2021 Chevrolet Express 4500 Cooling System Parts

Engine:
6.6L V8

This page lists 81 cooling system parts for the 2021 Chevrolet Express 4500, across 24 part types, covering the 6.6L V8 engine. Every part shows its brand, manufacturer part number and fitment notes.

The cooling system system on the 2021 Chevrolet Express 4500 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (15 parts), Thermostat (12 parts) and Coolant Reservoir Cap (5 parts). The other 21 part types cover the remaining 49 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
View on
Amazon

Economy

Brand Part Number Markets Notes Buy
PEAK BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
View on
Amazon
PRESTONE AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
View on
Amazon

Heavy Duty

Brand Part Number Markets Notes Buy
PEAK FCA1GAL
🇺🇸 US 🇨🇦 CA
Fleet Charge1 Gallon
Fitment notes — PEAK FCA1GAL
Fleet Charge1 GallonFLEET CHARGE 1 GALLON
View on
Amazon
PEAK FXA1GAL
🇺🇸 US 🇨🇦 CA
Final Charge Global1 Gallon
Fitment notes — PEAK FXA1GAL
Final Charge Global1 GallonFINAL CHARGENITRITE FREEGLOBAL EXTENDED LIFE 1 GALLON
View on
Amazon
PRESTONE AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
View on
Amazon

Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
View on
Amazon
PEAK PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
View on
Amazon
PEAK PXA1GAL
🇺🇸 US 🇨🇦 CA
Global Lifetime1 Gallon
View on
Amazon
PRESTONE AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular 105027
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon
Fitment notes — ACDELCO 105027
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 GallonPremix1 Gallon GM Original EquipmentOrange
View on
Amazon
PRESTONE Popular AF3400
🇺🇸 US 🇨🇦 CA
Prime OrangeOrange Compatible
Fitment notes — PRESTONE AF3400
Prime OrangeOrange CompatibleExtended Life1 Gallon ConcentrateOAT
View on
Amazon
AISIN ACD005
🇺🇸 US 🇨🇦 CA
OrangeOAT
Fitment notes — AISIN ACD005
OrangeOAT
(Type: Prediluted)
View on
Amazon
PEAK PDC1GAL
🇺🇸 US 🇨🇦 CA
GM DEX-Cool1 Gallon
Fitment notes — PEAK PDC1GAL
GM DEX-Cool1 GallonGM APPROVED DEX-COOL 1 GALLON
View on
Amazon
PRESTONE AF850
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended Life1 Gallon
Fitment notes — PRESTONE AF850
DEX-Cool Extended Life1 GallonOrangeOAT
View on
Amazon

This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Hose / Pipe

Brand Part Number Markets Notes Buy
GM GENUINE 25866165
🇺🇸 US 🇨🇦 CA
InletOn Reservoir
View on
Amazon
GM GENUINE 84882346
🇺🇸 US 🇨🇦 CA
Expansion tank to radiator
View on
Amazon

This table covers the hard pipes and extra hoses in the coolant circuit.

Coolant Hose Connector / Flange

Brand Part Number Markets Notes Buy
GM GENUINE 1510595
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the Coolant Hose Connector flanges.

Coolant Hose Retainer / Clip

Brand Part Number Markets Notes Buy
GM GENUINE 11547271
🇺🇸 US 🇨🇦 CA
InletTie Strap with Clip
Fitment notes — GM GENUINE 11547271
InletTie Strap with ClipHeater VentFits 10-14MM Tube
View on
Amazon

This table covers the Coolant Hose retainers and clips.

Coolant Reservoir

Brand Part Number Markets Notes Buy
DORMAN 603078
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE 85604316
🇺🇸 US 🇨🇦 CA
Reservoir Material: Polypropylene (PP)
Fitment notes — GM GENUINE 85604316
Reservoir Material: Polypropylene (PP)
Exc. Coolant Cap with Tether(9C7)
View on
Amazon
GM GENUINE 85666315
🇺🇸 US 🇨🇦 CA
Reservoir Material: Polypropylene (PP)
Fitment notes — GM GENUINE 85666315
Reservoir Material: Polypropylene (PP)
Coolant Cap with Tether (9C7)
View on
Amazon
GPD 2411182
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the overflow / expansion tanks that hold extra coolant.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
DORMAN Popular 54218
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE RC121
🇺🇸 US 🇨🇦 CA
Pressure Release Lever: No
Fitment notes — GM GENUINE RC121
Pressure Release Lever: No
Coolant Cap with Tether (9C7)
View on
Amazon
GM GENUINE RC122
🇺🇸 US 🇨🇦 CA
Exc. Coolant Cap with Tether(9C7)
View on
Amazon
MOTORAD T80
🇺🇸 US 🇨🇦 CA
Standard
View on
Amazon
SKP SK54218
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Coolant Reservoir Retainer / Clip

