This page lists 153 cooling system parts for the 2021 Ram 4500, across 27 part types, covering both the 6.4L V8 and the 6.7L L6 DIESEL Turbocharged. Every part shows its brand, manufacturer part number and fitment notes.
The cooling system system on the 2021 Ram 4500 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Temperature Sender / Sensor (17 parts), Radiator Fan Clutch (12 parts) and Water Pump (12 parts). The other 24 part types cover the remaining 112 parts.
The 2021 Ram 4500 was sold with both the 6.4L V8 and the 6.7L L6 DIESEL Turbocharged. 16 parts fit every engine; the other 137 are engine-specific. Each part shows which engine(s) it fits.
The most listed brands for 2021 Ram 4500 cooling system parts are MOPAR (55 parts), DORMAN (9 parts) and GPD (8 parts), plus 26 more brands. Quality grades include Standard Replacement, Economy and Premium.
22 parts on this 2021 Ram 4500 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including PRESTONE AF3100 (Coolant / Antifreeze) and DORMAN 603840 (Coolant Reservoir). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 4500 engines | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 4500 engines | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| PEAK Fits: all 2021 4500 engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2021 4500 engines | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2021 4500 engines | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2021 4500 engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2021 4500 engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE Fits: all 2021 4500 engines | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| AISIN Fits: all 2021 4500 engines | ACD007 | 🇺🇸 US 🇨🇦 CA | PurpleOAT | View on Amazon |
| PEAK Fits: all 2021 4500 engines | NAP1GAL | 🇺🇸 US 🇨🇦 CA | OET North American Extended Life Purple1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
10 Coolant / Antifreeze parts for the 2021 Ram 4500 come from 3 brands — PRESTONE, PEAK and AISIN. The "Popular" part is PRESTONE AF3100. Every part fits both the 6.4L V8 and the 6.7L L6 DIESEL Turbocharged.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 2 options from PRESTONE and PEAK — the catalog's value-priced group. PRESTONE AF3100 is listed in this group.
In the Heavy Duty grade, PRESTONE supplies 1 part: rated for severe service. A representative part number is PRESTONE AFC12100.
In the Premium grade, PRESTONE and PEAK supply 4 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, AISIN and PEAK supply 2 parts: built to original-equipment specification. A representative part number is AISIN ACD007.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: 6.4L V8 | 68370509AB | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineOutlet | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68359826AD | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineVent | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68359815AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineReturn | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68370065AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Supply | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359813AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Vent | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359812AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Return | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359830AD | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Vent | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
7 Coolant Hose / Pipe parts for the 2021 Ram 4500 come from MOPAR.
This group includes MOPAR 68370509AB, MOPAR 68359826AD and MOPAR 68359815AA and the remaining parts above.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE Fits: 6.7L L6 DIESEL Turbocharged | G33890 | 🇺🇸 US 🇨🇦 CA | RubberEngine Coolant Outlet O-Ring | View on Amazon |
| MAHLE / CLEVITE Fits: 6.7L L6 DIESEL Turbocharged | G33891 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-Ring | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
MAHLE / CLEVITE supplies both parts for the 2021 Ram 4500.
Part numbers include MAHLE / CLEVITE G33890 and MAHLE / CLEVITE G33891.
Coolant Level Sensor
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68489744AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| STANDARD MOTOR PRODUCTS Fits: 6.7L L6 DIESEL Turbocharged | FLS346 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Coolant Level sensors. Typical signs include a warning lamp, a stored code, or a reading that drops out when the harness is wiggled. Inspect the connector and ground before replacing the sensor — wiring faults are often condemned as bad sensors.
