2021 Chevrolet Express 3500 Cooling System Parts

Engine:

Showing parts for every engine. Select an engine to see only what fits.

The 2021 Chevrolet Express 3500 has 118 cooling system parts with verified fitment on this page — 24 part types and 31 brands, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Each part includes a manufacturer part number and application notes.

On the 2021 Chevrolet Express 3500, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. 43 parts of the 118 listed are Thermostat (18 parts), Coolant / Antifreeze (17 parts) and Radiator (8 parts). The other 21 part types cover the remaining 75 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE Fits: 4.3L V6, 6.6L V8 AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
View on
Amazon

Economy

Brand Part Number Markets Notes Buy
FVP Popular Fits: 4.3L V6, 6.6L V8 MV5050GAL
🇺🇸 US 🇨🇦 CA
Extended LifeAll Makes / All Models
Fitment notes — FVP MV5050GAL
Extended LifeAll Makes / All Models1 Gallon
View on
Amazon
PEAK Fits: 4.3L V6, 6.6L V8 BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
View on
Amazon
PRESTONE Fits: 4.3L V6, 6.6L V8 AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
View on
Amazon
VALVOLINE Fits: 4.3L V6, 6.6L V8 719009
🇺🇸 US 🇨🇦 CA
Multi-Vehicle Yellow1 Gallon
Fitment notes — VALVOLINE 719009
Multi-Vehicle Yellow1 Gallon
Gas
View on
Amazon

Heavy Duty

Brand Part Number Markets Notes Buy
PRESTONE Fits: 4.3L V6, 6.6L V8 AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
View on
Amazon

Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular Fits: 4.3L V6, 6.6L V8 AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
View on
Amazon
PEAK Fits: 4.3L V6, 6.6L V8 PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
View on
Amazon
PEAK Fits: 4.3L V6, 6.6L V8 PXA1GAL
🇺🇸 US 🇨🇦 CA
Global Lifetime1 Gallon
View on
Amazon
PRESTONE Fits: 4.3L V6, 6.6L V8 AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular Fits: 4.3L V6, 6.6L V8 105027
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon
Fitment notes — ACDELCO 105027
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 GallonPremix1 Gallon GM Original EquipmentOrange
View on
Amazon
VALVOLINE Popular Fits: 4.3L V6, 6.6L V8 ZXEL1
🇺🇸 US 🇨🇦 CA
Dex-Cool Orange1 Gallon
Fitment notes — VALVOLINE ZXEL1
Dex-Cool Orange1 GallonOAT
Gas
View on
Amazon
AISIN Fits: 4.3L V6, 6.6L V8 ACD005
🇺🇸 US 🇨🇦 CA
OrangeOAT
Fitment notes — AISIN ACD005
OrangeOAT
(Type: Prediluted)
View on
Amazon
FVP Fits: 4.3L V6, 6.6L V8 DEX5050GAL
🇺🇸 US 🇨🇦 CA
Extended Life Blend1 Gallon
Fitment notes — FVP DEX5050GAL
Extended Life Blend1 GallonOrangeOAT
View on
Amazon
PRESTONE Fits: 4.3L V6, 6.6L V8 AF3400
🇺🇸 US 🇨🇦 CA
Prime OrangeOrange Compatible
Fitment notes — PRESTONE AF3400
Prime OrangeOrange CompatibleExtended Life1 Gallon ConcentrateOAT
View on
Amazon
PRESTONE Fits: 4.3L V6, 6.6L V8 AF850
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended Life1 Gallon
Fitment notes — PRESTONE AF850
DEX-Cool Extended Life1 GallonOrangeOAT
View on
Amazon
VALVOLINE Fits: 4.3L V6, 6.6L V8 888374
🇺🇸 US 🇨🇦 CA
American Vehicle Orange1 Gallon
Fitment notes — VALVOLINE 888374
American Vehicle Orange1 Gallon
Gas (Type: Prediluted)
(Type: Prediluted)
View on
Amazon

