2021 GMC Sierra 2500 Cooling System Parts

Engine:

Showing parts for every engine. Select an engine to see only what fits.

This page lists 167 cooling system parts for the 2021 GMC Sierra 2500, across 31 part types, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Every part shows its brand, manufacturer part number and fitment notes.

The cooling system system on the 2021 GMC Sierra 2500 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Thermostat (27 parts), Coolant / Antifreeze (17 parts) and Radiator (14 parts). The other 28 part types cover the remaining 109 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE Fits: 6.6L V8 DIESEL Turbocharged AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
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Economy

Brand Part Number Markets Notes Buy
FVP Popular Fits: all 2021 Sierra 2500 engines MV5050GAL
🇺🇸 US 🇨🇦 CA
Extended LifeAll Makes / All Models
Fitment notes — FVP MV5050GAL
Extended LifeAll Makes / All Models1 Gallon
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PEAK Fits: all 2021 Sierra 2500 engines BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
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PRESTONE Fits: 6.6L V8 DIESEL Turbocharged AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
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VALVOLINE Fits: all 2021 Sierra 2500 engines 719009
🇺🇸 US 🇨🇦 CA
Multi-Vehicle Yellow1 Gallon
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Heavy Duty

Brand Part Number Markets Notes Buy
PRESTONE Fits: all 2021 Sierra 2500 engines AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
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Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular Fits: 6.6L V8 DIESEL Turbocharged AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
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PEAK Fits: all 2021 Sierra 2500 engines PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
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PEAK Fits: all 2021 Sierra 2500 engines PXA1GAL
🇺🇸 US 🇨🇦 CA
1 GallonGlobal Lifetime
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PRESTONE Fits: 6.6L V8 DIESEL Turbocharged AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
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Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular Fits: all 2021 Sierra 2500 engines 105027
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon
Fitment notes — ACDELCO 105027
DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 GallonPremix1 Gallon GM Original EquipmentOrange
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VALVOLINE Popular Fits: all 2021 Sierra 2500 engines ZXEL1
🇺🇸 US 🇨🇦 CA
Dex-Cool Orange1 Gallon
Fitment notes — VALVOLINE ZXEL1
Dex-Cool Orange1 GallonOAT
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AISIN Fits: all 2021 Sierra 2500 engines ACD005
🇺🇸 US 🇨🇦 CA
OrangeOAT
Fitment notes — AISIN ACD005
OrangeOAT
(Type: Prediluted)
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FVP Fits: all 2021 Sierra 2500 engines DEX5050GAL
🇺🇸 US 🇨🇦 CA
Extended Life Blend1 Gallon
Fitment notes — FVP DEX5050GAL
Extended Life Blend1 GallonOrangeOAT
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PRESTONE Fits: all 2021 Sierra 2500 engines AF3400
🇺🇸 US 🇨🇦 CA
Prime OrangeOrange Compatible
Fitment notes — PRESTONE AF3400
Prime OrangeOrange CompatibleExtended Life1 Gallon ConcentrateOAT
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PRESTONE Fits: all 2021 Sierra 2500 engines AF850
🇺🇸 US 🇨🇦 CA
DEX-Cool Extended Life1 Gallon
Fitment notes — PRESTONE AF850
DEX-Cool Extended Life1 GallonOrangeOAT
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VALVOLINE Fits: all 2021 Sierra 2500 engines 888374
🇺🇸 US 🇨🇦 CA
American Vehicle Orange1 Gallon
Fitment notes — VALVOLINE 888374
American Vehicle Orange1 Gallon
(Type: Prediluted)
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This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Air Bleed Hose / Pipe

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 85056536
🇺🇸 US 🇨🇦 CA
Shape: Molded Assembly
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 11549085
🇺🇸 US 🇨🇦 CA
CLAMP, SPRINGBAND, 13MM DIAMETER X 12 WIDE
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85056532
🇺🇸 US 🇨🇦 CA
Shape: Molded Assembly
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This table covers the Coolant Air Bleed Hose pipes.

