2006 Isuzu NPR Cooling System Parts

Engine:

Showing parts for every engine. Select an engine to see only what fits.

91 Cooling system parts are listed for the 2006 Isuzu NPR, in 13 part types, covering both the 5.2L L4 DIESEL Turbocharged and the 6.0L V8. Each one has a brand, a manufacturer part number and notes that say where it fits.

On the 2006 Isuzu NPR, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. 41 parts of the 91 listed are Coolant / Antifreeze (14 parts), Water Pump (14 parts) and Radiator Hose (13 parts). The other 10 part types cover the remaining 50 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE Fits: all 2006 NPR engines AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
Fits:
NPR-HD
or:
NPR Base ModelExcept Class 8 Applications
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Economy

Brand Part Number Markets Notes Buy
FVP Popular Fits: all 2006 NPR engines MV5050GAL
🇺🇸 US 🇨🇦 CA
Extended LifeAll Makes / All Models
Fitment notes — FVP MV5050GAL
Extended LifeAll Makes / All Models1 Gallon
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PEAK Fits: all 2006 NPR engines BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
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PRESTONE Fits: all 2006 NPR engines AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
Fits:
NPR-HD
or:
NPR Base ModelExcept Class 8 Applications
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VALVOLINE Fits: all 2006 NPR engines 719009
🇺🇸 US 🇨🇦 CA
Multi-Vehicle Yellow1 Gallon
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Heavy Duty

Brand Part Number Markets Notes Buy
PEAK Fits: all 2006 NPR engines FXA1GAL
🇺🇸 US 🇨🇦 CA
Final Charge Global1 Gallon
Fitment notes — PEAK FXA1GAL
Final Charge Global1 GallonFINAL CHARGENITRITE FREEGLOBAL EXTENDED LIFE 1 GALLON
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PRESTONE Fits: all 2006 NPR engines AFC13000
🇺🇸 US 🇨🇦 CA
Command COR-Guard Nitrite Free-Noat Extended Life CoolantRed
Fitment notes — PRESTONE AFC13000
Command COR-Guard Nitrite Free-Noat Extended Life CoolantRed1 Galloncon
NPR Base ModelClass 7 Applications
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PRESTONE Fits: all 2006 NPR engines AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
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Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular Fits: all 2006 NPR engines AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
Fits:
NPR-HD
or:
NPR Base ModelExcept Class 8 Applications
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PEAK Fits: all 2006 NPR engines PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
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PEAK Fits: all 2006 NPR engines PXA1GAL
🇺🇸 US 🇨🇦 CA
1 GallonGlobal Lifetime
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PRESTONE Fits: all 2006 NPR engines AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
Fits:
NPR-HD
or:
NPR Base ModelExcept Class 8 Applications
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Standard Replacement

Brand Part Number Markets Notes Buy
VALVOLINE Popular Fits: all 2006 NPR engines ZXEL1
🇺🇸 US 🇨🇦 CA
Dex-Cool Orange1 Gallon
Fitment notes — VALVOLINE ZXEL1
Dex-Cool Orange1 GallonOAT
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VALVOLINE Fits: all 2006 NPR engines 675130
🇺🇸 US 🇨🇦 CA
Asian Vehicle Red1 Gallon
Fitment notes — VALVOLINE 675130
Asian Vehicle Red1 GallonPOAT
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This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Reservoir

Brand Part Number Markets Notes Buy
DORMAN Fits: all 2006 NPR engines 6035603
🇺🇸 US 🇨🇦 CA
Fits NPR Base Modelor NPR-HDSingle Cab
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This table covers the overflow / expansion tanks that hold extra coolant.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
DORMAN Fits: all 2006 NPR engines 9241059
🇺🇸 US 🇨🇦 CA
Single Cab
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This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Cooling System Tester Adapter

Brand Part Number Markets Notes Buy
GATES Fits: all 2006 NPR engines 31428
🇺🇸 US 🇨🇦 CA
May Require Spacer Number 31416
Fitment notes — GATES 31428
May Require Spacer Number 31416
Cooling System Pressure
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MOTORAD Fits: all 2006 NPR engines 3121
🇺🇸 US 🇨🇦 CA
StandardRadiator Cap Adapter
Fitment notes — MOTORAD 3121
StandardRadiator Cap Adapter
Cooling System PressureRadiator Cap Adapter
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MOTORAD Fits: all 2006 NPR engines 3122
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD 3122
Standard
Cooling System Pressure
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STANT Fits: all 2006 NPR engines 12021
🇺🇸 US 🇨🇦 CA
Radiator Cap/Cooling System Tester Adapter
Fitment notes — STANT 12021
Radiator Cap/Cooling System Tester Adapter
Cooling System PressureRadiator Cap Adapter
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This table covers the adapters used to pressure-test this cooling system.