This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Hose / Pipe

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 25866165
🇺🇸 US 🇨🇦 CA
InletOn Reservoir
View on
Amazon
GM GENUINE Fits: 4.3L V6 84443244
🇺🇸 US 🇨🇦 CA
Expansion Tank To Radiator135.0" Wheelbase or 139.0" Wheelbase or 155.0" Wheelbase
View on
Amazon
GM GENUINE Fits: 6.6L V8 84882346
🇺🇸 US 🇨🇦 CA
Expansion tank to radiator
View on
Amazon

This table covers the hard pipes and extra hoses in the coolant circuit.

Coolant Hose Connector / Flange

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 1510595
🇺🇸 US 🇨🇦 CA
8 speed Automatic trans.
Fitment notes — GM GENUINE 1510595
8 speed Automatic trans.
6 speed Automatic trans.
View on
Amazon

This table covers the Coolant Hose Connector flanges.

Coolant Hose Retainer / Clip

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6 11547445
🇺🇸 US 🇨🇦 CA
135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseOmega Clip
Fitment notes — GM GENUINE 11547445
135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseOmega Clip35MM Maximum Inside Diameter
View on
Amazon
GM GENUINE Fits: 6.6L V8 11547271
🇺🇸 US 🇨🇦 CA
InletTie Strap with Clip
Fitment notes — GM GENUINE 11547271
InletTie Strap with ClipHeater VentFits 10-14MM Tube
View on
Amazon

This table covers the Coolant Hose retainers and clips.

Coolant Reservoir

Brand Part Number Markets Notes Buy
DORMAN Fits: 4.3L V6, 6.6L V8 603078
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 85604316
🇺🇸 US 🇨🇦 CA
Reservoir Material: Polypropylene (PP)
Fitment notes — GM GENUINE 85604316
Reservoir Material: Polypropylene (PP)
Exc. Coolant Cap with Tether(9C7)
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 85666315
🇺🇸 US 🇨🇦 CA
Reservoir Material: Polypropylene (PP)
Fitment notes — GM GENUINE 85666315
Reservoir Material: Polypropylene (PP)
Coolant Cap with Tether (9C7)
View on
Amazon
GPD Fits: 4.3L V6, 6.6L V8 2411182
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the overflow / expansion tanks that hold extra coolant.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
DORMAN Popular Fits: 6.6L V8 54218
🇺🇸 US 🇨🇦 CA
View on
Amazon
SKP Popular Fits: 6.6L V8 SK54218
🇺🇸 US 🇨🇦 CA
View on
Amazon
CALORSTAT Fits: 4.3L V6, 6.6L V8 RC0147
🇺🇸 US 🇨🇦 CA
Maximum Pressure Rating: 15.0 PS
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 RC121
🇺🇸 US 🇨🇦 CA
Pressure Release Lever: No
Fitment notes — GM GENUINE RC121
Pressure Release Lever: No
Cutaway VanCoolant Cap with Tether(9C7)
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 RC122
🇺🇸 US 🇨🇦 CA
Exc. Coolant Cap with Tether(9C7)
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 T80
🇺🇸 US 🇨🇦 CA
Standard
View on
Amazon

This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Coolant Reservoir Retainer / Clip

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 10121502
🇺🇸 US 🇨🇦 CA
Cutaway VanHead OD=17.8, Length
Fitment notes — GM GENUINE 10121502
Cutaway VanHead OD=17.8, Lengthfor 6.25mm Hole5.8mm O.D. X 26.9MM LongCoolant Cap with Tether(9C7)
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 23382103
🇺🇸 US 🇨🇦 CA
Cutaway VanCoolant Cap with Tether(9C7)
View on
Amazon

This table covers the Coolant Reservoir retainers and clips.