Coolant Hose / Pipe

Brand Part Number Markets Notes Buy
GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged 85119168
🇺🇸 US 🇨🇦 CA
Expansion Tank Outlet
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GM GENUINE Fits: 6.6L V8 85056538
🇺🇸 US 🇨🇦 CA
Coolant Hose Heat Shield Included: YES
Fitment notes — GM GENUINE 85056538
Coolant Hose Heat Shield Included: YES
Expansion Tank Inlet
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85119158
🇺🇸 US 🇨🇦 CA
Auxiliary Radiator Outletwithout CLAMP
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12737234
🇺🇸 US 🇨🇦 CA
Thermostat Bypass
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85056534
🇺🇸 US 🇨🇦 CA
Coolant Hose Heat Shield Included: YES
Fitment notes — GM GENUINE 85056534
Coolant Hose Heat Shield Included: YES
Expansion Tank Inlet
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85578389
🇺🇸 US 🇨🇦 CA
Fuel Cooler (Outlet)
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This table covers the hard pipes and extra hoses in the coolant circuit.

Coolant Hose / Pipe Seal

Brand Part Number Markets Notes Buy
GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged 12658352
🇺🇸 US 🇨🇦 CA
Material: RubberOutside Diameter (mm): 31.54 mm
Fitment notes — GM GENUINE 12658352
Material: RubberOutside Diameter (mm): 31.54 mm
Single UseThermostat Bypass Pipe Seal
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AJUSA Fits: 6.6L V8 DIESEL Turbocharged 16097400
🇺🇸 US 🇨🇦 CA
COOLANT PIPE
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12737097
🇺🇸 US 🇨🇦 CA
Material: Stainless Steel
Fitment notes — GM GENUINE 12737097
Material: Stainless Steel
Single UseThermostat Bypass Pipe Seal
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MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged C33755
🇺🇸 US 🇨🇦 CA
Steel
Fitment notes — MAHLE / CLEVITE C33755
Steel
Water Bypass Seal
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MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged C33756
🇺🇸 US 🇨🇦 CA
Engine Coolant Outlet O-RingMolded Rubber
Fitment notes — MAHLE / CLEVITE C33756
Engine Coolant Outlet O-RingMolded Rubber
COOLANT PIPE
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This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Coolant Hose Connector / Flange

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 1510595
🇺🇸 US 🇨🇦 CA
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This table covers the Coolant Hose Connector flanges.

Coolant Hose Retainer / Clip

Brand Part Number Markets Notes Buy
GM GENUINE Fits: all 2021 Sierra 2500 engines 11547354
🇺🇸 US 🇨🇦 CA
OutletFITS 19-24.5MM TUBE
Fitment notes — GM GENUINE 11547354
OutletFITS 19-24.5MM TUBECLIP with Tie Strap
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GM GENUINE Fits: all 2021 Sierra 2500 engines 11547355
🇺🇸 US 🇨🇦 CA
OutletFITS 25-31MM TUBE
Fitment notes — GM GENUINE 11547355
OutletFITS 25-31MM TUBECLIP with Tie Strap
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GM GENUINE Fits: 6.6L V8 11549297
🇺🇸 US 🇨🇦 CA
InletStrap-210 Long with Omega Clip For 10-14 Diameter
Fitment notes — GM GENUINE 11549297
InletStrap-210 Long with Omega Clip For 10-14 DiameterDiameter 15.0 X 4.7 X 210
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 11548857
🇺🇸 US 🇨🇦 CA
OutletTie Strap with Plastic Tree Fits 7.5-10.5MM Hole, 184MM Long
Fitment notes — GM GENUINE 11548857
OutletTie Strap with Plastic Tree Fits 7.5-10.5MM Hole, 184MM LongClip with Tie Strap, Fits 9.3-10.7MM Threaded HoleReservoir Hose
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This table covers the Coolant Hose retainers and clips.

