This page lists 86 cooling system parts for the 2021 GMC Savana 2500, across 23 part types, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Every part shows its brand, manufacturer part number and fitment notes.
On the 2021 GMC Savana 2500, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. 39 parts of the 86 listed are Coolant / Antifreeze (17 parts), Thermostat (14 parts) and Temperature Sender / Sensor (8 parts). The other 20 part types cover the remaining 47 parts.
The 2021 GMC Savana 2500 was sold with 3 engines. Every part on this page is engine-specific. Each part shows which engine(s) it fits.
27 brands supply cooling system parts for the 2021 GMC Savana 2500, led by GM GENUINE (20 parts), MOTORAD (12 parts) and PRESTONE (7 parts), plus 24 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 GMC Savana 2500. 10 parts have it, including FVP MV5050GAL (Coolant / Antifreeze) and DORMAN 54218 (Coolant Reservoir Cap). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 6.6L V8 | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Popular Fits: 6.6L V8 | MV5050GAL | 🇺🇸 US 🇨🇦 CA | Extended LifeAll Makes / All Models | View on Amazon |
| PEAK Fits: 6.6L V8 | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Fits: 6.6L V8 | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 6.6L V8 | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: 6.6L V8 | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: 6.6L V8 | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: 6.6L V8 | PXA1GAL | 🇺🇸 US 🇨🇦 CA | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 6.6L V8 | 105027 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon | View on Amazon |
| VALVOLINE Popular Fits: 6.6L V8 | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| AISIN Fits: 6.6L V8 | ACD005 | 🇺🇸 US 🇨🇦 CA | OrangeOAT | View on Amazon |
| FVP Fits: 6.6L V8 | DEX5050GAL | 🇺🇸 US 🇨🇦 CA | Extended Life Blend1 Gallon | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AF3400 | 🇺🇸 US 🇨🇦 CA | Prime OrangeOrange Compatible | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AF850 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended Life1 Gallon | View on Amazon |
| VALVOLINE Fits: 6.6L V8 | 888374 | 🇺🇸 US 🇨🇦 CA | American Vehicle Orange1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
17 Coolant / Antifreeze parts are listed for the 2021 GMC Savana 2500, from PRESTONE, PEAK, VALVOLINE and 3 other brands. FVP MV5050GAL carries the "Popular" badge.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, FVP, PEAK, PRESTONE and 1 other brand supply 4 parts: the catalog's value-priced group. A representative part number is FVP MV5050GAL.
The Heavy Duty section lists 1 option from PRESTONE — rated for severe service. PRESTONE AFC12100 is listed in this group.
The Premium section lists 4 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 7 options from VALVOLINE, PRESTONE, ACDELCO and 2 other brands — built to original-equipment specification. ACDELCO 105027 is listed in this group.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 25866165 | 🇺🇸 US 🇨🇦 CA | InletOn Reservoir | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 84882346 | 🇺🇸 US 🇨🇦 CA | Expansion tank to radiator | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
GM GENUINE supplies both parts for the 2021 GMC Savana 2500.
This group includes GM GENUINE 25866165 and GM GENUINE 84882346.
Coolant Hose Connector / Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 1510595 | 🇺🇸 US 🇨🇦 CA | 6 speed Automatic trans. | View on Amazon |
This table covers the Coolant Hose Connector flanges.
One part is listed for the 2021 GMC Savana 2500 — GM GENUINE 1510595.
Coolant Hose Retainer / Clip
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 11547271 | 🇺🇸 US 🇨🇦 CA | InletTie Strap with Clip | View on Amazon |
This table covers the Coolant Hose retainers and clips.
One part is listed for the 2021 GMC Savana 2500 — GM GENUINE 11547271.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 | 603078 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 | 85604316 | 🇺🇸 US 🇨🇦 CA | Reservoir Material: Polypropylene (PP) | View on Amazon |
| GPD Fits: 6.6L V8 | 2411182 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
3 Coolant Reservoir parts for the 2021 GMC Savana 2500 come from 3 brands — DORMAN, GM GENUINE and GPD.
Listed part numbers: DORMAN 603078, GM GENUINE 85604316 and GPD 2411182.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Popular Fits: 6.6L V8 | 54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| CALORSTAT Fits: 6.6L V8 | RC0147 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 15.0 PS | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | RC122 | 🇺🇸 US 🇨🇦 CA | Exc. Coolant Cap with Tether(9C7) | View on Amazon |
| MOTORAD Fits: 6.6L V8 | T80 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
| SKP Fits: 6.6L V8 | SK54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
5 Coolant Reservoir Cap parts for the 2021 GMC Savana 2500 come from 5 brands — DORMAN, CALORSTAT, GM GENUINE and 2 other brands. The "Popular" part is DORMAN 54218.