Hose Clamp

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6 11548759
🇺🇸 US 🇨🇦 CA
RESERVOIR HOSE
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 90530642
🇺🇸 US 🇨🇦 CA
135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseClamp-Sprindband, 14X12, Double Band
Fitment notes — GM GENUINE 90530642
135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseClamp-Sprindband, 14X12, Double BandReservoir Hose
Fits:
Clamp-Sprindband, 14X12, Double BandAir Bleed Hos
or:
Clamp-Sprindband, 14X12, Double BandReservoir Hose
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 86308358
🇺🇸 US 🇨🇦 CA
Coolant Cap with Tether(9C7)Reservoir Hose
View on
Amazon
GM GENUINE Fits: 6.6L V8 11603888
🇺🇸 US 🇨🇦 CA
Adjustment Type: YES
Fitment notes — GM GENUINE 11603888
Adjustment Type: YES
LowerRadiator Hose
View on
Amazon

This table covers the Hose clamps.

Intercooler Seal

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 19130019
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the seals at the Intercooler. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Radiator

Economy

Brand Part Number Markets Notes Buy
GPD Fits: 4.3L V6 2791C
🇺🇸 US 🇨🇦 CA
without Sensor Port
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
GM GENUINE Popular Fits: 4.3L V6 21939
🇺🇸 US 🇨🇦 CA
View on
Amazon
CSF Fits: 4.3L V6 4023
🇺🇸 US 🇨🇦 CA
11% Thicker Core 30mm vs OEM 27mm. with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings
View on
Amazon
SPECTRA PREMIUM Fits: 4.3L V6 CU13867
🇺🇸 US 🇨🇦 CA
View on
Amazon
UAC Fits: 4.3L V6 RA13867C
🇺🇸 US 🇨🇦 CA
View on
Amazon
Brand Part Number Markets Notes Buy
CSF Fits: 6.6L V8 4021
🇺🇸 US 🇨🇦 CA
with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings.
View on
Amazon
FVP Fits: 6.6L V8 RAD14058
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE Fits: 6.6L V8 84916454
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Brand Part Number Markets Notes Buy
ACDELCO Fits: 4.3L V6, 6.6L V8 RC85
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO RC85
GM Original Equipment
15 PSI
View on
Amazon
GATES Fits: 4.3L V6, 6.6L V8 31532
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 31532
OE Type
15 psi Pressure Rating
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 T46
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T46
Standard
Relief Pressure 15 lbs
View on
Amazon

This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Drain Petcock

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 22790134
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the petcocks used to drain the radiator.

Radiator Fan Blade

Brand Part Number Markets Notes Buy
ACDELCO Fits: 4.3L V6 1581941
🇺🇸 US 🇨🇦 CA
GM Original Equipment
View on
Amazon
ACDELCO Fits: 6.6L V8 84723175
🇺🇸 US 🇨🇦 CA
GM Original Equipment
View on
Amazon
GM GENUINE Fits: 4.3L V6 86532392
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE Fits: 6.6L V8 86532393
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
FOUR SEASONS Fits: 4.3L V6 46144
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — FOUR SEASONS 46144
Severe Duty Thermal
Counter Clockwise
View on
Amazon
FOUR SEASONS Fits: 6.6L V8 46145
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — FOUR SEASONS 46145
Severe Duty Thermal
Counter Clockwise
View on
Amazon
GM GENUINE Fits: 4.3L V6 1540585
🇺🇸 US 🇨🇦 CA
Thermal
View on
Amazon
GM GENUINE Fits: 6.6L V8 84595910
🇺🇸 US 🇨🇦 CA
Thermal
View on
Amazon
HAYDEN Fits: 4.3L V6 2983
🇺🇸 US 🇨🇦 CA
ThermalSevere Duty
Fitment notes — HAYDEN 2983
ThermalSevere Duty
Counter Clockwise
View on
Amazon
HAYDEN Fits: 6.6L V8 2984
🇺🇸 US 🇨🇦 CA
ThermalSevere Duty
Fitment notes — HAYDEN 2984
ThermalSevere Duty
Counter Clockwise
View on
Amazon
US MOTOR WORKS Fits: 4.3L V6 22169
🇺🇸 US 🇨🇦 CA
Thermal
View on
Amazon

This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Fan Motor Bracket

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 24591472
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.

