec in the notes.
One part is listed for the 2021 Audi S4 — ÜRO PARTS 357121140.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: all 2021 S4 engines | EPT0271 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | without CAP | View on Amazon |
| VAICO Fits: all 2021 S4 engines | V105349 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
2 Coolant Reservoir parts for the 2021 Audi S4 come from 2 brands — REIN and VAICO. Every part fits both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged.
Listed part numbers: REIN EPT0271 and VAICO V105349.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: all 2021 S4 engines | T111 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Standard | View on Amazon |
| ÜRO PARTS Fits: all 2021 S4 engines | 4M0121321Q | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
2 Coolant Reservoir Cap parts for the 2021 Audi S4 come from 2 brands — MOTORAD and ÜRO PARTS. Every part fits both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged.
Listed part numbers: MOTORAD T111 and ÜRO PARTS 4M0121321Q.
Intercooler
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: 3.0L V6 Supercharged | 2711414 | 🇲🇽 MX | View on Amazon | |
| TECHPRO Fits: 3.0L V6 Turbocharged | AU3012113 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TYC Fits: 3.0L V6 Turbocharged | 18105 | 🇺🇸 US | View on Amazon |
This table covers the intercoolers that cool turbo or supercharger charge air.
3 Intercooler parts are listed for the 2021 Audi S4, from GPD, TECHPRO and TYC.
Listed part numbers: GPD 2711414, TECHPRO AU3012113 and TYC 18105.
Radiator
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE Fits: 3.0L V6 Turbocharged | CR960000S | 🇺🇸 US | Brazed cooling fins | View on Amazon |
| NISSENS Fits: 3.0L V6 Turbocharged | 606578 | 🇺🇸 US | Brazed cooling fins | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
2 Radiator parts are listed for the 2021 Audi S4, from MAHLE / CLEVITE and NISSENS.
This group includes MAHLE / CLEVITE CR960000S and NISSENS 606578.
Radiator Fan Assembly
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: all 2021 S4 engines | 2812266 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon | |
| VEMO Fits: all 2021 S4 engines | V15011943 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Right400W | View on Amazon |
| VEMO Fits: all 2021 S4 engines | V15011942 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Fits Left400W | View on Amazon |
| VEMO Fits: all 2021 S4 engines | V15011946 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| UAC Popular Fits: all 2021 S4 engines | FA50946C | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon |
This table covers the fan assemblies (and clutches, where listed) that pull air through the radiator.
5 Radiator Fan Assembly parts for the 2021 Audi S4 come from 3 brands — VEMO, GPD and UAC. The "Popular" part is UAC FA50946C. Every part fits both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged.
The Economy section: 4 options from VEMO and GPD. GPD 2812266 is listed in this group.
Standard Replacement: 1 part, from UAC. A representative part number is UAC FA50946C.
This group includes UAC FA50946C, GPD 2812266 and VEMO V15011943 and the remaining parts above.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Fits: 3.0L V6 Turbocharged | SK621318 | 🇺🇸 US | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
One part is listed for the 2021 Audi S4 — SKP SK621318.
Radiator Insulator
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VNE Fits: all 2021 S4 engines | 41000073 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Upper | View on Amazon |
| VNE Fits: all 2021 S4 engines | 41000074 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Lower | View on Amazon |
This table covers the Radiator insulators.
2 Radiator Insulator parts for the 2021 Audi S4 come from VNE. Every part fits both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged.
This group includes VNE 41000073 and VNE 41000074.
Radiator Insulator Sleeve
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: all 2021 S4 engines | AVM0730 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon |
This table covers the Radiator Insulator sleeves.
This group shows a single part: REIN AVM0730.
Radiator Mount
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: all 2021 S4 engines | AVM0729 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Center Upper | View on Amazon |
This table covers the Radiator mounts. Typical signs include a clunk on takeoff, a vibration at idle, or a separated rubber insert. Support the powertrain before unbolting a mount, and torque the fasteners in the notes.