2 Coolant Level Sensor parts for the 2021 Ram 4500 come from 2 brands — MOPAR and STANDARD MOTOR PRODUCTS.
Listed part numbers: MOPAR 68489744AA and STANDARD MOTOR PRODUCTS FLS346.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Popular Fits: 6.4L V8 | 603840 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.4L V8 | 2411293 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOPAR Fits: 6.4L V8 | 68184910AE | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1or Heavy Duty HEMI MDS Engine | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68370066AC | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| TECHPRO Fits: 6.4L V8 | CH3014187 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TECHPRO Fits: 6.4L V8 | CH3014188 | 🇺🇸 US 🇨🇦 CA | Includes Cap | View on Amazon |
| TECHPRO Fits: 6.7L L6 DIESEL Turbocharged | CH3014186 | 🇺🇸 US 🇨🇦 CA | Includes Cap | View on Amazon |
| TECHPRO Fits: 6.7L L6 DIESEL Turbocharged | CH3014185 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
8 Coolant Reservoir parts are listed for the 2021 Ram 4500, from TECHPRO, MOPAR, DORMAN and 1 other brand. DORMAN 603840 carries the "Popular" badge.
Part numbers include DORMAN 603840, GPD 2411293 and MOPAR 68184910AE, among others listed above.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: all 2021 4500 engines | T73 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
One part is listed for the 2021 Ram 4500 — MOTORAD T73.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Popular Fits: 6.4L V8 | 52006750 | 🇺🇸 US 🇨🇦 CA | 60X15 | View on Amazon |
| MOPAR Popular Fits: 6.4L V8 | 32002370 | 🇺🇸 US 🇨🇦 CA | 53X15 | View on Amazon |
| MOPAR Fits: 6.4L V8 | 6033135 | 🇺🇸 US 🇨🇦 CA | 58X15 | View on Amazon |
| MOPAR Fits: all 2021 4500 engines | 6506848AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Heater Hose | View on Amazon |
| MOPAR Fits: 6.4L V8 | 6512744AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Regular Cab Chassis Wheelbase 3or Heavy Duty HEMI MDS Engine. | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68433819AA | 🇺🇸 US 🇨🇦 CA | 22x12 | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68211466AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 55056718AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359595AC | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
This table covers the Hose clamps.
9 Hose Clamp parts for the 2021 Ram 4500 come from MOPAR. The "Popular" part is MOPAR 52006750. 1 part fits every engine; the other 8 are engine-specific.
Listed part numbers: MOPAR 52006750, MOPAR 32002370 and MOPAR 6033135, plus the other parts above.
Intercooler
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Fits: 6.7L L6 DIESEL Turbocharged | 6101 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.7L L6 DIESEL Turbocharged | 2711410 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TECHPRO Fits: 6.7L L6 DIESEL Turbocharged | CH3012114 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the intercoolers that cool turbo or supercharger charge air.
3 Intercooler parts for the 2021 Ram 4500 come from 3 brands — CSF, GPD and TECHPRO.
Listed part numbers: CSF 6101, GPD 2711410 and TECHPRO CH3012114.
Intercooler Air Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.7L L6 DIESEL Turbocharged | 667031 | 🇺🇸 US 🇨🇦 CA | Intercooler to Engine (Cold Side) | View on Amazon |
| DORMAN Fits: 6.7L L6 DIESEL Turbocharged | 667030 | 🇺🇸 US 🇨🇦 CA | Turbocharger To Intercooler (Hot Side) | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68357482AB | 🇺🇸 US 🇨🇦 CA | Charge Air Cooler DuctInlet | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68417829AC | 🇺🇸 US 🇨🇦 CA | Charge Air Cooler DuctOutlet | View on Amazon |
This table covers the Intercooler Air Hose pipes.
4 Intercooler Air Hose / Pipe parts for the 2021 Ram 4500 come from 2 brands — DORMAN and MOPAR.
Part numbers include DORMAN 667031, DORMAN 667030 and MOPAR 68357482AB, among others listed above.
Intercooler Hose / Pipe Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.7L L6 DIESEL Turbocharged | 55247 | 🇺🇸 US 🇨🇦 CA | OutletPower Band 3.75 - 4.5" | View on Amazon |
| DORMAN Fits: 6.7L L6 DIESEL Turbocharged | 55246 | 🇺🇸 US 🇨🇦 CA | OutletAt Cooler | View on Amazon |
This table covers the Intercooler Hose / Pipe clamps.
