The 2021 Chevrolet Cheyenne has 22 cooling system parts with verified fitment on this page — 7 part types and 10 brands, covering both the 5.3L V8 and the 6.2L V8. Each part includes a manufacturer part number and application notes.
The cooling system system on the 2021 Chevrolet Cheyenne keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (10 parts), Coolant Reservoir Cap (3 parts) and Thermostat (3 parts). The other 4 part types cover the remaining 6 parts.
The 2021 Chevrolet Cheyenne was sold with both the 5.3L V8 and the 6.2L V8. All 22 parts on this page fit every engine.
The most listed brands for 2021 Chevrolet Cheyenne cooling system parts are PRESTONE (5 parts), DORMAN (5 parts) and PEAK (3 parts), plus 7 more brands. Quality grades include Economy, Premium and Standard Replacement.
2 parts on this 2021 Chevrolet Cheyenne page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including PRESTONE AF3100 (Coolant / Antifreeze) and PRESTONE AF2100 (Coolant / Antifreeze). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 Cheyenne engines | AF3055 | 🇲🇽 MX | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 Cheyenne engines | AF3100 | 🇲🇽 MX | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| PEAK Fits: all 2021 Cheyenne engines | BQA1GAL | 🇲🇽 MX | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| VALVOLINE Fits: all 2021 Cheyenne engines | 719009 | 🇲🇽 MX | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 Cheyenne engines | AFC12100 | 🇲🇽 MX | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 Cheyenne engines | AF2100 | 🇲🇽 MX | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 Cheyenne engines | PKP1GAL | 🇲🇽 MX | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Cheyenne engines | PXA1GAL | 🇲🇽 MX | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 Cheyenne engines | AFMAX | 🇲🇽 MX | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AISIN Fits: all 2021 Cheyenne engines | ACD005 | 🇲🇽 MX | OrangeOAT | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
10 Coolant / Antifreeze parts for the 2021 Chevrolet Cheyenne come from 4 brands — PRESTONE, PEAK, VALVOLINE and 1 other brand. The "Popular" part is PRESTONE AF3100. Every part fits both the 5.3L V8 and the 6.2L V8.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 3 options from PRESTONE, PEAK and VALVOLINE — the catalog's value-priced group. PRESTONE AF3100 is listed in this group.
In the Heavy Duty grade, PRESTONE supplies 1 part: rated for severe service. A representative part number is PRESTONE AFC12100.
In the Premium grade, PRESTONE and PEAK supply 4 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, AISIN supplies 1 part: built to original-equipment specification. A representative part number is AISIN ACD005.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2021 Cheyenne engines | 603149 | 🇲🇽 MX | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
One part is listed for the 2021 Chevrolet Cheyenne — DORMAN 603149.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2021 Cheyenne engines | 54218 | 🇲🇽 MX | View on Amazon | |
| MOTORAD Fits: all 2021 Cheyenne engines | T62 | 🇲🇽 MX | Standard | View on Amazon |
| SKP Fits: all 2021 Cheyenne engines | SK54218 | 🇲🇽 MX | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
3 Coolant Reservoir Cap parts are listed for the 2021 Chevrolet Cheyenne, from DORMAN, MOTORAD and SKP. All of them fit every engine offered in the 2021 Cheyenne.
Listed part numbers: DORMAN 54218, MOTORAD T62 and SKP SK54218.
Radiator Fan Assembly
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2021 Cheyenne engines | 621806 | 🇲🇽 MX | without Regular Production Option Code NHT (Enhanced Towing Package) | View on Amazon |
This table covers the fan assemblies (and clutches, where listed) that pull air through the radiator.
One part is listed for the 2021 Chevrolet Cheyenne — DORMAN 621806.
Temperature Sender / Sensor
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: all 2021 Cheyenne engines | 1712496 | 🇲🇽 MX | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
This group shows a single part: GPD 1712496.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AUTOTECNICA Fits: all 2021 Cheyenne engines | GM0718523 | 🇲🇽 MX | Includes Housing | View on Amazon |
| DORMAN Fits: all 2021 Cheyenne engines | 9022981 | 🇲🇽 MX | Includes Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: all 2021 Cheyenne engines | 523190 | 🇲🇽 MX | Includes Seal | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
3 Thermostat parts are listed for the 2021 Chevrolet Cheyenne, from AUTOTECNICA, DORMAN and MOTORAD. All of them fit every engine offered in the 2021 Cheyenne.
Economy: 2 parts, from AUTOTECNICA and DORMAN. A representative part number is AUTOTECNICA GM0718523.
The Standard Replacement section: 1 option from MOTORAD. MOTORAD 523190 is listed in this group.
This group includes AUTOTECNICA GM0718523, DORMAN 9022981 and MOTORAD 523190.
Thermostat Housing / Water Outlet
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2021 Cheyenne engines | 9022081 | 🇲🇽 MX | Water PumpThermostat Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: all 2021 Cheyenne engines | 85945 | 🇲🇽 MX | Water Outlet | View on Amazon |
| MOTORAD Fits: all 2021 Cheyenne engines | CH5945 | 🇲🇽 MX | Water Outlet | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
3 Thermostat Housing / Water Outlet parts are listed for the 2021 Chevrolet Cheyenne, from DORMAN, FOUR SEASONS and MOTORAD. All of them fit every engine offered in the 2021 Cheyenne.
Economy: 1 part, from DORMAN. A representative part number is DORMAN 9022081.
The Standard Replacement section: 2 options from FOUR SEASONS and MOTORAD. FOUR SEASONS 85945 is listed in this group.
Listed part numbers: DORMAN 9022081, FOUR SEASONS 85945 and MOTORAD CH5945.
Buying Cooling System Parts for a 2021 Chevrolet Cheyenne
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- You do not need to pick an engine: every cooling system part on this page fits both the 5.3L V8 and the 6.2L V8.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Coolant Reservoir Cap .
Frequently Asked Questions
How many cooling system parts fit the 2021 Chevrolet Cheyenne?
Our catalog currently lists 22 cooling system parts for the 2021 Chevrolet Cheyenne across 7 subcategories and 10 brands, covering both the 5.3L V8 and the 6.2L V8. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 Chevrolet Cheyenne engines?
No. On this page every cooling system part fits both the 5.3L V8 and the 6.2L V8. You do not need to pick an engine to choose the right row — use the notes for position and trim.
What are the signs of cooling system problems on a 2021 Chevrolet Cheyenne?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Chevrolet Cheyenne was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Chevrolet Cheyenne?
Every part on this page already fits both the 5.3L V8 and the 6.2L V8. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Chevrolet Cheyenne
Cooling System Parts for Other Chevrolet Cheyenne Years
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