This page lists 45 cooling system parts for the 2022 Lexus RX350, across 7 part types, covering the 3.5L V6 engine. Every part shows its brand, manufacturer part number and fitment notes.
On the 2022 Lexus RX350, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. Most of the listed parts are Coolant / Antifreeze (16 parts), Radiator (11 parts) and Radiator Fan Assembly (9 parts). The other 4 part types cover the remaining 9 parts.
The 2022 Lexus RX350 came with a single engine, the 3.5L V6, and every part is verified against it.
21 brands supply cooling system parts for the 2022 Lexus RX350, led by PRESTONE (6 parts), PEAK (4 parts) and GATES (4 parts), plus 18 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2022 Lexus RX350. 9 parts have it, including PRESTONE AF2100 (Coolant / Antifreeze) and CSF 3827 (Radiator). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PEAK | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK | PXA1GAL | 🇺🇸 US 🇨🇦 CA | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE | AF6210 | 🇺🇸 US 🇨🇦 CA | MAX Original EquipmentAsian Red/Pink | View on Amazon |
| PRESTONE | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AISIN Popular | ACT002 | 🇺🇸 US 🇨🇦 CA | PinkHOAT | View on Amazon |
| BECK/ARNLEY Popular | 2521502 | 🇺🇸 US 🇨🇦 CA | Premium Extra Life Pink | View on Amazon |
| VALVOLINE Popular | 675130 | 🇺🇸 US 🇨🇦 CA | Asian Vehicle Red1 Gallon | View on Amazon |
| BECK/ARNLEY | 2521002 | 🇺🇸 US 🇨🇦 CA | Premium Red | View on Amazon |
| PEAK | PAR1GAL | 🇺🇸 US 🇨🇦 CA | OET Asian Extended Life Red1 Gallon | View on Amazon |
| PENTOSIN | 8115209 | 🇺🇸 US 🇨🇦 CA | Pentofrost A41 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
16 Coolant / Antifreeze parts are listed for the 2022 Lexus RX350, from PRESTONE, PEAK, VALVOLINE and 3 other brands. PRESTONE AF2100 carries the "Popular" badge.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, PEAK, PRESTONE and VALVOLINE supply 3 parts: the catalog's value-priced group. A representative part number is PEAK BQA1GAL.
The Heavy Duty section lists 1 option from PRESTONE — rated for severe service. PRESTONE AFC12100 is listed in this group.
The Premium section lists 5 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 6 options from BECK/ARNLEY, AISIN, VALVOLINE and 2 other brands — built to original-equipment specification. AISIN ACT002 is listed in this group.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD | T162 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
This group shows a single part: MOTORAD T162.
Cooling Fan Control Module
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES | FCM111 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS | RY1897 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| ULTRA-POWER | FCM111 | 🇺🇸 US 🇨🇦 CA | Engine COOLING FAN MODULE | View on Amazon |
This table covers the Cooling Fan control modules.
3 Cooling Fan Control Module parts for the 2022 Lexus RX350 come from 3 brands — GATES, STANDARD MOTOR PRODUCTS and ULTRA-POWER.
This group includes GATES FCM111 and STANDARD MOTOR PRODUCTS RY1897 and the remaining parts above.