Intercooler

Brand Part Number Markets Notes Buy
CSF Fits: 5.2L L4 DIESEL Turbocharged 6050
🇺🇸 US 🇨🇦 CA
Tube & Fin
Fitment notes — CSF 6050
Tube & Fin
with Aluminum Tanks
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GPD Fits: 5.2L L4 DIESEL Turbocharged 2711271
🇺🇸 US 🇨🇦 CA
with 21.63 IN X 14.5 IN X 2In Corewith 2.75 IN Inlet
Fitment notes — GPD 2711271
with 21.63 IN X 14.5 IN X 2In Corewith 2.75 IN Inletwith 2.75 IN Outlets
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SPECTRA PREMIUM Fits: 5.2L L4 DIESEL Turbocharged 44010707
🇺🇸 US 🇨🇦 CA
21-5/8" X 14-1/2" X 2 in. Core2-3/4" Inlet / 2-3/4" Outlet
Fitment notes — SPECTRA PREMIUM 44010707
21-5/8" X 14-1/2" X 2 in. Core2-3/4" Inlet / 2-3/4" Outlet
with 21.625 IN X 14.5 IN X 2In Corewith 2.75 IN Inletwith 2.75 IN Outlets
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This table covers the intercoolers that cool turbo or supercharger charge air.

Radiator

Economy

Brand Part Number Markets Notes Buy
GPD Fits: 5.2L L4 DIESEL Turbocharged 9243219
🇺🇸 US 🇨🇦 CA
HD
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GPD Fits: 6.0L V8 9243243
🇺🇸 US 🇨🇦 CA
All MetalHeavy Duty
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GPD Fits: 6.0L V8 9282730
🇺🇸 US 🇨🇦 CA
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ULTRA-POWER Fits: 5.2L L4 DIESEL Turbocharged 20010705
🇺🇸 US 🇨🇦 CA
24-1/2" X 23-3/8" X 1-1/4" CoreInlet 1-1/2" Upper Left Side
Fitment notes — ULTRA-POWER 20010705
24-1/2" X 23-3/8" X 1-1/4" CoreInlet 1-1/2" Upper Left SideOutlet 1-1/2" Lower Left Side
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Heavy Duty (All Metal Construction)

Brand Part Number Markets Notes Buy
CSF Fits: 5.2L L4 DIESEL Turbocharged 3219
🇺🇸 US 🇨🇦 CA
3 RowAll Metal Model with Sensor Port On Top Tank.
Fitment notes — CSF 3219
3 RowAll Metal Model with Sensor Port On Top Tank.Copper Core / Brass Tank
OE # 8-97333-140-0, 8-97333-140-4, 8-97333-141-0, 97333140, 97333141
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Standard Replacement

