The 2021 Freightliner Sprinter 3500 has 25 cooling system parts with verified fitment on this page — 7 part types and 9 brands, covering both the 2.1L L4 DIESEL Turbocharged and the 3.0L V6 DIESEL Turbocharged. Each part includes a manufacturer part number and application notes.
On the 2021 Freightliner Sprinter 3500, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. Most of the listed parts are Coolant / Antifreeze (16 parts), Coolant Hose / Pipe (3 parts) and Intercooler (2 parts). The other 4 part types cover the remaining 4 parts.
The 2021 Freightliner Sprinter 3500 was sold with both the 2.1L L4 DIESEL Turbocharged and the 3.0L V6 DIESEL Turbocharged. 18 parts fit every engine; the other 7 are engine-specific. Each part shows which engine(s) it fits.
9 brands supply cooling system parts for the 2021 Freightliner Sprinter 3500, led by PRESTONE (5 parts), PEAK (5 parts) and REIN (5 parts), plus 6 more brands. Quality grades include Standard Replacement, Premium and Economy.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 Freightliner Sprinter 3500. 4 parts have it, including PRESTONE AF3100 (Coolant / Antifreeze) and VALVOLINE 719009 (Coolant / Antifreeze). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 Sprinter 3500 engines | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 Sprinter 3500 engines | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Popular Fits: all 2021 Sprinter 3500 engines | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Sprinter 3500 engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PEAK Fits: all 2021 Sprinter 3500 engines | FXA1GAL | 🇺🇸 US 🇨🇦 CA | Final Charge Global1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 Sprinter 3500 engines | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 Sprinter 3500 engines | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 Sprinter 3500 engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Sprinter 3500 engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 Sprinter 3500 engines | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VALVOLINE Popular Fits: all 2021 Sprinter 3500 engines | 861399 | 🇺🇸 US 🇨🇦 CA | G40 Pink1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Sprinter 3500 engines | PEV1GAL | 🇺🇸 US 🇨🇦 CA | OET European Extended Life Violet1 Gallon | View on Amazon |
| PENTOSIN Fits: all 2021 Sprinter 3500 engines | 8114306 | 🇺🇸 US 🇨🇦 CA | Pentofrost E1 Gallon | View on Amazon |
| PENTOSIN Fits: all 2021 Sprinter 3500 engines | 8113106 | 🇺🇸 US 🇨🇦 CA | Pentofrost E1.5 Liters | View on Amazon |
| PENTOSIN Fits: all 2021 Sprinter 3500 engines | 8113206 | 🇺🇸 US 🇨🇦 CA | Pentofrost E5 Liters | View on Amazon |
| VALVOLINE Fits: all 2021 Sprinter 3500 engines | 877981 | 🇺🇸 US 🇨🇦 CA | G30 Purple1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
16 Coolant / Antifreeze parts are listed for the 2021 Freightliner Sprinter 3500, from PRESTONE, PEAK, VALVOLINE and 1 other brand. PRESTONE AF3100 carries the "Popular" badge. All of them fit every engine offered in the 2021 Sprinter 3500.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, PRESTONE, VALVOLINE and PEAK supply 3 parts: the catalog's value-priced group. A representative part number is PRESTONE AF3100.
The Heavy Duty section lists 2 options from PEAK and PRESTONE — rated for severe service. PEAK FXA1GAL is listed in this group.
The Premium section lists 4 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 6 options from PENTOSIN, VALVOLINE and PEAK — built to original-equipment specification. VALVOLINE 861399 is listed in this group.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: 2.1L L4 DIESEL Turbocharged | CHE0975 | 🇺🇸 US 🇨🇦 CA | Water Outlet To Thermostat Housing | View on Amazon |
| REIN Fits: 2.1L L4 DIESEL Turbocharged | CHE0891 | 🇺🇸 US 🇨🇦 CA | Oil Cooler To Pipe | View on Amazon |
| REIN Fits: 2.1L L4 DIESEL Turbocharged | CHE0889 | 🇺🇸 US 🇨🇦 CA | EGR Cooler To Valve | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
REIN supplies the 3 Coolant Hose / Pipe parts for the 2021 Freightliner Sprinter 3500.
This group includes REIN CHE0975, REIN CHE0891 and REIN CHE0889.
Coolant Hose Connector / Flange Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING Fits: 3.0L V6 DIESEL Turbocharged | 540890 | 🇺🇸 US 🇨🇦 CA | CrankcaseInlet Flange Seal | View on Amazon |
This table covers the seals at the Coolant Hose Connector / Flange. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
This group shows a single part: ELRING 540890.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: all 2021 Sprinter 3500 engines | CPE0029P | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
This group shows a single part: REIN CPE0029P.
Intercooler
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: all 2021 Sprinter 3500 engines | 2711574 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SPECTRA PREMIUM Fits: 2.1L L4 DIESEL Turbocharged | 44012411 | 🇺🇸 US 🇨🇦 CA | Charge Air Coolers | View on Amazon |
This table covers the intercoolers that cool turbo or supercharger charge air.
2 Intercooler parts are listed for the 2021 Freightliner Sprinter 3500, from GPD and SPECTRA PREMIUM. 1 part fits every engine; the other 1 is engine-specific.
Part numbers include GPD 2711574 and SPECTRA PREMIUM 44012411.
Intercooler Air Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN Fits: 3.0L V6 DIESEL Turbocharged | TCH0330 | 🇺🇸 US 🇨🇦 CA | Left | View on Amazon |
This table covers the Intercooler Air Hose pipes.
One part is listed for the 2021 Freightliner Sprinter 3500 — REIN TCH0330.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DAYCO Fits: 2.1L L4 DIESEL Turbocharged | 72814 | 🇺🇸 US 🇨🇦 CA | Curved | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
This group shows a single part: DAYCO 72814.
Buying Cooling System Parts for a 2021 Freightliner Sprinter 3500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Coolant Hose / Pipe .
Frequently Asked Questions
How many cooling system parts fit the 2021 Freightliner Sprinter 3500?
Our catalog currently lists 25 cooling system parts for the 2021 Freightliner Sprinter 3500 across 7 subcategories and 9 brands, covering both the 2.1L L4 DIESEL Turbocharged and the 3.0L V6 DIESEL Turbocharged. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 Freightliner Sprinter 3500 engines?
Some do. 18 parts fit every engine; the other 7 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 Freightliner Sprinter 3500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Freightliner Sprinter 3500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Freightliner Sprinter 3500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Freightliner Sprinter 3500
Cooling System Parts for Other Freightliner Sprinter 3500 Years
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