The 2021 GMC Savana 3500 has 100 cooling system parts with verified fitment on this page — 23 part types and 33 brands, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Each part includes a manufacturer part number and application notes.
On the 2021 GMC Savana 3500, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. Most of the listed parts are Coolant / Antifreeze (17 parts), Thermostat (17 parts) and Temperature Sender / Sensor (8 parts). The other 20 part types cover the remaining 58 parts.
The 2021 GMC Savana 3500 was sold with 3 engines. Every part on this page is engine-specific. Each part shows which engine(s) it fits.
The most listed brands for 2021 GMC Savana 3500 cooling system parts are GM GENUINE (24 parts), MOTORAD (12 parts) and PRESTONE (7 parts), plus 30 more brands. Quality grades include Standard Replacement, Economy and Premium.
15 parts on this 2021 GMC Savana 3500 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including FVP MV5050GAL (Coolant / Antifreeze) and GM GENUINE 21939 (Radiator). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 4.3L V6 | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Popular Fits: 4.3L V6 | MV5050GAL | 🇺🇸 US 🇨🇦 CA | Extended LifeAll Makes / All Models | View on Amazon |
| PEAK Fits: 4.3L V6 | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE Fits: 4.3L V6 | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Fits: 4.3L V6 | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 4.3L V6 | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: 4.3L V6 | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: 4.3L V6 | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: 4.3L V6 | PXA1GAL | 🇺🇸 US 🇨🇦 CA | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: 4.3L V6 | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 4.3L V6 | 105027 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon | View on Amazon |
| VALVOLINE Popular Fits: 4.3L V6 | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| AISIN Fits: 4.3L V6 | ACD005 | 🇺🇸 US 🇨🇦 CA | OrangeOAT | View on Amazon |
| FVP Fits: 4.3L V6 | DEX5050GAL | 🇺🇸 US 🇨🇦 CA | Extended Life Blend1 Gallon | View on Amazon |
| PRESTONE Fits: 4.3L V6 | AF3400 | 🇺🇸 US 🇨🇦 CA | Prime OrangeOrange Compatible | View on Amazon |
| PRESTONE Fits: 4.3L V6 | AF850 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended Life1 Gallon | View on Amazon |
| VALVOLINE Fits: 4.3L V6 | 888374 | 🇺🇸 US 🇨🇦 CA | American Vehicle Orange1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
17 Coolant / Antifreeze parts for the 2021 GMC Savana 3500 come from 6 brands — PRESTONE, PEAK, VALVOLINE and 3 other brands. The "Popular" part is FVP MV5050GAL.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 4 options from FVP, PEAK, PRESTONE and 1 other brand — the catalog's value-priced group. FVP MV5050GAL is listed in this group.
In the Heavy Duty grade, PRESTONE supplies 1 part: rated for severe service. A representative part number is PRESTONE AFC12100.
In the Premium grade, PRESTONE and PEAK supply 4 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, VALVOLINE, PRESTONE, ACDELCO and 2 other brands supply 7 parts: built to original-equipment specification. A representative part number is ACDELCO 105027.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 25866165 | 🇺🇸 US 🇨🇦 CA | InletOn Reservoir | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 84443244 | 🇺🇸 US 🇨🇦 CA | Expansion Tank To Radiator135.0" Wheelbase or 139.0" Wheelbase or 155.0" Wheelbase | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
2 Coolant Hose / Pipe parts for the 2021 GMC Savana 3500 come from GM GENUINE.
Listed part numbers: GM GENUINE 25866165 and GM GENUINE 84443244.
Coolant Hose Connector / Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 1510595 | 🇺🇸 US 🇨🇦 CA | 8 speed Automatic trans. | View on Amazon |
This table covers the Coolant Hose Connector flanges.
This group shows a single part: GM GENUINE 1510595.
Coolant Hose Retainer / Clip
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 11547445 | 🇺🇸 US 🇨🇦 CA | 135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseOmega Clip | View on Amazon |
This table covers the Coolant Hose retainers and clips.