Brand Part Number Markets Notes Buy
GM GENUINE 10121502
🇺🇸 US 🇨🇦 CA
Head OD=17.8, Lengthfor 6.25mm Hole
Fitment notes — GM GENUINE 10121502
Head OD=17.8, Lengthfor 6.25mm Hole5.8mm O.D. X 26.9MM LongCoolant Cap with Tether(9C7)
View on
Amazon
GM GENUINE 23382103
🇺🇸 US 🇨🇦 CA
Coolant Cap with Tether (9C7)
View on
Amazon

This table covers the Coolant Reservoir retainers and clips.

Hose Clamp

Brand Part Number Markets Notes Buy
GM GENUINE 90530642
🇺🇸 US 🇨🇦 CA
Fits Clamp-Sprindband, 14X12, Double BandAir Bleed Hos
Fitment notes — GM GENUINE 90530642
Fits:
Clamp-Sprindband, 14X12, Double BandAir Bleed Hos
or:
Clamp-Sprindband, 14X12, Double BandReservoir Hose
View on
Amazon
GM GENUINE 11603888
🇺🇸 US 🇨🇦 CA
Adjustment Type: YES
Fitment notes — GM GENUINE 11603888
Adjustment Type: YES
LowerRadiator Hose
View on
Amazon
GM GENUINE 86308358
🇺🇸 US 🇨🇦 CA
Coolant Cap with Tether(9C7)Reservoir Hose
View on
Amazon

This table covers the Hose clamps.

Intercooler Seal

Brand Part Number Markets Notes Buy
GM GENUINE 19130019
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the seals at the Intercooler. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Radiator

Brand Part Number Markets Notes Buy
CSF 4021
🇺🇸 US 🇨🇦 CA
with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings.
View on
Amazon
FVP RAD14058
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE 84916454
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Brand Part Number Markets Notes Buy
ACDELCO RC85
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO RC85
GM Original Equipment
15 PSI
View on
Amazon
GATES 31532
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 31532
OE Type
15 psi Pressure Rating
View on
Amazon
MOTORAD T46
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T46
Standard
Relief Pressure 15 lbs
View on
Amazon

This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Drain Petcock

Brand Part Number Markets Notes Buy
GM GENUINE 22790134
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the petcocks used to drain the radiator.

Radiator Fan Blade

Brand Part Number Markets Notes Buy
ACDELCO 84723175
🇺🇸 US 🇨🇦 CA
GM Original Equipment
View on
Amazon
GM GENUINE 86532393
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
FOUR SEASONS 46145
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — FOUR SEASONS 46145
Severe Duty Thermal
Counter Clockwise
View on
Amazon
GM GENUINE 84595910
🇺🇸 US 🇨🇦 CA
Thermal
View on
Amazon
HAYDEN 2984
🇺🇸 US 🇨🇦 CA
ThermalSevere Duty
Fitment notes — HAYDEN 2984
ThermalSevere Duty
Counter Clockwise
View on
Amazon

This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Fan Motor Bracket

Brand Part Number Markets Notes Buy
GM GENUINE 24591472
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.

Radiator Fan Shroud

Brand Part Number Markets Notes Buy
GM GENUINE 84145362
🇺🇸 US 🇨🇦 CA
Rearward
View on
Amazon

This table covers the shrouds that duct air through the fan and radiator.

Radiator Hose

Brand Part Number Markets Notes Buy
ACDELCO 85144276
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 85144276
GM Original Equipment
Upperwithout CLAMP
View on
Amazon
ACDELCO 84882345
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 84882345
GM Original Equipment
Lowerwithout CLAMP
View on
Amazon
ACDELCO 84984107
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 84984107
GM Original Equipment
Lowerwith Clamp
View on
Amazon

This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
ULTRA-POWER Popular 5S13427
🇺🇸 US 🇨🇦 CA
View on
Amazon
GPD 1712496
🇺🇸 US 🇨🇦 CA
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
GM GENUINE 25186240
🇺🇸 US 🇨🇦 CA
Threads In Block
View on
Amazon
WALKER PRODUCTS 2112015
🇺🇸 US 🇨🇦 CA
SensorIncludes O-Ring
View on
Amazon
WELLS 5S13427
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
DORMAN 9022981
🇺🇸 US 🇨🇦 CA
Includes Housing
Fitment notes — DORMAN 9022981
Includes Housing
Water Pump
View on
Amazon
SKP SK131160
🇺🇸 US 🇨🇦 CA
190 Degree
View on
Amazon