Brand Part Number Markets Notes Buy
CSF Popular Fits: 5.2L L4 DIESEL Turbocharged 3209
🇺🇸 US 🇨🇦 CA
1 RowPlastic Tank / Aluminum Core
Fitment notes — CSF 3209
1 RowPlastic Tank / Aluminum Corewith Sensor Port On Top Tank.
OE # 8-97333-140-0, 8-97333-140-4, 8-97333-141-0, 97333140, 97333141
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CSF Popular Fits: 6.0L V8 3242
🇺🇸 US 🇨🇦 CA
1 RowPlastic Tank / Aluminum Core
Fitment notes — CSF 3242
1 RowPlastic Tank / Aluminum CoreMulti Fit Model (Not Direct OE Match) with Sensor Port On Top tank
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OSC Fits: all 2006 NPR engines HD9217
🇺🇸 US 🇨🇦 CA
NPR Base Model24 7/16" Tall
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OSC Fits: 6.0L V8 HD1176
🇺🇸 US 🇨🇦 CA
Fits NPR-HD
Fitment notes — OSC HD1176
Fits:
NPR-HD
or:
NPR Base Model23-1/4" TallOutlet On Bottom Passenger Side
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UAC Fits: 6.0L V8 RA5000C
🇺🇸 US 🇨🇦 CA
Downflow
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Brand Part Number Markets Notes Buy
LILAND GLOBAL Fits: 6.0L V8 1000700
🇺🇸 US 🇨🇦 CA
Rad/CAC Assy
Fitment notes — LILAND GLOBAL 1000700
Rad/CAC Assy
NPR Base ModelIsuzu NPR31 Step COE Truckwith Charge Air Cooler/Intercooler Assembly
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LILAND GLOBAL Fits: 6.0L V8 2000700
🇺🇸 US 🇨🇦 CA
NPR Base ModelIsuzu NPR31 Step COE Truck
Fitment notes — LILAND GLOBAL 2000700
NPR Base ModelIsuzu NPR31 Step COE Truckwith Frame
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This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Locking Replacement

Brand Part Number Markets Notes Buy
CALORSTAT Fits: all 2006 NPR engines RC0212
🇺🇸 US 🇨🇦 CA
PerformanceIncludes 2 seals
Fitment notes — CALORSTAT RC0212
PerformanceIncludes 2 sealsLever OpeningMetallic
with A 44 mm (1.73") DiameterPSI - 20.0
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GATES Fits: all 2006 NPR engines 31534
🇺🇸 US 🇨🇦 CA
Safety Release Radiator Cap
Fitment notes — GATES 31534
Safety Release Radiator Cap
Check hood clearance prior to installing this cap
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MOTORAD Fits: all 2006 NPR engines ST16R
🇺🇸 US 🇨🇦 CA
Safety LeverIndicator Markings Color: Blue, Red
Fitment notes — MOTORAD ST16R
Safety LeverIndicator Markings Color: Blue, Red
Relief Pressure 16 lbs
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Standard Replacement

Brand Part Number Markets Notes Buy
MOTORAD Popular Fits: all 2006 NPR engines T16R
🇺🇸 US 🇨🇦 CA
StandardIndicator Markings Color: Silver
Fitment notes — MOTORAD T16R
StandardIndicator Markings Color: Silver
Relief Pressure 16 lbs
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SKP Popular Fits: all 2006 NPR engines SK10233
🇺🇸 US 🇨🇦 CA
Pressure Rating 16 psi
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CSF Fits: all 2006 NPR engines 4503
🇺🇸 US 🇨🇦 CA
Mini, 16 PSI
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GATES Fits: all 2006 NPR engines 31336
🇺🇸 US 🇨🇦 CA
OE Type
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This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
FOUR SEASONS Fits: 6.0L V8 36947
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — FOUR SEASONS 36947
Severe Duty Thermal
Standard Rotation
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HAYDEN Fits: 6.0L V8 2787
🇺🇸 US 🇨🇦 CA
ThermalSevere Duty
Fitment notes — HAYDEN 2787
ThermalSevere Duty
Standard Rotation
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NISSENS Fits: 6.0L V8 86465
🇺🇸 US 🇨🇦 CA
Severe Duty Thermal
Fitment notes — NISSENS 86465
Severe Duty Thermal
Standard Rotation
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SKP Fits: 6.0L V8 SK36947
🇺🇸 US 🇨🇦 CA
Thermal
Fitment notes — SKP SK36947
Thermal
Fits:
NPR Base ModelAssemblywith Reverse Rotationor NPR-HDwith Reverse RotationAssembly
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This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Hose