This group shows a single part: REIN AVM0729.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: all 2021 S4 engines | 1814521 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Straight Connector | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BECK/ARNLEY Popular Fits: all 2021 S4 engines | 1581679 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | View on Amazon | |
| WALKER PRODUCTS Popular Fits: all 2021 S4 engines | 2112035 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Sensor Only | View on Amazon |
| NISSENS Fits: 3.0L V6 Turbocharged | 207067 | 🇺🇸 US | Oval Connector, bolted connection | View on Amazon |
| VNE Fits: 3.0L V6 Turbocharged | 9408050 | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
| WELLS Fits: all 2021 S4 engines | 5S16784 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Lower | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
6 Temperature Sender / Sensor parts are listed for the 2021 Audi S4, from GPD, BECK/ARNLEY, WALKER PRODUCTS and 3 other brands. BECK/ARNLEY 1581679 carries the "Popular" badge. 4 parts fit every engine; the other 2 are engine-specific.
Economy: 1 part, from GPD. A representative part number is GPD 1814521.
The Standard Replacement section: 5 options from BECK/ARNLEY, WALKER PRODUCTS, NISSENS and 2 other brands. BECK/ARNLEY 1581679 is listed in this group.
Part numbers include BECK/ARNLEY 1581679, GPD 1814521 and WALKER PRODUCTS 2112035, among others listed above.
Thermostat
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CALORSTAT Fits: all 2021 S4 engines | TE7367103J | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Includes 1 Rubber Gasket | View on Amazon |
| MOTORAD Fits: all 2021 S4 engines | 1229221 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Includes Sensor and SealStandard | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
2 Thermostat parts for the 2021 Audi S4 come from 2 brands — CALORSTAT and MOTORAD. Every part fits both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged.
This group includes CALORSTAT TE7367103J and MOTORAD 1229221.
Thermostat Housing / Water Outlet
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VEMO Fits: 3.0L V6 Turbocharged | V10990020 | 🇺🇸 US | Thermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
This group shows a single part: VEMO V10990020.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BECK/ARNLEY Popular Fits: 3.0L V6 Turbocharged | 1312513 | 🇺🇸 US 🇨🇦 CA | Auxiliary | View on Amazon |
| VAICO Popular Fits: all 2021 S4 engines | V1050112 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | From 08/31/2017 | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular Fits: all 2021 S4 engines | 41568E | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Electric | View on Amazon |
| FOUR SEASONS Fits: all 2021 S4 engines | 89087 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | AuxiliaryHeater Water Pump | View on Amazon |
| FOUR SEASONS Fits: all 2021 S4 engines | 89084 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Auxiliary | View on Amazon |
| NISSENS Fits: 3.0L V6 Turbocharged | 832121 | 🇺🇸 US | Auxiliary | View on Amazon |
| PIERBURG Fits: all 2021 S4 engines | 708002060 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Electric | View on Amazon |
| PIERBURG Fits: all 2021 S4 engines | 708002030 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Electric | View on Amazon |
| PIERBURG Fits: all 2021 S4 engines | 704071650 | 🇺🇸 US 🇨🇦 CA 🇲🇽 MX | Electric | View on Amazon |
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| HELLA Fits: 3.0L V6 Turbocharged | 358304701 | 🇺🇸 US | Auxiliary | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
10 Water Pump parts for the 2021 Audi S4 come from 7 brands — PIERBURG, FOUR SEASONS, BECK/ARNLEY and 4 other brands. The "Popular" part is BECK/ARNLEY 1312513. 7 parts fit every engine; the other 3 are engine-specific.
The Economy section: 2 options from BECK/ARNLEY and VAICO. BECK/ARNLEY 1312513 is listed in this group.
Standard Replacement: 7 parts, from PIERBURG, FOUR SEASONS, GATES and 1 other brand. A representative part number is GATES 41568E.
1 further part sits outside the graded sections, with the same engine-level match.
Buying Cooling System Parts for a 2021 Audi S4
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Water Pump .
Frequently Asked Questions
How many cooling system parts fit the 2021 Audi S4?
Our catalog currently lists 54 cooling system parts for the 2021 Audi S4 across 15 subcategories and 26 brands, covering both the 3.0L V6 Supercharged and the 3.0L V6 Turbocharged. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 Audi S4 engines?
Some do. 42 parts fit every engine; the other 12 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 Audi S4?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Audi S4 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Audi S4?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Audi S4
Cooling System Parts for Other Audi S4 Years
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