This page lists 167 cooling system parts for the 2021 GMC Sierra 2500, across 31 part types, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Every part shows its brand, manufacturer part number and fitment notes.
The cooling system system on the 2021 GMC Sierra 2500 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Thermostat (27 parts), Coolant / Antifreeze (17 parts) and Radiator (14 parts). The other 28 part types cover the remaining 109 parts.
The 2021 GMC Sierra 2500 was sold with both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. 38 parts fit every engine; the other 129 are engine-specific. Each part shows which engine(s) it fits.
36 brands supply cooling system parts for the 2021 GMC Sierra 2500, led by GM GENUINE (56 parts), MOTORAD (19 parts) and ACDELCO (8 parts), plus 33 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 GMC Sierra 2500. 23 parts have it, including FVP MV5050GAL (Coolant / Antifreeze) and GM GENUINE 85119168 (Coolant Hose / Pipe). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 6.6L V8 DIESEL Turbocharged | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Popular Fits: all 2021 Sierra 2500 engines | MV5050GAL | 🇺🇸 US 🇨🇦 CA | Extended LifeAll Makes / All Models | View on Amazon |
| PEAK Fits: all 2021 Sierra 2500 engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE Fits: 6.6L V8 DIESEL Turbocharged | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Fits: all 2021 Sierra 2500 engines | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 Sierra 2500 engines | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: 6.6L V8 DIESEL Turbocharged | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 Sierra 2500 engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Sierra 2500 engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: 6.6L V8 DIESEL Turbocharged | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: all 2021 Sierra 2500 engines | 105027 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon | View on Amazon |
| VALVOLINE Popular Fits: all 2021 Sierra 2500 engines | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| AISIN Fits: all 2021 Sierra 2500 engines | ACD005 | 🇺🇸 US 🇨🇦 CA | OrangeOAT | View on Amazon |
| FVP Fits: all 2021 Sierra 2500 engines | DEX5050GAL | 🇺🇸 US 🇨🇦 CA | Extended Life Blend1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 Sierra 2500 engines | AF3400 | 🇺🇸 US 🇨🇦 CA | Prime OrangeOrange Compatible | View on Amazon |
| PRESTONE Fits: all 2021 Sierra 2500 engines | AF850 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended Life1 Gallon | View on Amazon |
| VALVOLINE Fits: all 2021 Sierra 2500 engines | 888374 | 🇺🇸 US 🇨🇦 CA | American Vehicle Orange1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
17 Coolant / Antifreeze parts are listed for the 2021 GMC Sierra 2500, from PRESTONE, PEAK, VALVOLINE and 3 other brands. FVP MV5050GAL carries the "Popular" badge. 13 parts fit every engine; the other 4 are engine-specific.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, FVP, PEAK, PRESTONE and 1 other brand supply 4 parts: the catalog's value-priced group. A representative part number is FVP MV5050GAL.
The Heavy Duty section lists 1 option from PRESTONE — rated for severe service. PRESTONE AFC12100 is listed in this group.
The Premium section lists 4 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 7 options from VALVOLINE, PRESTONE, ACDELCO and 2 other brands — built to original-equipment specification. ACDELCO 105027 is listed in this group.
Coolant Air Bleed Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 85056536 | 🇺🇸 US 🇨🇦 CA | Shape: Molded Assembly | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549085 | 🇺🇸 US 🇨🇦 CA | CLAMP, SPRINGBAND, 13MM DIAMETER X 12 WIDE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056532 | 🇺🇸 US 🇨🇦 CA | Shape: Molded Assembly | View on Amazon |
This table covers the Coolant Air Bleed Hose pipes.
GM GENUINE supplies the 3 Coolant Air Bleed Hose / Pipe parts for the 2021 GMC Sierra 2500.