Coolant Reservoir

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.6L V8 603093
🇺🇸 US 🇨🇦 CA
Gas
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GM GENUINE Fits: 6.6L V8 84630072
🇺🇸 US 🇨🇦 CA
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85639732
🇺🇸 US 🇨🇦 CA
Reservoir Material: Polypropylene (PP)
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TECHPRO Fits: 6.6L V8 GM3014191
🇺🇸 US 🇨🇦 CA
GAS EngineHD Model
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TECHPRO Fits: 6.6L V8 GM3014192
🇺🇸 US 🇨🇦 CA
Includes Cap
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This table covers the overflow / expansion tanks that hold extra coolant.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
DORMAN Popular Fits: all 2021 Sierra 2500 engines 54218
🇺🇸 US 🇨🇦 CA
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SKP Popular Fits: all 2021 Sierra 2500 engines SK54218
🇺🇸 US 🇨🇦 CA
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AUTOTECNICA Fits: 6.6L V8 DIESEL Turbocharged GM0714619
🇺🇸 US 🇨🇦 CA
Diameter: 45mmPressure Rating: 20psi
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CALORSTAT Fits: all 2021 Sierra 2500 engines RC0144
🇺🇸 US 🇨🇦 CA
Maximum Pressure Rating: 20.0 PS
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GATES Fits: all 2021 Sierra 2500 engines 31569
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 31569
OE Type
20 psi Pressure Rating
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MOTORAD Fits: all 2021 Sierra 2500 engines T62
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T62
Standard
Relief Pressure 20 lbs
PrimaryRelief Pressure 20 lbs
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MOTORAD Fits: 6.6L V8 DIESEL Turbocharged T130
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T130
Standard
AuxiliaryRelief Pressure 5 lbs
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This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Cooling System Tester Adapter

Brand Part Number Markets Notes Buy
MOTORAD Fits: all 2021 Sierra 2500 engines 3128
🇺🇸 US 🇨🇦 CA
StandardRadiator Cap Adapter
Fitment notes — MOTORAD 3128
StandardRadiator Cap Adapter
Cooling System PressureRadiator Cap Adapter
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MOTORAD Fits: all 2021 Sierra 2500 engines 3127
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD 3127
Standard
Cooling System Pressure
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This table covers the adapters used to pressure-test this cooling system.

Hose Clamp

Brand Part Number Markets Notes Buy
GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged 11570871
🇺🇸 US 🇨🇦 CA
Gray
Fitment notes — GM GENUINE 11570871
Gray
Fits:
LowerM23X12Radiator Hose
or:
UpperM23X12Radiator Hose
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GM GENUINE Fits: 6.6L V8 11547681
🇺🇸 US 🇨🇦 CA
UpperM37X15
Fitment notes — GM GENUINE 11547681
UpperM37X15Radiator Hose
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GM GENUINE Fits: 6.6L V8 11548976
🇺🇸 US 🇨🇦 CA
Lower48 Diameter
Fitment notes — GM GENUINE 11548976
Lower48 DiameterRadiator Hose
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GM GENUINE Fits: all 2021 Sierra 2500 engines 90530642
🇺🇸 US 🇨🇦 CA
Fits Clamp-Sprindband, 14X12, Double BandAir Bleed Hos
Fitment notes — GM GENUINE 90530642
Fits:
Clamp-Sprindband, 14X12, Double BandAir Bleed Hos
or:
Clamp-Sprindband, 14X12, Double BandReservoir Inlet Hose
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 11549085
🇺🇸 US 🇨🇦 CA
Fits Clamp, Springband, 13MM Diameter X 12 WideAir Bleed Hose
Fitment notes — GM GENUINE 11549085
Fits:
Clamp, Springband, 13MM Diameter X 12 WideAir Bleed Hose
or:
LowerClamp, Springband, 13MM Diameter X 12 WideRadiator Hose
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 11549298
🇺🇸 US 🇨🇦 CA
Fits Lower32.0 X 12.0
Fitment notes — GM GENUINE 11549298
Fits:
Lower32.0 X 12.0Low ProfileRadiator Hos
or:
32.0 X 12.0Low ProfileReservoir Outlet Hose
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 11548772
🇺🇸 US 🇨🇦 CA
LowerClamp, Springband, Normally Closed
Fitment notes — GM GENUINE 11548772
LowerClamp, Springband, Normally Closed53X15Radiator Hose
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This table covers the Hose clamps.