Radiator Fan Shroud

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6 84362765
🇺🇸 US 🇨🇦 CA
Rearward
View on
Amazon
GM GENUINE Fits: 6.6L V8 84145362
🇺🇸 US 🇨🇦 CA
Rearward
View on
Amazon

This table covers the shrouds that duct air through the fan and radiator.

Radiator Hose

Brand Part Number Markets Notes Buy
ACDELCO Fits: 4.3L V6 84186464
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 84186464
GM Original Equipment
Fits:
UpperCutaway Van139.0" Wheelbase
or:
UpperStandard Cargo Van or Standard Passenger Van3 door135.0" Wheelbase
or:
UpperExtended Cargo Van or Extended Passenger Van155.0" Wheelbase
View on
Amazon
ACDELCO Fits: 6.6L V8 85144276
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 85144276
GM Original Equipment
Upperwithout CLAMP
View on
Amazon
ACDELCO Fits: 6.6L V8 84882345
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 84882345
GM Original Equipment
Lowerwithout CLAMP
View on
Amazon
ACDELCO Fits: 6.6L V8 84984107
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 84984107
GM Original Equipment
Lowerwith Clamp
View on
Amazon

This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
ULTRA-POWER Popular Fits: 4.3L V6, 6.6L V8 5S13427
🇺🇸 US 🇨🇦 CA
View on
Amazon
GPD Fits: 4.3L V6, 6.6L V8 1712496
🇺🇸 US 🇨🇦 CA
View on
Amazon
HOLSTEIN Fits: 4.3L V6, 6.6L V8 2CTS0184
🇺🇸 US 🇨🇦 CA
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
STANDARD MOTOR PRODUCTS Popular Fits: 4.3L V6, 6.6L V8 TX247
🇺🇸 US 🇨🇦 CA
View on
Amazon
FACET Fits: 4.3L V6, 6.6L V8 73379
🇺🇸 US 🇨🇦 CA
Connector Shape: Oblong
Fitment notes — FACET 73379
Connector Shape: Oblong
Flex Fuel
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 25186240
🇺🇸 US 🇨🇦 CA
8 speed Automatic trans.THREADS IN BLOCK
Fitment notes — GM GENUINE 25186240
8 speed Automatic trans.THREADS IN BLOCKMating Connector Use 13587326
6 speed Automatic trans.THREADS IN BLOCKMating Connector Use 13587326
View on
Amazon
WALKER PRODUCTS Fits: 4.3L V6, 6.6L V8 2112015
🇺🇸 US 🇨🇦 CA
SensorIncludes O-Ring
View on
Amazon
WELLS Fits: 4.3L V6, 6.6L V8 5S13427
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
AUTOTECNICA Fits: 4.3L V6, 6.6L V8 GM0718523
🇺🇸 US 🇨🇦 CA
Includes Housing
Fitment notes — AUTOTECNICA GM0718523
Includes Housing
Sealing Flange Outside Diameter: 72mm
View on
Amazon
DORMAN Fits: 4.3L V6, 6.6L V8 9022981
🇺🇸 US 🇨🇦 CA
Includes Housing
Fitment notes — DORMAN 9022981
Includes Housing
Water Pump
View on
Amazon
SKP Fits: 4.3L V6, 6.6L V8 SK131160
🇺🇸 US 🇨🇦 CA
190 Degree
View on
Amazon

Heavy Duty

Brand Part Number Markets Notes Buy
MOTORAD Fits: 4.3L V6, 6.6L V8 5523187
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523187
Ultra StatIncludes seal
187 Degrees FOE Specified Temperature
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 5523160
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523160
Ultra StatIncludes seal
160 Degrees FAlternate Temperature Option
View on
Amazon

