This page lists 110 cooling system parts for the 2021 GMC Sierra 3500, across 28 part types, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Every part shows its brand, manufacturer part number and fitment notes.
The cooling system system on the 2021 GMC Sierra 3500 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (17 parts), Radiator (10 parts) and Thermostat (10 parts). The other 25 part types cover the remaining 73 parts.
The 2021 GMC Sierra 3500 was sold with both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. 13 parts fit every engine; the other 97 are engine-specific. Each part shows which engine(s) it fits.
The most listed brands for 2021 GMC Sierra 3500 cooling system parts are GM GENUINE (41 parts), MOTORAD (9 parts) and PRESTONE (7 parts), plus 27 more brands. Quality grades include Standard Replacement, Economy and Premium.
17 parts on this 2021 GMC Sierra 3500 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including FVP MV5050GAL (Coolant / Antifreeze) and GM GENUINE 85119168 (Coolant Hose / Pipe). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: 6.6L V8 | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Popular Fits: all 2021 Sierra 3500 engines | MV5050GAL | 🇺🇸 US 🇨🇦 CA | Extended LifeAll Makes / All Models | View on Amazon |
| PEAK Fits: all 2021 Sierra 3500 engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Fits: all 2021 Sierra 3500 engines | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 Sierra 3500 engines | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: 6.6L V8 | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 Sierra 3500 engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 Sierra 3500 engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: 6.6L V8 | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: all 2021 Sierra 3500 engines | 105027 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon | View on Amazon |
| VALVOLINE Popular Fits: all 2021 Sierra 3500 engines | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| AISIN Fits: all 2021 Sierra 3500 engines | ACD005 | 🇺🇸 US 🇨🇦 CA | OrangeOAT | View on Amazon |
| FVP Fits: all 2021 Sierra 3500 engines | DEX5050GAL | 🇺🇸 US 🇨🇦 CA | Extended Life Blend1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 Sierra 3500 engines | AF3400 | 🇺🇸 US 🇨🇦 CA | Prime OrangeOrange Compatible | View on Amazon |
| PRESTONE Fits: all 2021 Sierra 3500 engines | AF850 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended Life1 Gallon | View on Amazon |
| VALVOLINE Fits: all 2021 Sierra 3500 engines | 888374 | 🇺🇸 US 🇨🇦 CA | American Vehicle Orange1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
17 Coolant / Antifreeze parts for the 2021 GMC Sierra 3500 come from 6 brands — PRESTONE, PEAK, VALVOLINE and 3 other brands. The "Popular" part is FVP MV5050GAL. 13 parts fit every engine; the other 4 are engine-specific.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 4 options from FVP, PEAK, PRESTONE and 1 other brand — the catalog's value-priced group. FVP MV5050GAL is listed in this group.
In the Heavy Duty grade, PRESTONE supplies 1 part: rated for severe service. A representative part number is PRESTONE AFC12100.
In the Premium grade, PRESTONE and PEAK supply 4 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, VALVOLINE, PRESTONE, ACDELCO and 2 other brands supply 7 parts: built to original-equipment specification. A representative part number is ACDELCO 105027.
Coolant Air Bleed Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549085 | 🇺🇸 US 🇨🇦 CA | CLAMP, SPRINGBAND, 13MM DIAMETER X 12 WIDE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056532 | 🇺🇸 US 🇨🇦 CA | Shape: Molded Assembly | View on Amazon |
This table covers the Coolant Air Bleed Hose pipes.
2 Coolant Air Bleed Hose / Pipe parts for the 2021 GMC Sierra 3500 come from GM GENUINE.
Part numbers include GM GENUINE 11549085 and GM GENUINE 85056532.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 85119168 | 🇺🇸 US 🇨🇦 CA | Expansion Tank Outlet | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85119158 | 🇺🇸 US 🇨🇦 CA | Auxiliary Radiator Outletwithout CLAMP | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12737234 | 🇺🇸 US 🇨🇦 CA | Thermostat Bypass | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056534 | 🇺🇸 US 🇨🇦 CA | Coolant Hose Heat Shield Included: YES | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85578389 | 🇺🇸 US 🇨🇦 CA | Fuel Cooler (Outlet) | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
5 Coolant Hose / Pipe parts for the 2021 GMC Sierra 3500 come from GM GENUINE. The "Popular" part is GM GENUINE 85119168.