Part numbers include GM GENUINE 85056536, GM GENUINE 11549085 and GM GENUINE 85056532.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 85119168 | 🇺🇸 US 🇨🇦 CA | Expansion Tank Outlet | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 85056538 | 🇺🇸 US 🇨🇦 CA | Coolant Hose Heat Shield Included: YES | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85119158 | 🇺🇸 US 🇨🇦 CA | Auxiliary Radiator Outletwithout CLAMP | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12737234 | 🇺🇸 US 🇨🇦 CA | Thermostat Bypass | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056534 | 🇺🇸 US 🇨🇦 CA | Coolant Hose Heat Shield Included: YES | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85578389 | 🇺🇸 US 🇨🇦 CA | Fuel Cooler (Outlet) | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
GM GENUINE supplies the 6 Coolant Hose / Pipe parts for the 2021 GMC Sierra 2500. GM GENUINE 85119168 carries the "Popular" badge.
Part numbers include GM GENUINE 85119168, GM GENUINE 85056538 and GM GENUINE 85119158, among others listed above.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 12658352 | 🇺🇸 US 🇨🇦 CA | Material: RubberOutside Diameter (mm): 31.54 mm | View on Amazon |
| AJUSA Fits: 6.6L V8 DIESEL Turbocharged | 16097400 | 🇺🇸 US 🇨🇦 CA | COOLANT PIPE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12737097 | 🇺🇸 US 🇨🇦 CA | Material: Stainless Steel | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33755 | 🇺🇸 US 🇨🇦 CA | Steel | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33756 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
5 Coolant Hose / Pipe Seal parts for the 2021 GMC Sierra 2500 come from 3 brands — GM GENUINE, MAHLE / CLEVITE and AJUSA. The "Popular" part is GM GENUINE 12658352.
Listed part numbers: GM GENUINE 12658352, AJUSA 16097400 and GM GENUINE 12737097, plus the other parts above.
Coolant Hose Connector / Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 1510595 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Coolant Hose Connector flanges.
One part is listed for the 2021 GMC Sierra 2500 — GM GENUINE 1510595.
Coolant Hose Retainer / Clip
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 11547354 | 🇺🇸 US 🇨🇦 CA | OutletFITS 19-24.5MM TUBE | View on Amazon |
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 11547355 | 🇺🇸 US 🇨🇦 CA | OutletFITS 25-31MM TUBE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 11549297 | 🇺🇸 US 🇨🇦 CA | InletStrap-210 Long with Omega Clip For 10-14 Diameter | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11548857 | 🇺🇸 US 🇨🇦 CA | OutletTie Strap with Plastic Tree Fits 7.5-10.5MM Hole, 184MM Long | View on Amazon |
This table covers the Coolant Hose retainers and clips.
GM GENUINE supplies the 4 Coolant Hose Retainer / Clip parts for the 2021 GMC Sierra 2500. 2 parts fit every engine; the other 2 are engine-specific.
Listed part numbers: GM GENUINE 11547354, GM GENUINE 11547355 and GM GENUINE 11549297, plus the other parts above.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 | 603093 | 🇺🇸 US 🇨🇦 CA | Gas | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 84630072 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85639732 | 🇺🇸 US 🇨🇦 CA | Reservoir Material: Polypropylene (PP) | View on Amazon |
| TECHPRO Fits: 6.6L V8 | GM3014191 | 🇺🇸 US 🇨🇦 CA | GAS EngineHD Model | View on Amazon |
| TECHPRO Fits: 6.6L V8 | GM3014192 | 🇺🇸 US 🇨🇦 CA | Includes Cap | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