Listed part numbers: DORMAN 54218, CALORSTAT RC0147 and GM GENUINE RC122, plus the other parts above.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 90530642 | 🇺🇸 US 🇨🇦 CA | Fits Clamp-Sprindband, 14X12, Double BandAir Bleed Hos | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 11603888 | 🇺🇸 US 🇨🇦 CA | Adjustment Type: YES | View on Amazon |
This table covers the Hose clamps.
GM GENUINE supplies both parts for the 2021 GMC Savana 2500.
Listed part numbers: GM GENUINE 90530642 and GM GENUINE 11603888.
Intercooler Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 19130019 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the seals at the Intercooler. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
This group shows a single part: GM GENUINE 19130019.
Radiator
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Fits: 6.6L V8 | 4021 | 🇺🇸 US 🇨🇦 CA | with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings. | View on Amazon |
| FVP Fits: 6.6L V8 | RAD14058 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 | 84916454 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
3 Radiator parts are listed for the 2021 GMC Savana 2500, from CSF, FVP and GM GENUINE.
This group includes CSF 4021, FVP RAD14058 and GM GENUINE 84916454.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 | RC85 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Fits: 6.6L V8 | 31532 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Fits: 6.6L V8 | T46 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
3 Radiator Cap parts are listed for the 2021 GMC Savana 2500, from ACDELCO, GATES and MOTORAD.
This group includes ACDELCO RC85, GATES 31532 and MOTORAD T46.
Radiator Drain Petcock
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 22790134 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the petcocks used to drain the radiator.
This group shows a single part: GM GENUINE 22790134.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 | 84723175 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 86532393 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
2 Radiator Fan Blade parts for the 2021 GMC Savana 2500 come from 2 brands — ACDELCO and GM GENUINE.
Listed part numbers: ACDELCO 84723175 and GM GENUINE 86532393.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 6.6L V8 | 46145 | 🇺🇸 US 🇨🇦 CA | Severe Duty Thermal | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 84595910 | 🇺🇸 US 🇨🇦 CA | Thermal | View on Amazon |
| HAYDEN Fits: 6.6L V8 | 2984 | 🇺🇸 US 🇨🇦 CA | ThermalSevere Duty | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
3 Radiator Fan Clutch parts are listed for the 2021 GMC Savana 2500, from FOUR SEASONS, GM GENUINE and HAYDEN.
Part numbers include FOUR SEASONS 46145, GM GENUINE 84595910 and HAYDEN 2984.
Radiator Fan Motor Bracket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 24591472 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.
One part is listed for the 2021 GMC Savana 2500 — GM GENUINE 24591472.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 84145362 | 🇺🇸 US 🇨🇦 CA | Rearward | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
One part is listed for the 2021 GMC Savana 2500 — GM GENUINE 84145362.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 | 85144276 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| ACDELCO Fits: 6.6L V8 | 84882345 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| ACDELCO Fits: 6.6L V8 | 84984107 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
3 Radiator Hose parts for the 2021 GMC Savana 2500 come from ACDELCO.
Listed part numbers: ACDELCO 85144276, ACDELCO 84882345 and ACDELCO 84984107.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ULTRA-POWER Popular Fits: 6.6L V8 | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.6L V8 | 1712496 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: 6.6L V8 | 2CTS0184 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| STANDARD MOTOR PRODUCTS Popular Fits: 6.6L V8 | TX247 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FACET Fits: 6.6L V8 | 73379 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Oblong | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 25186240 | 🇺🇸 US 🇨🇦 CA | 6 speed Automatic trans.THREADS IN BLOCK | View on Amazon |
| WALKER PRODUCTS Fits: 6.6L V8 | 2112015 | 🇺🇸 US 🇨🇦 CA | SensorIncludes O-Ring | View on Amazon |
| WELLS Fits: 6.6L V8 | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
8 Temperature Sender / Sensor parts are listed for the 2021 GMC Savana 2500, from ULTRA-POWER, GPD, HOLSTEIN and 5 other brands. ULTRA-POWER 5S13427 carries the "Popular" badge.
Economy: 3 parts, from ULTRA-POWER, GPD and HOLSTEIN. A representative part number is ULTRA-POWER 5S13427.
The Standard Replacement section: 5 options from STANDARD MOTOR PRODUCTS, FACET, GM GENUINE and 2 other brands. STANDARD MOTOR PRODUCTS TX247 is listed in this group.