Radiator
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Popular | 3827 | 🇺🇸 US 🇨🇦 CA | 1 Row11% Thicker Core 30mm vs OEM 27mm | View on Amazon |
| CSF Popular | 3820 | 🇺🇸 US 🇨🇦 CA | 1 Row11% Thicker Core 30mm vs OEM 27mm | View on Amazon |
| DENSO Popular | 2219571 | 🇺🇸 US 🇨🇦 CA | Fits RX350L | View on Amazon |
| DENSO | 2219511 | 🇺🇸 US 🇨🇦 CA | Standard Package | View on Amazon |
| NISSENS | 606544 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| OSC | 13602 | 🇺🇸 US 🇨🇦 CA | without Towing Package | View on Amazon |
| SPECTRA PREMIUM | CU13602 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TYC | 13602 | 🇺🇸 US 🇨🇦 CA | without Transmission Oil Cooler | View on Amazon |
| TYC | 13596 | 🇺🇸 US 🇨🇦 CA | PrimaryCanada Built | View on Amazon |
| UAC | RA13602C | 🇺🇸 US 🇨🇦 CA | Downflow | View on Amazon |
| UAC | RA13596C | 🇺🇸 US 🇨🇦 CA | Downflow | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
11 Radiator parts are listed for the 2022 Lexus RX350, from CSF, DENSO, TYC and 4 other brands. CSF 3827 carries the "Popular" badge.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES | 31412 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MOTORAD | T37 | 🇺🇸 US 🇨🇦 CA | StandardIncludes Hose | View on Amazon |
| SKP | SK10242 | 🇺🇸 US 🇨🇦 CA | 16 psi Pressure Rating | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
3 Radiator Cap parts are listed for the 2022 Lexus RX350, from GATES, MOTORAD and SKP.
This group includes GATES 31412, MOTORAD T37 and SKP SK10242.
Radiator Fan Assembly
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ULTRA-POWER Popular | 624190 | 🇺🇸 US 🇨🇦 CA | without Transmission Oil CoolerSport Utility | View on Amazon |
| GPD | 2812042 | 🇺🇸 US 🇨🇦 CA | with Factory Tow Package | View on Amazon |
| TECHPRO | LX3115141 | 🇺🇸 US 🇨🇦 CA | Canada Built Vehiclewithout Trans Oil Cooler | View on Amazon |
| ULTRA-POWER | 624180 | 🇺🇸 US 🇨🇦 CA | with Transmission Oil CoolerSport Utility | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TYC Popular | 624180 | 🇺🇸 US 🇨🇦 CA | with Transmission Oil Cooler | View on Amazon |
| AGILITY | 6010456 | 🇺🇸 US 🇨🇦 CA | with Transmission Oil Coolerwith Tow Package | View on Amazon |
| AGILITY | 6010457 | 🇺🇸 US 🇨🇦 CA | without Transmission Oil CoolerFor vehicle built in Japan | View on Amazon |
| TYC | 624190 | 🇺🇸 US 🇨🇦 CA | without Transmission Oil Cooler | View on Amazon |
| UAC | FA50634C | 🇺🇸 US 🇨🇦 CA | Radiator-Condenser Fan Assembly | View on Amazon |
This table covers the fan assemblies (and clutches, where listed) that pull air through the radiator.
9 Radiator Fan Assembly parts for the 2022 Lexus RX350 come from 6 brands — ULTRA-POWER, TYC, AGILITY and 3 other brands. The "Popular" part is ULTRA-POWER 624190.
The Economy section: 4 options from ULTRA-POWER, GPD and TECHPRO. ULTRA-POWER 624190 is listed in this group.
Standard Replacement: 5 parts, from TYC, AGILITY and UAC. A representative part number is TYC 624180.
This group includes ULTRA-POWER 624190, GPD 2812042 and TECHPRO LX3115141 and the remaining parts above.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES | 51559 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GATES | 51562 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
2 Radiator Hose parts for the 2022 Lexus RX350 come from GATES.
Listed part numbers: GATES 51559 and GATES 51562.
Buying Cooling System Parts for a 2022 Lexus RX350
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Confirm you have the 3.5L V6 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Radiator .
Frequently Asked Questions
How many cooling system parts fit the 2022 Lexus RX350?
Our catalog currently lists 45 cooling system parts for the 2022 Lexus RX350 across 7 subcategories and 21 brands, covering the 3.5L V6 engine. Each part is matched to the engine(s) it fits.
What are the signs of cooling system problems on a 2022 Lexus RX350?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus RX350 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Lexus RX350?
Every part on this page is matched to the 3.5L V6 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Lexus RX350
Cooling System Parts for Other Lexus RX350 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.