Brand Part Number Markets Notes Buy
CONTINENTAL Popular Fits: 5.2L L4 DIESEL Turbocharged 62699
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — CONTINENTAL 62699
Molded
Lower
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DAYCO Popular Fits: 6.0L V8 71538
🇺🇸 US 🇨🇦 CA
Curved
Fitment notes — DAYCO 71538
Curved
LowerCut to fit
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DAYCO Popular Fits: 6.0L V8 72193
🇺🇸 US 🇨🇦 CA
Curved
Fitment notes — DAYCO 72193
Curved
UPPERCUT TO FIT
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GATES Popular Fits: 5.2L L4 DIESEL Turbocharged 23096
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 23096
Molded
UpperEngine To Radiator
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ACDELCO Fits: 5.2L L4 DIESEL Turbocharged 20456S
🇺🇸 US 🇨🇦 CA
Professional / GoldMolded
Fitment notes — ACDELCO 20456S
Professional / GoldMolded
UpperEngine To Radiator
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ACDELCO Fits: 5.2L L4 DIESEL Turbocharged 24564L
🇺🇸 US 🇨🇦 CA
Professional / GoldMolded
Fitment notes — ACDELCO 24564L
Professional / GoldMolded
LowerEngine To Radiator
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CONTINENTAL Fits: 5.2L L4 DIESEL Turbocharged 62807
🇺🇸 US 🇨🇦 CA
MoldedEnd 2 Hose Inside Diameter: 1.62 In
Fitment notes — CONTINENTAL 62807
MoldedEnd 2 Hose Inside Diameter: 1.62 In
Upper
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CONTINENTAL Fits: 6.0L V8 66208
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — CONTINENTAL 66208
Molded
Upper
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CONTINENTAL Fits: 6.0L V8 66009
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — CONTINENTAL 66009
Molded
Lower
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DAYCO Fits: 5.2L L4 DIESEL Turbocharged 72040
🇺🇸 US 🇨🇦 CA
Curved
Fitment notes — DAYCO 72040
Curved
Upper
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GATES Fits: 5.2L L4 DIESEL Turbocharged 23095
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 23095
Molded
LowerEngine To Radiator
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GATES Fits: 6.0L V8 23098
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 23098
Molded
UpperEngine To Radiator
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GATES Fits: 6.0L V8 23097
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 23097
Molded
LowerEngine To Radiator
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This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.0L V8 926016
🇺🇸 US
NPR-HD
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STANDARD MOTOR PRODUCTS Fits: 6.0L V8 TX89T
🇺🇸 US
T-Series
Fitment notes — STANDARD MOTOR PRODUCTS TX89T
T-Series
NPR-HD
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Standard Replacement

Brand Part Number Markets Notes Buy
STANDARD MOTOR PRODUCTS Fits: 6.0L V8 TX89
🇺🇸 US
NPR-HD
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This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
DORMAN Fits: 6.0L V8 9022836
🇺🇸 US 🇨🇦 CA
Includes Housing
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SKP Fits: 6.0L V8 SK9022836
🇺🇸 US 🇨🇦 CA
Includes Housing
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Heavy Duty

Brand Part Number Markets Notes Buy
GATES Popular Fits: 6.0L V8 33963
🇺🇸 US 🇨🇦 CA
Heavy-Duty
Fitment notes — GATES 33963
Heavy-Duty
186 DegreeSeal Included
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GATES Fits: 5.2L L4 DIESEL Turbocharged 33964
🇺🇸 US 🇨🇦 CA
Heavy-Duty
Fitment notes — GATES 33964
Heavy-Duty
Driver Side188 DegreeSeal Included
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GATES Fits: 5.2L L4 DIESEL Turbocharged 33965
🇺🇸 US 🇨🇦 CA
Heavy-Duty
Fitment notes — GATES 33965
Heavy-Duty
Passenger Side185 DegreeSeal Included
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Standard Replacement

Brand Part Number Markets Notes Buy
MOTORAD Popular Fits: 6.0L V8 456187
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 456187
Includes Seal
187 Degrees FOE Specified Temperature
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MOTORAD Fits: 5.2L L4 DIESEL Turbocharged 405785
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 405785
Includes Seal
Passenger Side185 Degrees F
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MOTORAD Fits: 5.2L L4 DIESEL Turbocharged 405680
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 405680
Includes Seal
Driver Side180 Degrees FOE Specified Temperature
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MOTORAD Fits: 6.0L V8 400995
🇺🇸 US 🇨🇦 CA
195 Degrees FOE Specified Temperature 195 Degrees
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MOTORAD Fits: 6.0L V8 400980
🇺🇸 US 🇨🇦 CA
180 Degrees FOE Specified Temperature
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MOTORAD Fits: 6.0L V8 524190
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD 524190
Standard
OE Specified Temperature
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This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat Housing / Water Outlet