This group includes ULTRA-POWER 5S13427, GPD 1712496 and HOLSTEIN 2CTS0184 and the remaining parts above.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AUTOTECNICA Fits: 6.6L V8 | GM0718523 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| DORMAN Fits: 6.6L V8 | 9022981 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| SKP Fits: 6.6L V8 | SK131160 | 🇺🇸 US 🇨🇦 CA | 190 Degree | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.6L V8 | 5523187 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 5523160 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.6L V8 | 2523160 | 🇺🇸 US 🇨🇦 CA | High FlowIncludes seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | MRD105 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 6.6L V8 | 131160 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Popular Fits: 6.6L V8 | 34198 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 | 523160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 523190 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 523174 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 523180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 5945KT | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and HousingKit | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
14 Thermostat parts for the 2021 GMC Savana 2500 come from 6 brands — MOTORAD, AUTOTECNICA, DORMAN and 3 other brands. The "Popular" part is ACDELCO 131160.
The Economy section: 3 options from AUTOTECNICA, DORMAN and SKP. AUTOTECNICA GM0718523 is listed in this group.
Heavy Duty: 2 parts, from MOTORAD. A representative part number is MOTORAD 5523187.
The Performance section lists 2 options from MOTORAD — engineered beyond original-equipment specification. MOTORAD 2523160 is listed in this group.
Standard Replacement: 7 parts, from MOTORAD, ACDELCO and GATES. A representative part number is ACDELCO 131160.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.6L V8 | 36219 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| VICTOR REINZ Fits: 6.6L V8 | 711357800 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
2 Thermostat / Thermostat Housing / Water Outlet Seal parts are listed for the 2021 GMC Savana 2500, from FEL-PRO and VICTOR REINZ.
This group includes FEL-PRO 36219 and VICTOR REINZ 711357800.
Thermostat Housing / Water Outlet
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 | 9022081 | 🇺🇸 US 🇨🇦 CA | Water PumpThermostat Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 6.6L V8 | 85945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| GATES Fits: 6.6L V8 | CO34829 | 🇺🇸 US 🇨🇦 CA | Thermostat CoverWater Outlet | View on Amazon |
| MOTORAD Fits: 6.6L V8 | CH5945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
4 Thermostat Housing / Water Outlet parts for the 2021 GMC Savana 2500 come from 4 brands — DORMAN, FOUR SEASONS, GATES and 1 other brand.
The Economy section: 1 option from DORMAN. DORMAN 9022081 is listed in this group.
Standard Replacement: 3 parts, from FOUR SEASONS, GATES and MOTORAD. A representative part number is FOUR SEASONS 85945.
Listed part numbers: DORMAN 9022081, FOUR SEASONS 85945 and GATES CO34829, plus the other parts above.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 12587397 | 🇺🇸 US 🇨🇦 CA | 6 speed Automatic trans. | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 12650512 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
GM GENUINE supplies both parts for the 2021 GMC Savana 2500.
Part numbers include GM GENUINE 12587397 and GM GENUINE 12650512.
Water Pump
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Fits: 6.6L V8 | 1303210 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 | 12735409 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat | View on Amazon |
| GMB Fits: 6.6L V8 | 1303210 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
3 Water Pump parts for the 2021 GMC Savana 2500 come from 3 brands — FVP, GM GENUINE and GMB.
Part numbers include FVP 1303210 and GM GENUINE 12735409, among others listed above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.6L V8 | 36110 | 🇺🇸 US 🇨🇦 CA | To BlockHousing To Block | View on Amazon |
| FEL-PRO Fits: 6.6L V8 | 36109 | 🇺🇸 US 🇨🇦 CA | To BlockPump To Housing | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 2512073 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MAHLE / CLEVITE Fits: 6.6L V8 | K33358 | 🇺🇸 US 🇨🇦 CA | SteelIncludes 2 Gaskets | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
4 Water Pump Gasket parts are listed for the 2021 GMC Savana 2500, from FEL-PRO, GM GENUINE and MAHLE / CLEVITE.
Listed part numbers: FEL-PRO 36110, FEL-PRO 36109 and GM GENUINE 2512073, plus the other parts above.
Buying Cooling System Parts for a 2021 GMC Savana 2500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Every cooling system part here is engine-specific; each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Thermostat .
Frequently Asked Questions
How many cooling system parts fit the 2021 GMC Savana 2500?
Our catalog currently lists 86 cooling system parts for the 2021 GMC Savana 2500 across 23 subcategories and 27 brands, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 GMC Savana 2500 engines?
Yes. Every cooling system part on this page is engine-specific. Each row shows which engine(s) it fits — use the filter at the top to hide the rest. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 GMC Savana 2500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 GMC Savana 2500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 GMC Savana 2500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 GMC Savana 2500
Cooling System Parts for Other GMC Savana 2500 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.