Intercooler

Economy

Brand Part Number Markets Notes Buy
TECHPRO Fits: 6.6L V8 DIESEL Turbocharged GM3012129
🇺🇸 US 🇨🇦 CA
HD Model
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Standard Replacement

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 84747171
🇺🇸 US 🇨🇦 CA
Mounting Hardware Included: YES
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Brand Part Number Markets Notes Buy
TYC Fits: 6.6L V8 DIESEL Turbocharged 18145
🇺🇸 US 🇨🇦 CA
DIESEL
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VARIOUS MFR Fits: 6.6L V8 DIESEL Turbocharged GM3012129
🇺🇸 US 🇨🇦 CA
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This table covers the intercoolers that cool turbo or supercharger charge air.

Intercooler Air Hose / Pipe

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.6L V8 DIESEL Turbocharged 667828
🇺🇸 US 🇨🇦 CA
Turbocharger To Intercooler (Hot Side)
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 84870726
🇺🇸 US 🇨🇦 CA
End 1 Inside Diameter (In): 3.08 In
Fitment notes — GM GENUINE 84870726
End 1 Inside Diameter (In): 3.08 In
Air Inlet
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SKP Fits: 6.6L V8 DIESEL Turbocharged SK84870726
🇺🇸 US 🇨🇦 CA
Air Inlet
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This table covers the Intercooler Air Hose pipes.

Radiator

Economy

Brand Part Number Markets Notes Buy
GPD Popular Fits: 6.6L V8 13885C
🇺🇸 US 🇨🇦 CA
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GPD Fits: 6.6L V8 DIESEL Turbocharged 13893C
🇺🇸 US 🇨🇦 CA
Auxiliary
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GPD Fits: 6.6L V8 DIESEL Turbocharged 13879C
🇺🇸 US 🇨🇦 CA
PRIMARY
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TECHPRO Fits: 6.6L V8 GM3010625
🇺🇸 US 🇨🇦 CA
Gas
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Standard Replacement

Brand Part Number Markets Notes Buy
CSF Popular Fits: 6.6L V8 DIESEL Turbocharged 3938
🇺🇸 US 🇨🇦 CA
Auxiliary Radiator
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CSF Popular Fits: 6.6L V8 DIESEL Turbocharged 3928
🇺🇸 US 🇨🇦 CA
with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings.
Fitment notes — CSF 3928
with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings.
Standard Radiator
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ACDELCO Fits: 6.6L V8 DIESEL Turbocharged 84799449
🇺🇸 US 🇨🇦 CA
GM Original Equipment
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 21978
🇺🇸 US 🇨🇦 CA
Aluminum Core / Aluminum Tank
Fitment notes — GM GENUINE 21978
Aluminum Core / Aluminum Tank
Auxiliary
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85610318
🇺🇸 US 🇨🇦 CA
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KOYORAD Fits: all 2021 Sierra 2500 engines A13879
🇺🇸 US 🇨🇦 CA
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SPECTRA PREMIUM Fits: 6.6L V8 CU13885
🇺🇸 US 🇨🇦 CA
Gas
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SPECTRA PREMIUM Fits: 6.6L V8 DIESEL Turbocharged CU13879
🇺🇸 US 🇨🇦 CA
Main Unit
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TYC Fits: 6.6L V8 DIESEL Turbocharged 13879
🇺🇸 US 🇨🇦 CA
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UAC Fits: 6.6L V8 RA13885C
🇺🇸 US 🇨🇦 CA
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This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Brand Part Number Markets Notes Buy
ACDELCO Fits: all 2021 Sierra 2500 engines RC124
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO RC124
GM Original Equipment
SIDE CAP
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PROFESSIONAL PARTS SWEDEN Fits: all 2021 Sierra 2500 engines 21342353
🇺🇸 US 🇨🇦 CA
Gas
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This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Drain Petcock

Brand Part Number Markets Notes Buy
GM GENUINE Fits: all 2021 Sierra 2500 engines 22790134
🇺🇸 US 🇨🇦 CA
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This table covers the petcocks used to drain the radiator.