5 Coolant Reservoir parts for the 2021 GMC Sierra 2500 come from 3 brands — GM GENUINE, TECHPRO and DORMAN.
This group includes DORMAN 603093, GM GENUINE 84630072 and GM GENUINE 85639732 and the remaining parts above.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Popular Fits: all 2021 Sierra 2500 engines | 54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SKP Popular Fits: all 2021 Sierra 2500 engines | SK54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| AUTOTECNICA Fits: 6.6L V8 DIESEL Turbocharged | GM0714619 | 🇺🇸 US 🇨🇦 CA | Diameter: 45mmPressure Rating: 20psi | View on Amazon |
| CALORSTAT Fits: all 2021 Sierra 2500 engines | RC0144 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 20.0 PS | View on Amazon |
| GATES Fits: all 2021 Sierra 2500 engines | 31569 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Fits: all 2021 Sierra 2500 engines | T62 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | T130 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
7 Coolant Reservoir Cap parts for the 2021 GMC Sierra 2500 come from 6 brands — MOTORAD, DORMAN, SKP and 3 other brands. The "Popular" part is DORMAN 54218. 5 parts fit every engine; the other 2 are engine-specific.
Part numbers include DORMAN 54218, SKP SK54218 and AUTOTECNICA GM0714619, among others listed above.
Cooling System Tester Adapter
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: all 2021 Sierra 2500 engines | 3128 | 🇺🇸 US 🇨🇦 CA | StandardRadiator Cap Adapter | View on Amazon |
| MOTORAD Fits: all 2021 Sierra 2500 engines | 3127 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the adapters used to pressure-test this cooling system.
MOTORAD supplies both parts for the 2021 GMC Sierra 2500. All of them fit every engine offered in the 2021 Sierra 2500.
This group includes MOTORAD 3128 and MOTORAD 3127.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 11570871 | 🇺🇸 US 🇨🇦 CA | Gray | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 11547681 | 🇺🇸 US 🇨🇦 CA | UpperM37X15 | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 11548976 | 🇺🇸 US 🇨🇦 CA | Lower48 Diameter | View on Amazon |
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 90530642 | 🇺🇸 US 🇨🇦 CA | Fits Clamp-Sprindband, 14X12, Double BandAir Bleed Hos | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549085 | 🇺🇸 US 🇨🇦 CA | Fits Clamp, Springband, 13MM Diameter X 12 WideAir Bleed Hose | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549298 | 🇺🇸 US 🇨🇦 CA | Fits Lower32.0 X 12.0 | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11548772 | 🇺🇸 US 🇨🇦 CA | LowerClamp, Springband, Normally Closed | View on Amazon |
This table covers the Hose clamps.
GM GENUINE supplies the 7 Hose Clamp parts for the 2021 GMC Sierra 2500. GM GENUINE 11570871 carries the "Popular" badge. 1 part fits every engine; the other 6 are engine-specific.
Listed part numbers: GM GENUINE 11570871, GM GENUINE 11547681 and GM GENUINE 11548976, plus the other parts above.
Intercooler
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TECHPRO Fits: 6.6L V8 DIESEL Turbocharged | GM3012129 | 🇺🇸 US 🇨🇦 CA | HD Model | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 84747171 | 🇺🇸 US 🇨🇦 CA | Mounting Hardware Included: YES | View on Amazon |
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TYC Fits: 6.6L V8 DIESEL Turbocharged | 18145 | 🇺🇸 US 🇨🇦 CA | DIESEL | View on Amazon |
| VARIOUS MFR Fits: 6.6L V8 DIESEL Turbocharged | GM3012129 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the intercoolers that cool turbo or supercharger charge air.
4 Intercooler parts are listed for the 2021 GMC Sierra 2500, from TECHPRO, GM GENUINE, TYC and 1 other brand.
Economy: 1 part, from TECHPRO. A representative part number is TECHPRO GM3012129.
The Standard Replacement section: 1 option from GM GENUINE. GM GENUINE 84747171 is listed in this group.
2 ungrouped parts are not assigned to a grade, with the same engine-level match.
This group includes TECHPRO GM3012129, GM GENUINE 84747171 and TYC 18145 and the remaining parts above.
Intercooler Air Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 DIESEL Turbocharged | 667828 | 🇺🇸 US 🇨🇦 CA | Turbocharger To Intercooler (Hot Side) | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 84870726 | 🇺🇸 US 🇨🇦 CA | End 1 Inside Diameter (In): 3.08 In | View on Amazon |
| SKP Fits: 6.6L V8 DIESEL Turbocharged | SK84870726 | 🇺🇸 US 🇨🇦 CA | Air Inlet | View on Amazon |
This table covers the Intercooler Air Hose pipes.