Performance

Brand Part Number Markets Notes Buy
MOTORAD Fits: 4.3L V6, 6.6L V8 2523160
🇺🇸 US 🇨🇦 CA
High FlowIncludes seal
Fitment notes — MOTORAD 2523160
High FlowIncludes seal
160 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 MRD105
🇺🇸 US 🇨🇦 CA
RacingIncludes Thermostat and Seal
Fitment notes — MOTORAD MRD105
RacingIncludes Thermostat and Seal
Temperature 160F
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular Fits: 4.3L V6, 6.6L V8 131160
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 131160
GM Original Equipment
8 speed Automatic trans.86 DEG C Thermostat. For 91 DEG C Thermostat See PN 19420815.
6 speed Automatic trans.86 DEG C Thermostat. For 91 DEG C Thermostat See PN 19420815.
View on
Amazon
GATES Popular Fits: 4.3L V6, 6.6L V8 34198
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 34198
OE Type
187 DegreeOE TemperatureSeal Included
View on
Amazon
MOTORAD Popular Fits: 4.3L V6, 6.6L V8 523190
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523190
Includes Seal
187 Degrees FOE Specified Temperature
View on
Amazon
MOTORAD Popular Fits: 4.3L V6, 6.6L V8 523160
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523160
Includes Seal
160 Degrees FAlternate Temperature Option
View on
Amazon
AISIN Fits: 4.3L V6 THRGM0002
🇺🇸 US 🇨🇦 CA
Includes Thermostat SealWithout Integrated Housing
Fitment notes — AISIN THRGM0002
Includes Thermostat SealWithout Integrated Housing
86°
View on
Amazon
CALORSTAT Fits: 4.3L V6 TH210786J
🇺🇸 US 🇨🇦 CA
Includes 1 Rubber Gasket
Fitment notes — CALORSTAT TH210786J
Includes 1 Rubber Gasket
187.0 F Degreeswith Larger Main Valve
View on
Amazon
CALORSTAT Fits: 4.3L V6 TH210782J
🇺🇸 US 🇨🇦 CA
PerformanceIncludes 1 Rubber Gasket
Fitment notes — CALORSTAT TH210782J
PerformanceIncludes 1 Rubber Gasket
180.0 Degreeswith Larger Main Valve
View on
Amazon
MAHLE / CLEVITE Fits: 4.3L V6, 6.6L V8 TX49971D
🇺🇸 US 🇨🇦 CA
Opening Temperature 71with Seal
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 523174
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523174
Includes Seal
174 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 523180
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523180
Includes Seal
180 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD Fits: 4.3L V6 5945KT
🇺🇸 US 🇨🇦 CA
Includes Thermostat and HousingKit
Fitment notes — MOTORAD 5945KT
Includes Thermostat and HousingKit
190 Degrees FOE Specified Temperature
View on
Amazon

This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
FEL-PRO Popular Fits: 4.3L V6 36106
🇺🇸 US 🇨🇦 CA
Thermostat Housing Seal
View on
Amazon
FEL-PRO Fits: 4.3L V6, 6.6L V8 36219
🇺🇸 US 🇨🇦 CA
Thermostat Seal
View on
Amazon
MAHLE / CLEVITE Fits: 4.3L V6 C32061
🇺🇸 US 🇨🇦 CA
Molded Rubber
Fitment notes — MAHLE / CLEVITE C32061
Molded Rubber
O-Ring TypeThermostat Seal
View on
Amazon
MAHLE / CLEVITE Fits: 4.3L V6 C32719
🇺🇸 US 🇨🇦 CA
Molded Rubber
Fitment notes — MAHLE / CLEVITE C32719
Molded Rubber
Thermostat Seal
View on
Amazon
VICTOR REINZ Fits: 4.3L V6, 6.6L V8 711357800
🇺🇸 US 🇨🇦 CA
Thermostat Seal
View on
Amazon

This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Thermostat Housing / Water Outlet

Economy

Brand Part Number Markets Notes Buy
DORMAN Fits: 4.3L V6, 6.6L V8 9022081
🇺🇸 US 🇨🇦 CA
Water PumpThermostat Housing
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
FOUR SEASONS Fits: 4.3L V6, 6.6L V8 85945
🇺🇸 US 🇨🇦 CA
Water Outlet
View on
Amazon
MOTORAD Fits: 4.3L V6, 6.6L V8 CH5945
🇺🇸 US 🇨🇦 CA
Water Outlet
View on
Amazon

This table covers the housings and outlets the thermostat sits in.