Radiator Fan Blade

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.6L V8 621111
🇺🇸 US 🇨🇦 CA
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GM GENUINE Fits: 6.6L V8 1581671
🇺🇸 US 🇨🇦 CA
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 1582003
🇺🇸 US 🇨🇦 CA
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GPD Fits: 6.6L V8 2812331
🇺🇸 US 🇨🇦 CA
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This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
FOUR SEASONS Fits: 6.6L V8 46145
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — FOUR SEASONS 46145
Severe Duty Thermal
GASCounter Clockwise
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GM GENUINE Fits: 6.6L V8 1540608
🇺🇸 US 🇨🇦 CA
Thermal
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85824793
🇺🇸 US 🇨🇦 CA
4WD
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HAYDEN Fits: 6.6L V8 2984
🇺🇸 US 🇨🇦 CA
ThermalSevere Duty
Fitment notes — HAYDEN 2984
ThermalSevere Duty
GASCounter Clockwise
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US MOTOR WORKS Fits: 6.6L V8 22639
🇺🇸 US 🇨🇦 CA
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This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Fan Motor Bracket

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 84182182
🇺🇸 US 🇨🇦 CA
Upper
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This table covers the brackets that mount the Radiator Fan Motor. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.

Radiator Fan Pulley

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12714130
🇺🇸 US 🇨🇦 CA
Only For 4WD Applications
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12714129
🇺🇸 US 🇨🇦 CA
Only For 2WD Applications.28" Fan
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This table covers the Radiator Fan pulleys. Typical signs include a growl or chirp that follows engine speed, or a pulley that will not spin freely by hand. Spin each pulley with the belt off. Roughness or play means replace it with the belt.

Radiator Fan Shroud

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 85112067
🇺🇸 US 🇨🇦 CA
Rearward
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 87868034
🇺🇸 US 🇨🇦 CA
Rearward
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This table covers the shrouds that duct air through the fan and radiator.

Radiator Hose

Brand Part Number Markets Notes Buy
ACDELCO Fits: 6.6L V8 85119159
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 85119159
GM Original Equipment
Lower
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ACDELCO Fits: 6.6L V8 85119166
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 85119166
GM Original Equipment
Upper
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ACDELCO Fits: 6.6L V8 DIESEL Turbocharged 85122989
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 85122989
GM Original Equipment
UpperSERVICE HOSE without POPP CLAMP
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GATES Fits: 6.6L V8 52450
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 52450
Molded
Upper
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 85056546
🇺🇸 US 🇨🇦 CA
Lower
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This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Radiator Overflow Tube Repair Kit

Brand Part Number Markets Notes Buy
GM GENUINE Fits: 6.6L V8 22799347
🇺🇸 US 🇨🇦 CA
Surge Tank Hose Protector
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This table covers the Radiator Overflow Tube repair kits.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
ULTRA-POWER Popular Fits: 6.6L V8 DIESEL Turbocharged 5S13427
🇺🇸 US 🇨🇦 CA
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GPD Fits: all 2021 Sierra 2500 engines 1712496
🇺🇸 US 🇨🇦 CA
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HOLSTEIN Fits: all 2021 Sierra 2500 engines 2CTS0184
🇺🇸 US 🇨🇦 CA
View on
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Standard Replacement

Brand Part Number Markets Notes Buy
STANDARD MOTOR PRODUCTS Popular Fits: all 2021 Sierra 2500 engines TX247
🇺🇸 US 🇨🇦 CA
View on
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WALKER PRODUCTS Popular Fits: all 2021 Sierra 2500 engines 2112015
🇺🇸 US 🇨🇦 CA
SensorIncludes O-Ring
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FACET Fits: all 2021 Sierra 2500 engines 73379
🇺🇸 US 🇨🇦 CA
Connector Shape: Oblong
Fitment notes — FACET 73379
Connector Shape: Oblong
Gas
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GM GENUINE Fits: all 2021 Sierra 2500 engines 25186240
🇺🇸 US 🇨🇦 CA
Mating Connector Use 13587326
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WELLS Fits: all 2021 Sierra 2500 engines 5S13427
🇺🇸 US 🇨🇦 CA
View on
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This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
AUTOTECNICA Fits: 6.6L V8 GM0718523
🇺🇸 US 🇨🇦 CA
Includes Housing
Fitment notes — AUTOTECNICA GM0718523
Includes Housing
GasSealing Flange Outside Diameter: 72mm
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DORMAN Fits: 6.6L V8 9022981
🇺🇸 US 🇨🇦 CA
Includes Housing
Fitment notes — DORMAN 9022981
Includes Housing
Water Pump
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SKP Fits: all 2021 Sierra 2500 engines SK131160
🇺🇸 US 🇨🇦 CA
190 Degree
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Heavy Duty