3 Intercooler Air Hose / Pipe parts are listed for the 2021 GMC Sierra 2500, from DORMAN, GM GENUINE and SKP.
Part numbers include DORMAN 667828, GM GENUINE 84870726 and SKP SK84870726.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Popular Fits: 6.6L V8 | 13885C | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.6L V8 DIESEL Turbocharged | 13893C | 🇺🇸 US 🇨🇦 CA | Auxiliary | View on Amazon |
| GPD Fits: 6.6L V8 DIESEL Turbocharged | 13879C | 🇺🇸 US 🇨🇦 CA | PRIMARY | View on Amazon |
| TECHPRO Fits: 6.6L V8 | GM3010625 | 🇺🇸 US 🇨🇦 CA | Gas | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Popular Fits: 6.6L V8 DIESEL Turbocharged | 3938 | 🇺🇸 US 🇨🇦 CA | Auxiliary Radiator | View on Amazon |
| CSF Popular Fits: 6.6L V8 DIESEL Turbocharged | 3928 | 🇺🇸 US 🇨🇦 CA | with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings. | View on Amazon |
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 84799449 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 21978 | 🇺🇸 US 🇨🇦 CA | Aluminum Core / Aluminum Tank | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85610318 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| KOYORAD Fits: all 2021 Sierra 2500 engines | A13879 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SPECTRA PREMIUM Fits: 6.6L V8 | CU13885 | 🇺🇸 US 🇨🇦 CA | Gas | View on Amazon |
| SPECTRA PREMIUM Fits: 6.6L V8 DIESEL Turbocharged | CU13879 | 🇺🇸 US 🇨🇦 CA | Main Unit | View on Amazon |
| TYC Fits: 6.6L V8 DIESEL Turbocharged | 13879 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UAC Fits: 6.6L V8 | RA13885C | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
14 Radiator parts are listed for the 2021 GMC Sierra 2500, from GPD, CSF, GM GENUINE and 6 other brands. GPD 13885C carries the "Popular" badge. 1 part fits every engine; the other 13 are engine-specific.
Economy: 4 parts, from GPD and TECHPRO. A representative part number is GPD 13885C.
The Standard Replacement section: 10 options from CSF, GM GENUINE, SPECTRA PREMIUM and 4 other brands. CSF 3938 is listed in this group.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: all 2021 Sierra 2500 engines | RC124 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| PROFESSIONAL PARTS SWEDEN Fits: all 2021 Sierra 2500 engines | 21342353 | 🇺🇸 US 🇨🇦 CA | Gas | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
2 Radiator Cap parts are listed for the 2021 GMC Sierra 2500, from ACDELCO and PROFESSIONAL PARTS SWEDEN. All of them fit every engine offered in the 2021 Sierra 2500.
Listed part numbers: ACDELCO RC124 and PROFESSIONAL PARTS SWEDEN 21342353.
Radiator Drain Petcock
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 22790134 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the petcocks used to drain the radiator.
This group shows a single part: GM GENUINE 22790134.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 | 621111 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 | 1581671 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 1582003 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.6L V8 | 2812331 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
4 Radiator Fan Blade parts for the 2021 GMC Sierra 2500 come from 3 brands — GM GENUINE, DORMAN and GPD.
Listed part numbers: DORMAN 621111, GM GENUINE 1581671 and GM GENUINE 1582003, plus the other parts above.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 6.6L V8 | 46145 | 🇺🇸 US 🇨🇦 CA | Severe Duty Thermal | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 1540608 | 🇺🇸 US 🇨🇦 CA | Thermal | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85824793 | 🇺🇸 US 🇨🇦 CA | 4WD | View on Amazon |
| HAYDEN Fits: 6.6L V8 | 2984 | 🇺🇸 US 🇨🇦 CA | ThermalSevere Duty | View on Amazon |
| US MOTOR WORKS Fits: 6.6L V8 | 22639 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
5 Radiator Fan Clutch parts are listed for the 2021 GMC Sierra 2500, from GM GENUINE, FOUR SEASONS, HAYDEN and 1 other brand.