This group shows a single part: GM GENUINE 11547445.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 4.3L V6 | 603078 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 4.3L V6 | 85604316 | 🇺🇸 US 🇨🇦 CA | Reservoir Material: Polypropylene (PP) | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 85666315 | 🇺🇸 US 🇨🇦 CA | Reservoir Material: Polypropylene (PP) | View on Amazon |
| GPD Fits: 4.3L V6 | 2411182 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
4 Coolant Reservoir parts are listed for the 2021 GMC Savana 3500, from GM GENUINE, DORMAN and GPD.
Part numbers include DORMAN 603078, GM GENUINE 85604316 and GM GENUINE 85666315, among others listed above.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CALORSTAT Fits: 4.3L V6 | RC0147 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 15.0 PS | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | RC121 | 🇺🇸 US 🇨🇦 CA | Pressure Release Lever: No | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | RC122 | 🇺🇸 US 🇨🇦 CA | Exc. Coolant Cap with Tether(9C7) | View on Amazon |
| MOTORAD Fits: 4.3L V6 | T80 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
4 Coolant Reservoir Cap parts are listed for the 2021 GMC Savana 3500, from GM GENUINE, CALORSTAT and MOTORAD.
Listed part numbers: CALORSTAT RC0147, GM GENUINE RC121 and GM GENUINE RC122, plus the other parts above.
Coolant Reservoir Retainer / Clip
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 10121502 | 🇺🇸 US 🇨🇦 CA | Cutaway VanHead OD=17.8, Length | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 23382103 | 🇺🇸 US 🇨🇦 CA | Cutaway VanCoolant Cap with Tether(9C7) | View on Amazon |
This table covers the Coolant Reservoir retainers and clips.
2 Coolant Reservoir Retainer / Clip parts for the 2021 GMC Savana 3500 come from GM GENUINE.
Part numbers include GM GENUINE 10121502 and GM GENUINE 23382103.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 11548759 | 🇺🇸 US 🇨🇦 CA | RESERVOIR HOSE | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 90530642 | 🇺🇸 US 🇨🇦 CA | 135.0" Wheelbase or 139.0" Wheelbase or 155.0" WheelbaseClamp-Sprindband, 14X12, Double Band | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 86308358 | 🇺🇸 US 🇨🇦 CA | Coolant Cap with Tether(9C7)Reservoir Hose | View on Amazon |
This table covers the Hose clamps.
3 Hose Clamp parts for the 2021 GMC Savana 3500 come from GM GENUINE.
Listed part numbers: GM GENUINE 11548759, GM GENUINE 90530642 and GM GENUINE 86308358.
Intercooler Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 19130019 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the seals at the Intercooler. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2021 GMC Savana 3500 — GM GENUINE 19130019.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: 4.3L V6 | 2791C | 🇺🇸 US 🇨🇦 CA | without Sensor Port | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 4.3L V6 | 21939 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| CSF Fits: 4.3L V6 | 4023 | 🇺🇸 US 🇨🇦 CA | 11% Thicker Core 30mm vs OEM 27mm. with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings | View on Amazon |
| SPECTRA PREMIUM Fits: 4.3L V6 | CU13867 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UAC Fits: 4.3L V6 | RA13867C | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
5 Radiator parts for the 2021 GMC Savana 3500 come from 5 brands — GPD, GM GENUINE, CSF and 2 other brands. The "Popular" part is GM GENUINE 21939.
The Economy section: 1 option from GPD. GPD 2791C is listed in this group.
Standard Replacement: 4 parts, from GM GENUINE, CSF, SPECTRA PREMIUM and 1 other brand. A representative part number is GM GENUINE 21939.
Part numbers include GM GENUINE 21939, GPD 2791C and CSF 4023, among others listed above.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 4.3L V6 | RC85 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Fits: 4.3L V6 | 31532 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Fits: 4.3L V6 | T46 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
3 Radiator Cap parts for the 2021 GMC Savana 3500 come from 3 brands — ACDELCO, GATES and MOTORAD.
This group includes ACDELCO RC85, GATES 31532 and MOTORAD T46.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 4.3L V6 | 1581941 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 86532392 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| VARIOUS MFR Fits: 4.3L V6 | GM3112129 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
3 Radiator Fan Blade parts are listed for the 2021 GMC Savana 3500, from ACDELCO, GM GENUINE and VARIOUS MFR.
Part numbers include ACDELCO 1581941, GM GENUINE 86532392 and VARIOUS MFR GM3112129.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 4.3L V6 | 46144 | 🇺🇸 US 🇨🇦 CA | Severe Duty Thermal | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 1540585 | 🇺🇸 US 🇨🇦 CA | Thermal | View on Amazon |
| HAYDEN Fits: 4.3L V6 | 2983 | 🇺🇸 US 🇨🇦 CA | ThermalSevere Duty | View on Amazon |
| US MOTOR WORKS Fits: 4.3L V6 | 22169 | 🇺🇸 US 🇨🇦 CA | Thermal | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
4 Radiator Fan Clutch parts for the 2021 GMC Savana 3500 come from 4 brands — FOUR SEASONS, GM GENUINE, HAYDEN and 1 other brand.