Heavy Duty

Brand Part Number Markets Notes Buy
MOTORAD 5523187
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523187
Ultra StatIncludes seal
187 Degrees FOE Specified Temperature
View on
Amazon
MOTORAD 5523160
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523160
Ultra StatIncludes seal
160 Degrees FAlternate Temperature Option
View on
Amazon

Performance

Brand Part Number Markets Notes Buy
MOTORAD 2523160
🇺🇸 US 🇨🇦 CA
High FlowIncludes seal
Fitment notes — MOTORAD 2523160
High FlowIncludes seal
160 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD MRD105
🇺🇸 US 🇨🇦 CA
RacingIncludes Thermostat and Seal
Fitment notes — MOTORAD MRD105
RacingIncludes Thermostat and Seal
Temperature 160F
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular 131160
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 131160
GM Original Equipment
86 DEG C Thermostat. For 91 DEG C Thermostat See PN 19420815.
View on
Amazon
GATES Popular 34198
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 34198
OE Type
187 DegreeOE TemperatureSeal Included
View on
Amazon
MOTORAD Popular 523160
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523160
Includes Seal
160 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD 523190
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523190
Includes Seal
187 Degrees FOE Specified Temperature
View on
Amazon
MOTORAD 523174
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523174
Includes Seal
174 Degrees FAlternate Temperature Option
View on
Amazon
MOTORAD 523180
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523180
Includes Seal
180 Degrees FAlternate Temperature Option
View on
Amazon

This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
FEL-PRO 36219
🇺🇸 US 🇨🇦 CA
Thermostat Seal
View on
Amazon
VICTOR REINZ 711357800
🇺🇸 US 🇨🇦 CA
Thermostat Seal
View on
Amazon

This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Thermostat Housing / Water Outlet

Economy

Brand Part Number Markets Notes Buy
DORMAN 9022081
🇺🇸 US 🇨🇦 CA
Water PumpThermostat Housing
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
FOUR SEASONS 85945
🇺🇸 US 🇨🇦 CA
Water Outlet
View on
Amazon
MOTORAD CH5945
🇺🇸 US 🇨🇦 CA
Water Outlet
View on
Amazon

This table covers the housings and outlets the thermostat sits in.

Water Inlet Gasket

Brand Part Number Markets Notes Buy
GM GENUINE 12587397
🇺🇸 US 🇨🇦 CA
SINGLE USE
View on
Amazon
GM GENUINE 12650512
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump

Brand Part Number Markets Notes Buy
FVP 1303210
🇺🇸 US 🇨🇦 CA
View on
Amazon
GM GENUINE 12735409
🇺🇸 US 🇨🇦 CA
Includes Thermostat
View on
Amazon
GMB 1303210
🇺🇸 US 🇨🇦 CA
View on
Amazon

This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Water Pump Gasket

Brand Part Number Markets Notes Buy
FEL-PRO 36110
🇺🇸 US 🇨🇦 CA
To BlockHousing To Block
View on
Amazon
GM GENUINE 2512073
🇺🇸 US 🇨🇦 CA
View on
Amazon
MAHLE / CLEVITE K33358
🇺🇸 US 🇨🇦 CA
SteelIncludes 2 Gaskets
Fitment notes — MAHLE / CLEVITE K33358
SteelIncludes 2 Gaskets
PUMP TO HOUSING
View on
Amazon

This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Buying Cooling System Parts for a 2021 Chevrolet Express 4500

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Confirm you have the 6.6L V8 engine — every part on this page is matched to it.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Coolant / Antifreeze and Thermostat .

Frequently Asked Questions

How many cooling system parts fit the 2021 Chevrolet Express 4500?

Our catalog currently lists 81 cooling system parts for the 2021 Chevrolet Express 4500 across 24 subcategories and 21 brands, covering the 6.6L V8 engine. Each part is matched to the engine(s) it fits.

What are the signs of cooling system problems on a 2021 Chevrolet Express 4500?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Chevrolet Express 4500 was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2021 Chevrolet Express 4500?

Every part on this page is matched to the 6.6L V8 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2021 Chevrolet Express 4500

Cooling System Parts for Other Chevrolet Express 4500 Years

Switch vehicle or jump to a subcategory

Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.