Listed part numbers: GM GENUINE 85119168, GM GENUINE 85119158 and GM GENUINE 12737234, plus the other parts above.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 12658352 | 🇺🇸 US 🇨🇦 CA | Material: RubberOutside Diameter (mm): 31.54 mm | View on Amazon |
| AJUSA Fits: 6.6L V8 DIESEL Turbocharged | 16097400 | 🇺🇸 US 🇨🇦 CA | COOLANT PIPE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12737097 | 🇺🇸 US 🇨🇦 CA | Material: Stainless Steel | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33755 | 🇺🇸 US 🇨🇦 CA | Steel | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33756 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
5 Coolant Hose / Pipe Seal parts are listed for the 2021 GMC Sierra 3500, from GM GENUINE, MAHLE / CLEVITE and AJUSA. GM GENUINE 12658352 carries the "Popular" badge.
Part numbers include GM GENUINE 12658352, AJUSA 16097400 and GM GENUINE 12737097, among others listed above.
Coolant Hose Retainer / Clip
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11548857 | 🇺🇸 US 🇨🇦 CA | OutletTie Strap with Plastic Tree Fits 7.5-10.5MM Hole, 184MM Long | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11547354 | 🇺🇸 US 🇨🇦 CA | OutletFITS 19-24.5MM TUBE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11547355 | 🇺🇸 US 🇨🇦 CA | OutletFITS 25-31MM TUBE | View on Amazon |
This table covers the Coolant Hose retainers and clips.
3 Coolant Hose Retainer / Clip parts for the 2021 GMC Sierra 3500 come from GM GENUINE.
This group includes GM GENUINE 11548857, GM GENUINE 11547354 and GM GENUINE 11547355.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85639732 | 🇺🇸 US 🇨🇦 CA | Reservoir Material: Polypropylene (PP) | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
One part is listed for the 2021 GMC Sierra 3500 — GM GENUINE 85639732.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Popular Fits: 6.6L V8 DIESEL Turbocharged | 54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SKP Popular Fits: 6.6L V8 DIESEL Turbocharged | SK54218 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged | RC0144 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 20.0 PS | View on Amazon |
| GATES Fits: 6.6L V8 DIESEL Turbocharged | 31569 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | T62 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | T130 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
6 Coolant Reservoir Cap parts are listed for the 2021 GMC Sierra 3500, from MOTORAD, DORMAN, SKP and 2 other brands. DORMAN 54218 carries the "Popular" badge.
Part numbers include DORMAN 54218, SKP SK54218 and CALORSTAT RC0144, among others listed above.
Cooling System Tester Adapter
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | 3128 | 🇺🇸 US 🇨🇦 CA | StandardRadiator Cap Adapter | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | 3127 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the adapters used to pressure-test this cooling system.
2 Cooling System Tester Adapter parts for the 2021 GMC Sierra 3500 come from MOTORAD.
This group includes MOTORAD 3128 and MOTORAD 3127.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 11570871 | 🇺🇸 US 🇨🇦 CA | Gray | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549085 | 🇺🇸 US 🇨🇦 CA | Fits Clamp, Springband, 13MM Diameter X 12 WideAir Bleed Hose | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11549298 | 🇺🇸 US 🇨🇦 CA | Fits Lower32.0 X 12.0 | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 90530642 | 🇺🇸 US 🇨🇦 CA | Fits Clamp-Sprindband, 14X12, Double BandAir Bleed Hos | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 11548772 | 🇺🇸 US 🇨🇦 CA | LowerClamp, Springband, Normally Closed | View on Amazon |
This table covers the Hose clamps.
5 Hose Clamp parts for the 2021 GMC Sierra 3500 come from GM GENUINE. The "Popular" part is GM GENUINE 11570871.
Listed part numbers: GM GENUINE 11570871, GM GENUINE 11549085 and GM GENUINE 11549298, plus the other parts above.