Water Inlet Gasket

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 4.3L V6, 6.6L V8 12587397
🇺🇸 US 🇨🇦 CA
8 speed Automatic trans.
Fitment notes — GM GENUINE 12587397
8 speed Automatic trans.
6 speed Automatic trans.
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 12650512
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump

Economy

Brand Part Number Markets Notes Buy
WJB / INMOTION PARTS Fits: 4.3L V6 WU1303160
🇺🇸 US 🇨🇦 CA
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
GATES Popular Fits: 4.3L V6 45073
🇺🇸 US 🇨🇦 CA
Includes Thermostat
View on
Amazon
FVP Fits: 4.3L V6 1303160
🇺🇸 US 🇨🇦 CA
Water Pump Drive Type: Serpentine Belt
View on
Amazon
GM GENUINE Fits: 4.3L V6 12740339
🇺🇸 US 🇨🇦 CA
8 speed Automatic trans.
View on
Amazon
GMB Fits: 4.3L V6 1303160
🇺🇸 US 🇨🇦 CA
View on
Amazon
Brand Part Number Markets Notes Buy
FVP Fits: 6.6L V8 1303210
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE Fits: 6.6L V8 12735409
🇺🇸 US 🇨🇦 CA
Includes Thermostat
Fitment notes — GM GENUINE 12735409
Includes Thermostat
6 speed Automatic trans.
View on
Amazon
GMB Fits: 6.6L V8 1303210
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Water Pump Gasket

Brand Part Number Markets Notes Buy
FEL-PRO Fits: 4.3L V6, 6.6L V8 36110
🇺🇸 US 🇨🇦 CA
To BlockHousing To Block
View on
Amazon
FEL-PRO Fits: 4.3L V6, 6.6L V8 36109
🇺🇸 US 🇨🇦 CA
To BlockPump To Housing
View on
Amazon
GM GENUINE Fits: 4.3L V6, 6.6L V8 2512073
🇺🇸 US 🇨🇦 CA
8 speed Automatic trans.
View on
Amazon
MAHLE / CLEVITE Fits: 6.6L V8 K33358
🇺🇸 US 🇨🇦 CA
SteelIncludes 2 Gaskets
Fitment notes — MAHLE / CLEVITE K33358
SteelIncludes 2 Gaskets
PUMP TO HOUSING
View on
Amazon

This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Buying Cooling System Parts for a 2021 Chevrolet Express 3500

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Match the engine first. Every cooling system part here is engine-specific; each row shows which engine(s) it fits.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Thermostat and Coolant / Antifreeze .

Frequently Asked Questions

How many cooling system parts fit the 2021 Chevrolet Express 3500?

Our catalog currently lists 118 cooling system parts for the 2021 Chevrolet Express 3500 across 24 subcategories and 31 brands, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Each part is matched to the engine(s) it fits.

Do cooling system parts differ between 2021 Chevrolet Express 3500 engines?

Yes. Every cooling system part on this page is engine-specific. Each row shows which engine(s) it fits — use the filter at the top to hide the rest. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.

What are the signs of cooling system problems on a 2021 Chevrolet Express 3500?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Chevrolet Express 3500 was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2021 Chevrolet Express 3500?

First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2021 Chevrolet Express 3500

Cooling System Parts for Other Chevrolet Express 3500 Years

Switch vehicle or jump to a subcategory

Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.