Brand Part Number Markets Notes Buy
MOTORAD Fits: 6.6L V8 5523187
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523187
Ultra StatIncludes seal
187 Degrees FOE Specified Temperature
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MOTORAD Fits: 6.6L V8 5523160
🇺🇸 US 🇨🇦 CA
Ultra StatIncludes seal
Fitment notes — MOTORAD 5523160
Ultra StatIncludes seal
160 Degrees FAlternate Temperature Option
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Performance

Brand Part Number Markets Notes Buy
MOTORAD Fits: 6.6L V8 2523160
🇺🇸 US 🇨🇦 CA
High FlowIncludes seal
Fitment notes — MOTORAD 2523160
High FlowIncludes seal
160 Degrees FAlternate Temperature Option
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MOTORAD Fits: 6.6L V8 MRD105
🇺🇸 US 🇨🇦 CA
RacingIncludes Thermostat and Seal
Fitment notes — MOTORAD MRD105
RacingIncludes Thermostat and Seal
Temperature 160F
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Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular Fits: 6.6L V8 131160
🇺🇸 US 🇨🇦 CA
GM Original Equipment
Fitment notes — ACDELCO 131160
GM Original Equipment
Fits:
6 speed Automatic trans.Single Use86 DEG C Thermostat. For 91 DEG C Thermostat See PN 19420815.or 6 speed Automatic trans.Single Use86 DEG C Thermostatfor 91 DEG C Thermostat See PN 19420815
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GATES Popular Fits: 6.6L V8 34198
🇺🇸 US 🇨🇦 CA
OE Type
Fitment notes — GATES 34198
OE Type
187 DegreeOE TemperatureSeal Included
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MOTORAD Popular Fits: 6.6L V8 523190
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523190
Includes Seal
187 Degrees FOE Specified Temperature
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MOTORAD Popular Fits: 6.6L V8 523160
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523160
Includes Seal
160 Degrees FAlternate Temperature Option
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MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged 447185
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 447185
Includes Seal
Front185 Degrees FOE Specified Temperature
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MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged 447448
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 447448
Includes Seal
Cylinder Head180 Degrees F or 185 Degrees FOE Specified Temperature
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AISIN Fits: 6.6L V8 THRGM0002
🇺🇸 US 🇨🇦 CA
Includes Thermostat SealWithout Integrated Housing
Fitment notes — AISIN THRGM0002
Includes Thermostat SealWithout Integrated Housing
86°
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CALORSTAT Fits: 6.6L V8 TH210786J
🇺🇸 US 🇨🇦 CA
Includes 1 Rubber Gasket
Fitment notes — CALORSTAT TH210786J
Includes 1 Rubber Gasket
187.0 F Degrees6 speed trans.with Larger Main Valve
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CALORSTAT Fits: 6.6L V8 TH210782J
🇺🇸 US 🇨🇦 CA
PerformanceIncludes 1 Rubber Gasket
Fitment notes — CALORSTAT TH210782J
PerformanceIncludes 1 Rubber Gasket
180.0 Degrees6 speed trans.with Larger Main Valve
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CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged TH152983J
🇺🇸 US 🇨🇦 CA
Includes 1 Paper Gasket
Fitment notes — CALORSTAT TH152983J
Includes 1 Paper Gasket
181.0 F Degrees
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CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged THK750582J
🇺🇸 US 🇨🇦 CA
KitIncludes 1 Rubber Gasket
Fitment notes — CALORSTAT THK750582J
KitIncludes 1 Rubber Gasket
180.0 Degrees
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GM GENUINE Fits: 6.6L V8 19420815
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — GM GENUINE 19420815
Includes Seal
6 speed Automatic trans.91 Degree Celsius Thermostat
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 131197
🇺🇸 US 🇨🇦 CA
GM Original EquipmentDoes Not Include O-Ring
Fitment notes — GM GENUINE 131197
GM Original EquipmentDoes Not Include O-Ring
Single Use185 Degree F or 85 Degree C Thermostatwithout GasketFront
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 131198
🇺🇸 US 🇨🇦 CA
Single UseRR
Fitment notes — GM GENUINE 131198
Single UseRROrder with Gasket/Seal 12680544180 Degree F Thermostat
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MAHLE / CLEVITE Fits: all 2021 Sierra 2500 engines TX49971D
🇺🇸 US 🇨🇦 CA
Opening Temperature 71with Seal
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MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged TX50282D
🇺🇸 US 🇨🇦 CA
Rear
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MOTORAD Fits: 6.6L V8 523174
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523174
Includes Seal
174 Degrees FAlternate Temperature Option
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MOTORAD Fits: 6.6L V8 523180
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 523180
Includes Seal
180 Degrees FAlternate Temperature Option
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MOTORAD Fits: 6.6L V8 5945KT
🇺🇸 US 🇨🇦 CA
Includes Thermostat and HousingKit
Fitment notes — MOTORAD 5945KT
Includes Thermostat and HousingKit
190 Degrees FOE Specified Temperature
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MOTORAD Fits: 6.6L V8 DIESEL Turbocharged 448180
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 448180
Includes Seal
Rear180 Degrees FOE Specified Temperature
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This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
FEL-PRO Fits: 6.6L V8 36219
🇺🇸 US 🇨🇦 CA
Thermostat Seal
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12643149
🇺🇸 US 🇨🇦 CA
SINGLE USE
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 94034146
🇺🇸 US 🇨🇦 CA
Single UseInside Diameter: 10.2 Outside Diameter: 15.2
Fitment notes — GM GENUINE 94034146
Single UseInside Diameter: 10.2 Outside Diameter: 15.2Water Outlet Adapter Gasket
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12680544
🇺🇸 US 🇨🇦 CA
Single UseThermostat Seal
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MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged C33723
🇺🇸 US 🇨🇦 CA
Beaded Steel
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VICTOR REINZ Fits: 6.6L V8 711357800
🇺🇸 US 🇨🇦 CA
Thermostat Seal
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This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Thermostat Housing / Water Outlet