Part numbers include FOUR SEASONS 46145, GM GENUINE 1540608 and GM GENUINE 85824793, among others listed above.
Radiator Fan Motor Bracket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 84182182 | 🇺🇸 US 🇨🇦 CA | Upper | View on Amazon |
This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.
One part is listed for the 2021 GMC Sierra 2500 — GM GENUINE 84182182.
Radiator Fan Pulley
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12714130 | 🇺🇸 US 🇨🇦 CA | Only For 4WD Applications | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12714129 | 🇺🇸 US 🇨🇦 CA | Only For 2WD Applications.28" Fan | View on Amazon |
This table covers the Radiator Fan pulleys. Typical signs include a growl or chirp that follows engine speed, or a pulley that will not spin freely by hand. Spin each pulley with the belt off. Roughness or play means replace it with the belt.
GM GENUINE supplies both parts for the 2021 GMC Sierra 2500.
Part numbers include GM GENUINE 12714130 and GM GENUINE 12714129.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 85112067 | 🇺🇸 US 🇨🇦 CA | Rearward | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 87868034 | 🇺🇸 US 🇨🇦 CA | Rearward | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
GM GENUINE supplies both parts for the 2021 GMC Sierra 2500.
Part numbers include GM GENUINE 85112067 and GM GENUINE 87868034.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 | 85119159 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| ACDELCO Fits: 6.6L V8 | 85119166 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 85122989 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Fits: 6.6L V8 | 52450 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056546 | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
5 Radiator Hose parts for the 2021 GMC Sierra 2500 come from 3 brands — ACDELCO, GATES and GM GENUINE.
Part numbers include ACDELCO 85119159, ACDELCO 85119166 and ACDELCO 85122989, among others listed above.
Radiator Overflow Tube Repair Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 | 22799347 | 🇺🇸 US 🇨🇦 CA | Surge Tank Hose Protector | View on Amazon |
This table covers the Radiator Overflow Tube repair kits.
This group shows a single part: GM GENUINE 22799347.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ULTRA-POWER Popular Fits: 6.6L V8 DIESEL Turbocharged | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: all 2021 Sierra 2500 engines | 1712496 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: all 2021 Sierra 2500 engines | 2CTS0184 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| STANDARD MOTOR PRODUCTS Popular Fits: all 2021 Sierra 2500 engines | TX247 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| WALKER PRODUCTS Popular Fits: all 2021 Sierra 2500 engines | 2112015 | 🇺🇸 US 🇨🇦 CA | SensorIncludes O-Ring | View on Amazon |
| FACET Fits: all 2021 Sierra 2500 engines | 73379 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Oblong | View on Amazon |
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 25186240 | 🇺🇸 US 🇨🇦 CA | Mating Connector Use 13587326 | View on Amazon |
| WELLS Fits: all 2021 Sierra 2500 engines | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
8 Temperature Sender / Sensor parts are listed for the 2021 GMC Sierra 2500, from ULTRA-POWER, GPD, HOLSTEIN and 5 other brands. ULTRA-POWER 5S13427 carries the "Popular" badge. 7 parts fit every engine; the other 1 is engine-specific.
Economy: 3 parts, from ULTRA-POWER, GPD and HOLSTEIN. A representative part number is ULTRA-POWER 5S13427.
The Standard Replacement section: 5 options from STANDARD MOTOR PRODUCTS, WALKER PRODUCTS, FACET and 2 other brands. STANDARD MOTOR PRODUCTS TX247 is listed in this group.
