7 Drivetrain parts are listed for the 2022 Lexus IS500, in 3 part types, covering the 5.0L V8 engine. Each one has a brand, a manufacturer part number and notes that say where it fits.
On the 2022 Lexus IS500, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. All 7 listed parts are Gear Oil (4 parts), Axle Shaft Seal (2 parts) and Differential Pinion Seal (1 part).
The 2022 Lexus IS500 came with a single engine, the 5.0L V8, and every part is verified against it.
4 brands supply drivetrain parts for the 2022 Lexus IS500, led by TIMKEN (3 parts), VALVOLINE (2 parts) and IDEMITSU (1 part), plus 1 more brand.
Each part number listed for the 2022 Lexus IS500 opens a page with every vehicle that part fits.
Axle Shaft Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN | SL260507 | 🇺🇸 US 🇨🇦 CA | Rear Left | View on Amazon |
| TIMKEN | SL260508 | 🇺🇸 US 🇨🇦 CA | Rear Right | View on Amazon |
This table covers the seals where an axle shaft exits the housing. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
TIMKEN supplies both parts for the 2022 Lexus IS500.
Listed part numbers: TIMKEN SL260507 and TIMKEN SL260508.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN | SL260600 | 🇺🇸 US | Rear | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2022 Lexus IS500 — TIMKEN SL260600.
Gear Oil
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| IDEMITSU | 30305024750 | 🇺🇸 US | 75W90 Racing Gear Oil1 Quart | View on Amazon |
| MOBIL | 104361 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-901 Quart | View on Amazon |
| VALVOLINE | 915052 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-85 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE | 915053 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-85 Gear Oil1 Quart Flex Fill | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
4 Gear Oil parts are listed for the 2022 Lexus IS500, from VALVOLINE, IDEMITSU and MOBIL.
This group includes IDEMITSU 30305024750, MOBIL 104361 and VALVOLINE 915052 and the remaining parts above.
Buying Drivetrain Parts for a 2022 Lexus IS500
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 5.0L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Gear Oil and Axle Shaft Seal .
Frequently Asked Questions
How many drivetrain parts fit the 2022 Lexus IS500?
Our catalog currently lists 7 drivetrain parts for the 2022 Lexus IS500 across 3 subcategories and 4 brands, covering the 5.0L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2022 Lexus IS500?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus IS500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Lexus IS500?
Every part on this page is matched to the 5.0L V8 engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Lexus IS500
Drivetrain Parts for Other Lexus IS500 Years
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