Economy

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.6L V8 9022081
🇺🇸 US 🇨🇦 CA
Water PumpThermostat Housing
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Standard Replacement

Brand Part Number Markets Notes Buy
FOUR SEASONS Fits: 6.6L V8 85945
🇺🇸 US 🇨🇦 CA
Water Outlet
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MOTORAD Fits: 6.6L V8 CH5945
🇺🇸 US 🇨🇦 CA
Water Outlet
View on
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Brand Part Number Markets Notes Buy
FOUR SEASONS Popular Fits: 6.6L V8 DIESEL Turbocharged 85945
🇺🇸 US 🇨🇦 CA
Water Outlet
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12706111
🇺🇸 US 🇨🇦 CA
Gasket/Seal Not Included
Fitment notes — GM GENUINE 12706111
Gasket/Seal Not Included
Water Outlet
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12743523
🇺🇸 US 🇨🇦 CA
Thermostat Housing
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MOTORAD Fits: 6.6L V8 DIESEL Turbocharged CH3152
🇺🇸 US 🇨🇦 CA
Fits UpperWater Outlet
Fitment notes — MOTORAD CH3152
Fits:
UpperWater Outlet
or:
UpperThermostat Housing
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MOTORAD Fits: 6.6L V8 DIESEL Turbocharged CH1072
🇺🇸 US 🇨🇦 CA
Fits LowerThermostat Housing
Fitment notes — MOTORAD CH1072
Fits:
LowerThermostat Housing
or:
LowerWater Outlet
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This table covers the housings and outlets the thermostat sits in.