Listed part numbers: ULTRA-POWER 5S13427, GPD 1712496 and HOLSTEIN 2CTS0184, plus the other parts above.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AUTOTECNICA Fits: 6.6L V8 | GM0718523 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| DORMAN Fits: 6.6L V8 | 9022981 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| SKP Fits: all 2021 Sierra 2500 engines | SK131160 | 🇺🇸 US 🇨🇦 CA | 190 Degree | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.6L V8 | 5523187 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 5523160 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.6L V8 | 2523160 | 🇺🇸 US 🇨🇦 CA | High FlowIncludes seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | MRD105 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 6.6L V8 | 131160 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Popular Fits: 6.6L V8 | 34198 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 | 523190 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 | 523160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged | 447185 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged | 447448 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| AISIN Fits: 6.6L V8 | THRGM0002 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat SealWithout Integrated Housing | View on Amazon |
| CALORSTAT Fits: 6.6L V8 | TH210786J | 🇺🇸 US 🇨🇦 CA | Includes 1 Rubber Gasket | View on Amazon |
| CALORSTAT Fits: 6.6L V8 | TH210782J | 🇺🇸 US 🇨🇦 CA | PerformanceIncludes 1 Rubber Gasket | View on Amazon |
| CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged | TH152983J | 🇺🇸 US 🇨🇦 CA | Includes 1 Paper Gasket | View on Amazon |
| CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged | THK750582J | 🇺🇸 US 🇨🇦 CA | KitIncludes 1 Rubber Gasket | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 19420815 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 131197 | 🇺🇸 US 🇨🇦 CA | GM Original EquipmentDoes Not Include O-Ring | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 131198 | 🇺🇸 US 🇨🇦 CA | Single UseRR | View on Amazon |
| MAHLE / CLEVITE Fits: all 2021 Sierra 2500 engines | TX49971D | 🇺🇸 US 🇨🇦 CA | Opening Temperature 71with Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | TX50282D | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 523174 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 523180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 6.6L V8 | 5945KT | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and HousingKit | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | 448180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
27 Thermostat parts for the 2021 GMC Sierra 2500 come from 10 brands — MOTORAD, CALORSTAT, GM GENUINE and 7 other brands. The "Popular" part is ACDELCO 131160. Grades run from Economy through Standard Replacement; Standard Replacement is the most populated section, led by MOTORAD, CALORSTAT, GM GENUINE and 4 other brands.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.6L V8 | 36219 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12643149 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 94034146 | 🇺🇸 US 🇨🇦 CA | Single UseInside Diameter: 10.2 Outside Diameter: 15.2 | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12680544 | 🇺🇸 US 🇨🇦 CA | Single UseThermostat Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33723 | 🇺🇸 US 🇨🇦 CA | Beaded Steel | View on Amazon |
| VICTOR REINZ Fits: 6.6L V8 | 711357800 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
6 Thermostat / Thermostat Housing / Water Outlet Seal parts are listed for the 2021 GMC Sierra 2500, from GM GENUINE, FEL-PRO, MAHLE / CLEVITE and 1 other brand.
This group includes FEL-PRO 36219, GM GENUINE 12643149 and GM GENUINE 94034146 and the remaining parts above.
Thermostat Housing / Water Outlet
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 | 9022081 | 🇺🇸 US 🇨🇦 CA | Water PumpThermostat Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 6.6L V8 | 85945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| MOTORAD Fits: 6.6L V8 | CH5945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Popular Fits: 6.6L V8 DIESEL Turbocharged | 85945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12706111 | 🇺🇸 US 🇨🇦 CA | Gasket/Seal Not Included | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12743523 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | CH3152 | 🇺🇸 US 🇨🇦 CA | Fits UpperWater Outlet | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | CH1072 | 🇺🇸 US 🇨🇦 CA | Fits LowerThermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
8 Thermostat Housing / Water Outlet parts for the 2021 GMC Sierra 2500 come from 4 brands — MOTORAD, FOUR SEASONS, GM GENUINE and 1 other brand. The "Popular" part is FOUR SEASONS 85945.