Intercooler
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TECHPRO Fits: 6.6L V8 DIESEL Turbocharged | GM3012129 | 🇺🇸 US 🇨🇦 CA | HD Model | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 84747171 | 🇺🇸 US 🇨🇦 CA | Mounting Hardware Included: YES | View on Amazon |
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TYC Fits: 6.6L V8 DIESEL Turbocharged | 18145 | 🇺🇸 US 🇨🇦 CA | DIESEL | View on Amazon |
| VARIOUS MFR Fits: 6.6L V8 DIESEL Turbocharged | GM3012129 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the intercoolers that cool turbo or supercharger charge air.
4 Intercooler parts for the 2021 GMC Sierra 3500 come from 4 brands — TECHPRO, GM GENUINE, TYC and 1 other brand.
The Economy section: 1 option from TECHPRO. TECHPRO GM3012129 is listed in this group.
Standard Replacement: 1 part, from GM GENUINE. A representative part number is GM GENUINE 84747171.
2 further parts sit outside the graded sections, with the same engine-level match.
Part numbers include TECHPRO GM3012129, GM GENUINE 84747171 and TYC 18145, among others listed above.
Intercooler Air Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.6L V8 DIESEL Turbocharged | 667828 | 🇺🇸 US 🇨🇦 CA | Turbocharger To Intercooler (Hot Side) | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 84870726 | 🇺🇸 US 🇨🇦 CA | End 1 Inside Diameter (In): 3.08 In | View on Amazon |
| SKP Fits: 6.6L V8 DIESEL Turbocharged | SK84870726 | 🇺🇸 US 🇨🇦 CA | Air Inlet | View on Amazon |
This table covers the Intercooler Air Hose pipes.
3 Intercooler Air Hose / Pipe parts for the 2021 GMC Sierra 3500 come from 3 brands — DORMAN, GM GENUINE and SKP.
Part numbers include DORMAN 667828, GM GENUINE 84870726 and SKP SK84870726.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: 6.6L V8 DIESEL Turbocharged | 13893C | 🇺🇸 US 🇨🇦 CA | Auxiliary | View on Amazon |
| GPD Fits: 6.6L V8 DIESEL Turbocharged | 13879C | 🇺🇸 US 🇨🇦 CA | PRIMARY | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Popular Fits: 6.6L V8 DIESEL Turbocharged | 3938 | 🇺🇸 US 🇨🇦 CA | Auxiliary Radiator | View on Amazon |
| CSF Popular Fits: 6.6L V8 DIESEL Turbocharged | 3928 | 🇺🇸 US 🇨🇦 CA | with Quick-Connect Outlet Pipe & Quick-Connect Oil Cooler Fittings. | View on Amazon |
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 84799449 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 21978 | 🇺🇸 US 🇨🇦 CA | Aluminum Core / Aluminum Tank | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85610318 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| KOYORAD Fits: 6.6L V8 DIESEL Turbocharged | A13879 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SPECTRA PREMIUM Fits: 6.6L V8 DIESEL Turbocharged | CU13879 | 🇺🇸 US 🇨🇦 CA | Main Unit | View on Amazon |
| TYC Fits: 6.6L V8 DIESEL Turbocharged | 13879 | 🇺🇸 US 🇨🇦 CA | Crew Cab Pickup or Extended Cab Pickup or Standard Cab Pickup | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
10 Radiator parts for the 2021 GMC Sierra 3500 come from 7 brands — GPD, CSF, GM GENUINE and 4 other brands. The "Popular" part is CSF 3938.
The Economy section: 2 options from GPD. GPD 13893C is listed in this group.
Standard Replacement: 8 parts, from CSF, GM GENUINE, ACDELCO and 3 other brands. A representative part number is CSF 3938.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | RC124 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| PROFESSIONAL PARTS SWEDEN Fits: 6.6L V8 DIESEL Turbocharged | 21342353 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
2 Radiator Cap parts for the 2021 GMC Sierra 3500 come from 2 brands — ACDELCO and PROFESSIONAL PARTS SWEDEN.
Listed part numbers: ACDELCO RC124 and PROFESSIONAL PARTS SWEDEN 21342353.
Radiator Drain Petcock
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 22790134 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the petcocks used to drain the radiator.
One part is listed for the 2021 GMC Sierra 3500 — GM GENUINE 22790134.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 1582003 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
One part is listed for the 2021 GMC Sierra 3500 — GM GENUINE 1582003.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85824793 | 🇺🇸 US 🇨🇦 CA | 4WD | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
This group shows a single part: GM GENUINE 85824793.