Economy

Brand Part Number Markets Notes Buy
AUTOTECNICA Fits: 6.0L V8 GM0718508
🇺🇸 US 🇨🇦 CA
UpperHousing Only
Fitment notes — AUTOTECNICA GM0718508
UpperHousing OnlyThermostat Housing
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DORMAN Fits: 6.0L V8 902836
🇺🇸 US 🇨🇦 CA
Does Not Include Thermostat
Fitment notes — DORMAN 902836
Does Not Include Thermostat
UpperThermostat Housing
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Standard Replacement

Brand Part Number Markets Notes Buy
GATES Fits: 6.0L V8 CO34923
🇺🇸 US 🇨🇦 CA
Thermostat CoverWater Outlet
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MOTORAD Fits: 6.0L V8 CH2836
🇺🇸 US 🇨🇦 CA
Water Outlet
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This table covers the housings and outlets the thermostat sits in.

Water Pump

Economy

Brand Part Number Markets Notes Buy
SKP Popular Fits: 6.0L V8 SK1307340
🇺🇸 US 🇨🇦 CA
without Thermostat
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US MOTOR WORKS Popular Fits: 6.0L V8 US64
🇺🇸 US 🇨🇦 CA
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FVP Fits: 6.0L V8 US64
🇺🇸 US 🇨🇦 CA
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FVP Fits: 6.0L V8 US64T
🇺🇸 US 🇨🇦 CA
Includes thermostat and thermostat housing
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SKP Fits: 6.0L V8 SK1307340AT
🇺🇸 US 🇨🇦 CA
Includes Thermostat & Flange
Fitment notes — SKP SK1307340AT
Includes Thermostat & Flange
Fits:
NPR Base Model187 Degree Start to Openor NPR-HD187 Degree Start to Open
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US MOTOR WORKS Fits: 6.0L V8 US64T
🇺🇸 US 🇨🇦 CA
Includes Thermostat and Housing
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High Volume / Pressure

Brand Part Number Markets Notes Buy
GATES Fits: 5.2L L4 DIESEL Turbocharged 42239HD
🇺🇸 US 🇨🇦 CA
Water Pump (Heavy-Duty)
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Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Fits: 5.2L L4 DIESEL Turbocharged WPG027
🇺🇸 US 🇨🇦 CA
No Gasket Required, Use "FIPG" Form In Place Gasket Sealant: AISIN #AB1207B1
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DAYCO Fits: 6.0L V8 DP998
🇺🇸 US 🇨🇦 CA
47mm Thermostat DiameterSerpentine Belt Driven
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FVP Fits: 5.2L L4 DIESEL Turbocharged 1401560
🇺🇸 US 🇨🇦 CA
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GATES Fits: 6.0L V8 45005
🇺🇸 US 🇨🇦 CA
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GMB Fits: 5.2L L4 DIESEL Turbocharged 1401560
🇺🇸 US 🇨🇦 CA
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GMB Fits: 6.0L V8 1307340
🇺🇸 US 🇨🇦 CA
2.05" Diameter Thermostat Opening
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GMB Fits: 6.0L V8 1307340AT
🇺🇸 US 🇨🇦 CA
Includes Thermostat
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This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Buying Cooling System Parts for a 2006 Isuzu NPR

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Coolant / Antifreeze and Water Pump .

Frequently Asked Questions

How many cooling system parts fit the 2006 Isuzu NPR?

Our catalog currently lists 91 cooling system parts for the 2006 Isuzu NPR across 13 subcategories and 28 brands, covering both the 5.2L L4 DIESEL Turbocharged and the 6.0L V8. Each part is matched to the engine(s) it fits.

Do cooling system parts differ between 2006 Isuzu NPR engines?

Some do. 28 parts fit every engine; the other 63 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.

What are the signs of cooling system problems on a 2006 Isuzu NPR?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2006 Isuzu NPR was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2006 Isuzu NPR?

First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2006 Isuzu NPR

Cooling System Parts for Other Isuzu NPR Years

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