DORMAN supplies both parts for the 2021 Ram 4500.
Part numbers include DORMAN 55247 and DORMAN 55246.
Intercooler Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68322667AD | 🇺🇸 US 🇨🇦 CA | Charge Air Cooler Seal | View on Amazon |
This table covers the seals at the Intercooler. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2021 Ram 4500 — MOPAR 68322667AD.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: 6.4L V8 | 13895C | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TECHPRO Fits: 6.4L V8 | CH3010389 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TECHPRO Fits: 6.7L L6 DIESEL Turbocharged | CH3010390 | 🇺🇸 US 🇨🇦 CA | with High Output Engine | View on Amazon |
| TECHPRO Fits: 6.7L L6 DIESEL Turbocharged | CH3010391 | 🇺🇸 US 🇨🇦 CA | without High Output Engine | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Popular Fits: 6.7L L6 DIESEL Turbocharged | 3944 | 🇺🇸 US 🇨🇦 CA | Upgraded Core. 17% Thicker 2 Row 42mm core vs OEM 1 Row 36mm coreUpgraded 16% Stronger Core | View on Amazon |
| CSF Popular Fits: 6.7L L6 DIESEL Turbocharged | 3937 | 🇺🇸 US 🇨🇦 CA | Upgraded Core. 17% Thicker 2 Row 42mm core vs OEM 1 Row 36mm coreUpgraded 16% Stronger Core | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68322493AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1 | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68322491AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 4 | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68322492AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3 | View on Amazon |
| SPECTRA PREMIUM Fits: 6.7L L6 DIESEL Turbocharged | CU13871 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
10 Radiator parts for the 2021 Ram 4500 come from 5 brands — TECHPRO, MOPAR, CSF and 2 other brands. The "Popular" part is CSF 3944.
The Economy section: 4 options from TECHPRO and GPD. GPD 13895C is listed in this group.
Standard Replacement: 6 parts, from MOPAR, CSF and SPECTRA PREMIUM. A representative part number is CSF 3944.
Radiator Fan Assembly
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Fits: 6.4L V8 | 76155 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOPAR Fits: 6.4L V8 | 68322663AB | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1 | View on Amazon |
This table covers the fan assemblies (and clutches, where listed) that pull air through the radiator.
2 Radiator Fan Assembly parts are listed for the 2021 Ram 4500, from FOUR SEASONS and MOPAR.
Part numbers include FOUR SEASONS 76155 and MOPAR 68322663AB.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.4L V8 | 620057 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.4L V8 | 2812305 | 🇺🇸 US 🇨🇦 CA | Fan Blades Only | View on Amazon |
| MOPAR Fits: 6.4L V8 | 55056947AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1or Heavy Duty HEMI MDS Engine | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359841AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
4 Radiator Fan Blade parts are listed for the 2021 Ram 4500, from MOPAR, DORMAN and GPD.
This group includes DORMAN 620057, GPD 2812305 and MOPAR 55056947AA and the remaining parts above.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Popular Fits: 6.4L V8 | 46111 | 🇺🇸 US 🇨🇦 CA | Heavy Duty Thermal | View on Amazon |
| FOUR SEASONS Popular Fits: 6.7L L6 DIESEL Turbocharged | 46155 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| HAYDEN Popular Fits: 6.4L V8 | 2962 | 🇺🇸 US 🇨🇦 CA | ThermalHeavy Duty | View on Amazon |
| HAYDEN Popular Fits: 6.7L L6 DIESEL Turbocharged | 3400 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| FVP Fits: 6.7L L6 DIESEL Turbocharged | 9202690 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 6.4L V8 | 9202500 | 🇺🇸 US 🇨🇦 CA | Severe Duty | View on Amazon |
| GMB Fits: 6.7L L6 DIESEL Turbocharged | 9202690 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 6.4L V8 | 2911381 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOPAR Fits: 6.4L V8 | 68194962AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1or Heavy Duty HEMI MDS Engine | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359842AD | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| SKP Fits: 6.4L V8 | SK46111 | 🇺🇸 US 🇨🇦 CA | Heavy Duty Thermal | View on Amazon |
| US MOTOR WORKS Fits: 6.7L L6 DIESEL Turbocharged | 22354 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
12 Radiator Fan Clutch parts for the 2021 Ram 4500 come from 8 brands — FOUR SEASONS, HAYDEN, GMB and 5 other brands. The "Popular" part is FOUR SEASONS 46111.