Radiator Fan Pulley
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12714130 | 🇺🇸 US 🇨🇦 CA | Only For 4WD Applications | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12714129 | 🇺🇸 US 🇨🇦 CA | Only For 2WD Applications.28" Fan | View on Amazon |
This table covers the Radiator Fan pulleys. Typical signs include a growl or chirp that follows engine speed, or a pulley that will not spin freely by hand. Spin each pulley with the belt off. Roughness or play means replace it with the belt.
2 Radiator Fan Pulley parts for the 2021 GMC Sierra 3500 come from GM GENUINE.
This group includes GM GENUINE 12714130 and GM GENUINE 12714129.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 87868034 | 🇺🇸 US 🇨🇦 CA | Rearward | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
This group shows a single part: GM GENUINE 87868034.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 85122989 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 85056546 | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
2 Radiator Hose parts are listed for the 2021 GMC Sierra 3500, from ACDELCO and GM GENUINE.
Part numbers include ACDELCO 85122989 and GM GENUINE 85056546.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ULTRA-POWER Popular Fits: 6.6L V8 DIESEL Turbocharged | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.6L V8 DIESEL Turbocharged | 1712496 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: 6.6L V8 DIESEL Turbocharged | 2CTS0184 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| STANDARD MOTOR PRODUCTS Popular Fits: 6.6L V8 DIESEL Turbocharged | TX247 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FACET Fits: 6.6L V8 DIESEL Turbocharged | 73379 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Oblong | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 25186240 | 🇺🇸 US 🇨🇦 CA | Mating Connector Use 13587326 | View on Amazon |
| WALKER PRODUCTS Fits: 6.6L V8 DIESEL Turbocharged | 2112015 | 🇺🇸 US 🇨🇦 CA | SensorIncludes O-Ring | View on Amazon |
| WELLS Fits: 6.6L V8 DIESEL Turbocharged | 5S13427 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
8 Temperature Sender / Sensor parts for the 2021 GMC Sierra 3500 come from 8 brands — ULTRA-POWER, GPD, HOLSTEIN and 5 other brands. The "Popular" part is ULTRA-POWER 5S13427.
The Economy section: 3 options from ULTRA-POWER, GPD and HOLSTEIN. ULTRA-POWER 5S13427 is listed in this group.
Standard Replacement: 5 parts, from STANDARD MOTOR PRODUCTS, FACET, GM GENUINE and 2 other brands. A representative part number is STANDARD MOTOR PRODUCTS TX247.
Listed part numbers: ULTRA-POWER 5S13427, GPD 1712496 and HOLSTEIN 2CTS0184, plus the other parts above.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Fits: 6.6L V8 DIESEL Turbocharged | SK131160 | 🇺🇸 US 🇨🇦 CA | 190 Degree | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged | 447185 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 6.6L V8 DIESEL Turbocharged | 447448 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged | TH152983J | 🇺🇸 US 🇨🇦 CA | Includes 1 Paper Gasket | View on Amazon |
| CALORSTAT Fits: 6.6L V8 DIESEL Turbocharged | THK750582J | 🇺🇸 US 🇨🇦 CA | KitIncludes 1 Rubber Gasket | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 131197 | 🇺🇸 US 🇨🇦 CA | GM Original EquipmentDoes Not Include O-Ring | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 131198 | 🇺🇸 US 🇨🇦 CA | Single UseRR | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | TX49971D | 🇺🇸 US 🇨🇦 CA | Opening Temperature 71with Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | TX50282D | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | 448180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
10 Thermostat parts are listed for the 2021 GMC Sierra 3500, from MOTORAD, CALORSTAT, GM GENUINE and 2 other brands. MOTORAD 447185 carries the "Popular" badge.
Economy: 1 part, from SKP. A representative part number is SKP SK131160.
The Standard Replacement section: 9 options from MOTORAD, CALORSTAT, GM GENUINE and 1 other brand. MOTORAD 447185 is listed in this group.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12643149 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 94034146 | 🇺🇸 US 🇨🇦 CA | Single UseInside Diameter: 10.2 Outside Diameter: 15.2 | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12680544 | 🇺🇸 US 🇨🇦 CA | Single UseThermostat Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | C33723 | 🇺🇸 US 🇨🇦 CA | Beaded Steel | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
4 Thermostat / Thermostat Housing / Water Outlet Seal parts for the 2021 GMC Sierra 3500 come from 2 brands — GM GENUINE and MAHLE / CLEVITE.