Part numbers include FOUR SEASONS 46144, GM GENUINE 1540585 and HAYDEN 2983, among others listed above.
Radiator Fan Motor Bracket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 24591472 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.
This group shows a single part: GM GENUINE 24591472.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 84362765 | 🇺🇸 US 🇨🇦 CA | Rearward | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
This group shows a single part: GM GENUINE 84362765.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 4.3L V6 | 84186464 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
One part is listed for the 2021 GMC Savana 3500 — ACDELCO 84186464.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ULTRA-POWER Popular Fits: 4.3L V6 | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 4.3L V6 | 1712496 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: 4.3L V6 | 2CTS0184 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| STANDARD MOTOR PRODUCTS Popular Fits: 4.3L V6 | TX247 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FACET Fits: 4.3L V6 | 73379 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Oblong | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 25186240 | 🇺🇸 US 🇨🇦 CA | 8 speed Automatic trans.THREADS IN BLOCK | View on Amazon |
| WALKER PRODUCTS Fits: 4.3L V6 | 2112015 | 🇺🇸 US 🇨🇦 CA | SensorIncludes O-Ring | View on Amazon |
| WELLS Fits: 4.3L V6 | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
8 Temperature Sender / Sensor parts for the 2021 GMC Savana 3500 come from 8 brands — ULTRA-POWER, GPD, HOLSTEIN and 5 other brands. The "Popular" part is ULTRA-POWER 5S13427.
The Economy section: 3 options from ULTRA-POWER, GPD and HOLSTEIN. ULTRA-POWER 5S13427 is listed in this group.
Standard Replacement: 5 parts, from STANDARD MOTOR PRODUCTS, FACET, GM GENUINE and 2 other brands. A representative part number is STANDARD MOTOR PRODUCTS TX247.
Part numbers include ULTRA-POWER 5S13427, GPD 1712496 and HOLSTEIN 2CTS0184, among others listed above.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AUTOTECNICA Fits: 4.3L V6 | GM0718523 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| DORMAN Fits: 4.3L V6 | 9022981 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| SKP Fits: 4.3L V6 | SK131160 | 🇺🇸 US 🇨🇦 CA | 190 Degree | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 4.3L V6 | 5523187 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
| MOTORAD Fits: 4.3L V6 | 5523160 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 4.3L V6 | 2523160 | 🇺🇸 US 🇨🇦 CA | High FlowIncludes seal | View on Amazon |
| MOTORAD Fits: 4.3L V6 | MRD105 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 4.3L V6 | 131160 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Popular Fits: 4.3L V6 | 34198 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Popular Fits: 4.3L V6 | 523190 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 4.3L V6 | 523160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| AISIN Fits: 4.3L V6 | THRGM0002 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat SealWithout Integrated Housing | View on Amazon |
| CALORSTAT Fits: 4.3L V6 | TH210786J | 🇺🇸 US 🇨🇦 CA | Includes 1 Rubber Gasket | View on Amazon |
| CALORSTAT Fits: 4.3L V6 | TH210782J | 🇺🇸 US 🇨🇦 CA | PerformanceIncludes 1 Rubber Gasket | View on Amazon |
| MOTORAD Fits: 4.3L V6 | 523174 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 4.3L V6 | 523180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 4.3L V6 | 5945KT | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and HousingKit | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
17 Thermostat parts are listed for the 2021 GMC Savana 3500, from MOTORAD, CALORSTAT, AUTOTECNICA and 5 other brands. ACDELCO 131160 carries the "Popular" badge.
Economy: 3 parts, from AUTOTECNICA, DORMAN and SKP. A representative part number is AUTOTECNICA GM0718523.
The Heavy Duty section: 2 options from MOTORAD. MOTORAD 5523187 is listed in this group.
In the Performance grade, MOTORAD supplies 2 parts: engineered beyond original-equipment specification. A representative part number is MOTORAD 2523160.
The Standard Replacement section: 10 options from MOTORAD, CALORSTAT, ACDELCO and 2 other brands. ACDELCO 131160 is listed in this group.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Popular Fits: 4.3L V6 | 36219 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| FEL-PRO Popular Fits: 4.3L V6 | 36106 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing Seal | View on Amazon |
| APEX Fits: 4.3L V6 | AWO2386 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 4.3L V6 | C32061 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| MAHLE / CLEVITE Fits: 4.3L V6 | C32719 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| VICTOR REINZ Fits: 4.3L V6 | 711357800 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
6 Thermostat / Thermostat Housing / Water Outlet Seal parts for the 2021 GMC Savana 3500 come from 4 brands — FEL-PRO, MAHLE / CLEVITE, APEX and 1 other brand. The "Popular" part is FEL-PRO 36219.
