The 2022 Lexus LS500 has 8 drivetrain parts with verified fitment on this page — 3 part types and 3 brands, covering the 3.5L V6 Turbocharged engine. Each part includes a manufacturer part number and application notes.
On the 2022 Lexus LS500, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. All 8 listed parts are CV Axle (5 parts), Axle Shaft Seal (2 parts) and Differential Pinion Seal (1 part).
Every part on this page is matched to the 3.5L V6 Turbocharged — the only engine offered in the 2022 Lexus LS500.
The most listed brands for 2022 Lexus LS500 drivetrain parts are TIMKEN (3 parts), GSP (3 parts) and TOP NOTCH (2 parts).
1 part on this 2022 Lexus LS500 page carries a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — TOP NOTCH TN18299 (CV Axle). Click any part number to see every vehicle that part fits.
Axle Shaft Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN | SL260507 | 🇺🇸 US 🇨🇦 CA | Rear LeftAWD | View on Amazon |
| TIMKEN | SL260508 | 🇺🇸 US 🇨🇦 CA | Rear RightAWD | View on Amazon |
This table covers the seals where an axle shaft exits the housing. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
2 Axle Shaft Seal parts for the 2022 Lexus LS500 come from TIMKEN.
Listed part numbers: TIMKEN SL260507 and TIMKEN SL260508.
CV Axle
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TOP NOTCH Popular | TN18299 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
| GSP | NCV69306 | 🇺🇸 US 🇨🇦 CA | Rear RightAWD | View on Amazon |
| GSP | NCV69286 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
| GSP | NCV69285 | 🇺🇸 US 🇨🇦 CA | Front Right | View on Amazon |
| TOP NOTCH | TN18292 | 🇺🇸 US 🇨🇦 CA | Front Right | View on Amazon |
This table covers the complete CV axle shafts from differential (or hub) to wheel. Typical signs include a click in tight turns, grease flung around the wheel well, or a vibration that builds with speed. A torn boot caught early is a boot kit; caught late it is the whole axle. Torque the axle nut to the method in the notes.
5 CV Axle parts for the 2022 Lexus LS500 come from 2 brands — GSP and TOP NOTCH. The "Popular" part is TOP NOTCH TN18299.
This group includes TOP NOTCH TN18299, GSP NCV69306 and GSP NCV69286 and the remaining parts above.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN | SL260600 | 🇺🇸 US 🇨🇦 CA | RearAWD | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
This group shows a single part: TIMKEN SL260600.
Buying Drivetrain Parts for a 2022 Lexus LS500
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 3.5L V6 Turbocharged engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: CV Axle and Axle Shaft Seal .
Frequently Asked Questions
How many drivetrain parts fit the 2022 Lexus LS500?
Our catalog currently lists 8 drivetrain parts for the 2022 Lexus LS500 across 3 subcategories and 3 brands, covering the 3.5L V6 Turbocharged engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2022 Lexus LS500?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus LS500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Lexus LS500?
Every part on this page is matched to the 3.5L V6 Turbocharged engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Lexus LS500
Drivetrain Parts for Other Lexus LS500 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.