Part numbers include GM GENUINE 12643149, GM GENUINE 94034146 and GM GENUINE 12680544, among others listed above.
Thermostat Housing / Water Outlet
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Popular Fits: 6.6L V8 DIESEL Turbocharged | 85945 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12706111 | 🇺🇸 US 🇨🇦 CA | Gasket/Seal Not Included | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12743523 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | CH3152 | 🇺🇸 US 🇨🇦 CA | Fits UpperWater Outlet | View on Amazon |
| MOTORAD Fits: 6.6L V8 DIESEL Turbocharged | CH1072 | 🇺🇸 US 🇨🇦 CA | Fits LowerThermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
5 Thermostat Housing / Water Outlet parts are listed for the 2021 GMC Sierra 3500, from GM GENUINE, MOTORAD and FOUR SEASONS. FOUR SEASONS 85945 carries the "Popular" badge.
Listed part numbers: FOUR SEASONS 85945, GM GENUINE 12706111 and GM GENUINE 12743523, plus the other parts above.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12587397 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
This group shows a single part: GM GENUINE 12587397.
Water Pump
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 6.6L V8 DIESEL Turbocharged | 251817 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| ACDELCO Fits: 6.6L V8 DIESEL Turbocharged | 2521039 | 🇺🇸 US 🇨🇦 CA | GoldDoes Not Include Mount Bolts | View on Amazon |
| GATES Fits: 6.6L V8 DIESEL Turbocharged | 42229 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 6.6L V8 DIESEL Turbocharged | 1304030 | 🇺🇸 US 🇨🇦 CA | PUMP without HOUSING | View on Amazon |
| GMB Fits: 6.6L V8 DIESEL Turbocharged | 1304030AH | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
5 Water Pump parts are listed for the 2021 GMC Sierra 3500, from GMB, GM GENUINE, ACDELCO and 1 other brand. GM GENUINE 251817 carries the "Popular" badge.
This group includes GM GENUINE 251817, ACDELCO 2521039 and GATES 42229 and the remaining parts above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE Fits: 6.6L V8 DIESEL Turbocharged | GS34037 | 🇺🇸 US 🇨🇦 CA | Contains All Gaskets Required For Water Pump Installation | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
This group shows a single part: MAHLE / CLEVITE GS34037.
Water Pump Inlet Tube
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Fits: 6.6L V8 DIESEL Turbocharged | HHA161 | 🇺🇸 US 🇨🇦 CA | Pipe | View on Amazon |
This table covers the Water Pump Inlet tubes.
One part is listed for the 2021 GMC Sierra 3500 — GATES HHA161.
Water Pump Seal / O-Ring
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 12643779 | 🇺🇸 US 🇨🇦 CA | SINGLE USE | View on Amazon |
| GM GENUINE Fits: 6.6L V8 DIESEL Turbocharged | 2512031 | 🇺🇸 US 🇨🇦 CA | (OEM Design) | View on Amazon |
This table covers the Water Pump Seal O-rings. Typical signs include a seep at a fitting or a housing that weeps after a service. Lube the new O-ring with the fluid it will see, and do not roll it into the groove.
GM GENUINE supplies both parts for the 2021 GMC Sierra 3500.
Part numbers include GM GENUINE 12643779 and GM GENUINE 2512031.
Buying Cooling System Parts for a 2021 GMC Sierra 3500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Radiator .
Frequently Asked Questions
How many cooling system parts fit the 2021 GMC Sierra 3500?
Our catalog currently lists 110 cooling system parts for the 2021 GMC Sierra 3500 across 28 subcategories and 30 brands, covering both the 6.6L V8 and the 6.6L V8 DIESEL Turbocharged. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 GMC Sierra 3500 engines?
Some do. 13 parts fit every engine; the other 97 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 GMC Sierra 3500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 GMC Sierra 3500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 GMC Sierra 3500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 GMC Sierra 3500
Cooling System Parts for Other GMC Sierra 3500 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.