Water Inlet Gasket

Brand Part Number Markets Notes Buy
GM GENUINE Fits: all 2021 Sierra 2500 engines 12587397
🇺🇸 US 🇨🇦 CA
SINGLE USE
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This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump

Brand Part Number Markets Notes Buy
GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged 251817
🇺🇸 US 🇨🇦 CA
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ACDELCO Fits: 6.6L V8 DIESEL Turbocharged 2521039
🇺🇸 US 🇨🇦 CA
GoldDoes Not Include Mount Bolts
Fitment notes — ACDELCO 2521039
GoldDoes Not Include Mount BoltsThermostat and Housing Included: No
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FVP Fits: 6.6L V8 1303210
🇺🇸 US 🇨🇦 CA
View on
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GATES Fits: 6.6L V8 DIESEL Turbocharged 42229
🇺🇸 US 🇨🇦 CA
View on
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GM GENUINE Fits: 6.6L V8 12735409
🇺🇸 US 🇨🇦 CA
Includes Thermostat
Fitment notes — GM GENUINE 12735409
Includes Thermostat
6 speed Automatic trans.
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GMB Fits: 6.6L V8 1303210
🇺🇸 US 🇨🇦 CA
View on
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GMB Fits: 6.6L V8 DIESEL Turbocharged 1304030
🇺🇸 US 🇨🇦 CA
PUMP without HOUSING
View on
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GMB Fits: 6.6L V8 DIESEL Turbocharged 1304030AH
🇺🇸 US 🇨🇦 CA
Includes Housing
View on
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This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Water Pump Gasket

Brand Part Number Markets Notes Buy
FEL-PRO Fits: 6.6L V8 36110
🇺🇸 US 🇨🇦 CA
To BlockHousing To Block
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FEL-PRO Fits: 6.6L V8 36109
🇺🇸 US 🇨🇦 CA
To BlockPump To Housing
View on
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GM GENUINE Fits: 6.6L V8 2512073
🇺🇸 US 🇨🇦 CA
6 speed Automatic trans.
View on
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MAHLE / CLEVITE Fits: 6.6L V8 K33358
🇺🇸 US 🇨🇦 CA
SteelIncludes 2 Gaskets
Fitment notes — MAHLE / CLEVITE K33358
SteelIncludes 2 Gaskets
PUMP TO HOUSING
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MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged GS34037
🇺🇸 US 🇨🇦 CA
Contains All Gaskets Required For Water Pump Installation
Fitment notes — MAHLE / CLEVITE GS34037
Contains All Gaskets Required For Water Pump Installation
Mounting Gasket
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This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump Inlet Tube

Brand Part Number Markets Notes Buy
GATES Fits: 6.6L V8 DIESEL Turbocharged HHA161
🇺🇸 US 🇨🇦 CA
Pipe
Fitment notes — GATES HHA161
Pipe
To Water Pump
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This table covers the Water Pump Inlet tubes.

Water Pump Seal / O-Ring

Brand Part Number Markets Notes Buy
GM GENUINE Fits: all 2021 Sierra 2500 engines 2512031
🇺🇸 US 🇨🇦 CA
(OEM Design)
Fitment notes — GM GENUINE 2512031
(OEM Design)
OutletSingle UseID=43.7Seal
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GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged 12643779
🇺🇸 US 🇨🇦 CA
SINGLE USE
View on
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This table covers the Water Pump Seal O-rings. Typical signs include a seep at a fitting or a housing that weeps after a service. Lube the new O-ring with the fluid it will see, and do not roll it into the groove.

Buying Cooling System Parts for a 2021 GMC Sierra 2500

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Thermostat and Coolant / Antifreeze .

Frequently Asked Questions

How many cooling system parts fit the 2021 GMC Sierra 2500?

Our catalog currently lists 167 cooling system parts for the 2021 GMC Sierra 2500 across 31 subcategories and 36 brands, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Each part is matched to the engine(s) it fits.

Do cooling system parts differ between 2021 GMC Sierra 2500 engines?

Some do. 38 parts fit every engine; the other 129 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.

What are the signs of cooling system problems on a 2021 GMC Sierra 2500?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 GMC Sierra 2500 was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2021 GMC Sierra 2500?

First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2021 GMC Sierra 2500

Cooling System Parts for Other GMC Sierra 2500 Years

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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.