Listed part numbers: FEL-PRO 36219, FEL-PRO 36106 and APEX AWO2386, plus the other parts above.
Thermostat Housing / Water Outlet
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 4.3L V6 | 9022081 | 🇺🇸 US 🇨🇦 CA | Water PumpThermostat Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 4.3L V6 | 85945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| GATES Fits: 4.3L V6 | CO34829 | 🇺🇸 US 🇨🇦 CA | Thermostat CoverWater Outlet | View on Amazon |
| MOTORAD Fits: 4.3L V6 | CH5945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
4 Thermostat Housing / Water Outlet parts are listed for the 2021 GMC Savana 3500, from DORMAN, FOUR SEASONS, GATES and 1 other brand.
Economy: 1 part, from DORMAN. A representative part number is DORMAN 9022081.
The Standard Replacement section: 3 options from FOUR SEASONS, GATES and MOTORAD. FOUR SEASONS 85945 is listed in this group.
Part numbers include DORMAN 9022081, FOUR SEASONS 85945 and GATES CO34829, among others listed above.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 4.3L V6 | 12587397 | 🇺🇸 US 🇨🇦 CA | 8 speed Automatic trans. | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 12650512 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
2 Water Inlet Gasket parts for the 2021 GMC Savana 3500 come from GM GENUINE.
This group includes GM GENUINE 12587397 and GM GENUINE 12650512.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| WJB / INMOTION PARTS Fits: 4.3L V6 | WU1303160 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular Fits: 4.3L V6 | 45073 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat | View on Amazon |
| FVP Fits: 4.3L V6 | 1303160 | 🇺🇸 US 🇨🇦 CA | Water Pump Drive Type: Serpentine Belt | View on Amazon |
| GM GENUINE Fits: 4.3L V6 | 12740339 | 🇺🇸 US 🇨🇦 CA | 8 speed Automatic trans. | View on Amazon |
| GMB Fits: 4.3L V6 | 1303160 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
5 Water Pump parts are listed for the 2021 GMC Savana 3500, from WJB / INMOTION PARTS, GATES, FVP and 2 other brands. GATES 45073 carries the "Popular" badge.
Economy: 1 part, from WJB / INMOTION PARTS. A representative part number is WJB / INMOTION PARTS WU1303160.
The Standard Replacement section: 4 options from GATES, FVP, GM GENUINE and 1 other brand. GATES 45073 is listed in this group.
Listed part numbers: GATES 45073, WJB / INMOTION PARTS WU1303160 and FVP 1303160, plus the other parts above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 4.3L V6 | 2512073 | 🇺🇸 US 🇨🇦 CA | 8 speed Automatic trans. | View on Amazon |
| APEX Fits: 4.3L V6 | AWP3308 | 🇺🇸 US 🇨🇦 CA | Water Pump To Block | View on Amazon |
| APEX Fits: 4.3L V6 | AWP3307 | 🇺🇸 US 🇨🇦 CA | Water pump housing | View on Amazon |
| FEL-PRO Fits: 4.3L V6 | 36110 | 🇺🇸 US 🇨🇦 CA | To BlockHousing To Block | View on Amazon |
| FEL-PRO Fits: 4.3L V6 | 36109 | 🇺🇸 US 🇨🇦 CA | To BlockPump To Housing | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
5 Water Pump Gasket parts for the 2021 GMC Savana 3500 come from 3 brands — APEX, FEL-PRO and GM GENUINE. The "Popular" part is GM GENUINE 2512073.
Part numbers include GM GENUINE 2512073, APEX AWP3308 and APEX AWP3307, among others listed above.
Buying Cooling System Parts for a 2021 GMC Savana 3500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Every cooling system part here is engine-specific; each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Thermostat .
Frequently Asked Questions
How many cooling system parts fit the 2021 GMC Savana 3500?
Our catalog currently lists 100 cooling system parts for the 2021 GMC Savana 3500 across 23 subcategories and 33 brands, covering all 3 engine options (2.8L L4 DIESEL Turbocharged, 4.3L V6 and 6.6L V8). Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 GMC Savana 3500 engines?
Yes. Every cooling system part on this page is engine-specific. Each row shows which engine(s) it fits — use the filter at the top to hide the rest. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 GMC Savana 3500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 GMC Savana 3500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 GMC Savana 3500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 GMC Savana 3500
Cooling System Parts for Other GMC Savana 3500 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.