The Economy section: 1 option from DORMAN. DORMAN 9022081 is listed in this group.
Standard Replacement: 2 parts, from FOUR SEASONS and MOTORAD. A representative part number is FOUR SEASONS 85945.
5 further parts sit outside the graded sections, with the same engine-level match.
Part numbers include FOUR SEASONS 85945, DORMAN 9022081 and MOTORAD CH5945, among others listed above.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 12587397 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2021 GMC Sierra 2500 — GM GENUINE 12587397.
Water Pump
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 251817 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 2521039 | 🇺🇸 US 🇨🇦 CA | GoldDoes Not Include Mount Bolts | View on Amazon |
| FVP Fits: 6.6L V8 | 1303210 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GATES Fits: 6.6L V8 DIESEL Turbocharged | 42229 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 6.6L V8 | 12735409 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat | View on Amazon |
| GMB Fits: 6.6L V8 | 1303210 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 6.6L V8 DIESEL Turbocharged | 1304030 | 🇺🇸 US 🇨🇦 CA | PUMP without HOUSING | View on Amazon |
| GMB Fits: 6.6L V8 DIESEL Turbocharged | 1304030AH | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
8 Water Pump parts for the 2021 GMC Sierra 2500 come from 5 brands — GMB, GM GENUINE, ACDELCO and 2 other brands. The "Popular" part is GM GENUINE 251817.
This group includes GM GENUINE 251817, ACDELCO 2521039 and FVP 1303210 and the remaining parts above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.6L V8 | 36110 | 🇺🇸 US 🇨🇦 CA | To BlockHousing To Block | View on Amazon |
| FEL-PRO Fits: 6.6L V8 | 36109 | 🇺🇸 US 🇨🇦 CA | To BlockPump To Housing | View on Amazon |
| GM GENUINE Fits: 6.6L V8 | 2512073 | 🇺🇸 US 🇨🇦 CA | 6 speed Automatic trans. | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 | K33358 | 🇺🇸 US 🇨🇦 CA | SteelIncludes 2 Gaskets | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | GS34037 | 🇺🇸 US 🇨🇦 CA | Contains All Gaskets Required For Water Pump Installation | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
5 Water Pump Gasket parts are listed for the 2021 GMC Sierra 2500, from FEL-PRO, MAHLE / CLEVITE and GM GENUINE.
Part numbers include FEL-PRO 36110, FEL-PRO 36109 and GM GENUINE 2512073, among others listed above.
Water Pump Inlet Tube
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Fits: 6.6L V8 DIESEL Turbocharged | HHA161 | 🇺🇸 US 🇨🇦 CA | Pipe | View on Amazon |
This table covers the Water Pump Inlet tubes.
This group shows a single part: GATES HHA161.
Water Pump Seal / O-Ring
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2021 Sierra 2500 engines | 2512031 | 🇺🇸 US 🇨🇦 CA | (OEM Design) | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12643779 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
This table covers the Water Pump Seal O-rings. Typical signs include a seep at a fitting or a housing that weeps after a service. Lube the new O-ring with the fluid it will see, and do not roll it into the groove.
2 Water Pump Seal / O-Ring parts for the 2021 GMC Sierra 2500 come from GM GENUINE. 1 part fits every engine; the other 1 is engine-specific.
Part numbers include GM GENUINE 2512031 and GM GENUINE 12643779.
Buying Cooling System Parts for a 2021 GMC Sierra 2500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Thermostat and Coolant / Antifreeze .
Frequently Asked Questions
How many cooling system parts fit the 2021 GMC Sierra 2500?
Our catalog currently lists 167 cooling system parts for the 2021 GMC Sierra 2500 across 31 subcategories and 36 brands, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 GMC Sierra 2500 engines?
Some do. 38 parts fit every engine; the other 129 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 GMC Sierra 2500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 GMC Sierra 2500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 GMC Sierra 2500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 GMC Sierra 2500
Cooling System Parts for Other GMC Sierra 2500 Years
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