Radiator Fan Clutch Bearing Bracket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Fits: 6.7L L6 DIESEL Turbocharged | FB1022 | 🇺🇸 US 🇨🇦 CA | Fan Pulley Bracket | View on Amazon |
This table covers the brackets that mount the Radiator Fan Clutch Bearing. Typical signs include a cracked mount, a rattle, or a bracket that no longer holds alignment. Confirm position in the notes. Many brackets look alike and bolt to different corners.
This group shows a single part: GATES FB1022.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.4L V8 | 620989 | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
| GPD Fits: 6.4L V8 | 2812378 | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68194960AC | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Regular Cab Chassis Wheelbase 3or Heavy Duty HEMI MDS Engine. | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68359839AB | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Regular Cab Chassis Wheelbase 3or Heavy Duty HEMI MDS Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359840AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68322504AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68322505AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
7 Radiator Fan Shroud parts for the 2021 Ram 4500 come from 3 brands — MOPAR, DORMAN and GPD.
Part numbers include DORMAN 620989, GPD 2812378 and MOPAR 68194960AC, among others listed above.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Popular Fits: 6.4L V8 | 68359610AD | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineInlet | View on Amazon |
| GATES Fits: 6.4L V8 | 52106 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GATES Fits: 6.4L V8 | 52108 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GATES Fits: 6.4L V8 | 52107 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68359796AF | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineOutlet | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359638AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Outlet | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359600AE | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Inlet | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359598AE | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Inlet | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
8 Radiator Hose parts are listed for the 2021 Ram 4500, from MOPAR and GATES. MOPAR 68359610AD carries the "Popular" badge.
This group includes MOPAR 68359610AD, GATES 52106 and GATES 52108 and the remaining parts above.
Radiator Mount Bushing
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: all 2021 4500 engines | 68050200AA | 🇺🇸 US 🇨🇦 CA | Lower | View on Amazon |
| MOPAR Fits: all 2021 4500 engines | 68451118AA | 🇺🇸 US 🇨🇦 CA | Upper | View on Amazon |
This table covers the Radiator Mount bushings. Typical signs include a clunk over bumps, or a torn or walked-out bushing you can see. Press the new bushing square. A cocked bushing will tear in a few thousand miles.
MOPAR supplies both parts for the 2021 Ram 4500. All of them fit every engine offered in the 2021 4500.
Part numbers include MOPAR 68050200AA and MOPAR 68451118AA.
Radiator Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: all 2021 4500 engines | 68362572AB | 🇺🇸 US 🇨🇦 CA | Fits RightHeavy Duty HEMI MDS Engine | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68362573AB | 🇺🇸 US 🇨🇦 CA | Fits LeftHeavy Duty HEMI MDS Engine | View on Amazon |
| MOPAR Fits: 6.4L V8 | 68359232AB | 🇺🇸 US 🇨🇦 CA | Radiat | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68359303AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68362560AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68362561AB | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.Regular Cab Chassis Wheelbase 3or Cummins Engine. | View on Amazon |
This table covers the seals at the Radiator. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
MOPAR supplies the 6 Radiator Seal parts for the 2021 Ram 4500. 1 part fits every engine; the other 5 are engine-specific.
Listed part numbers: MOPAR 68362572AB, MOPAR 68362573AB and MOPAR 68359232AB, plus the other parts above.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.4L V8 | 926427 | 🇺🇸 US 🇨🇦 CA | Thread Size: 3/8" | View on Amazon |
| GPD Fits: 6.4L V8 | 1712493 | 🇺🇸 US 🇨🇦 CA | with .38"-18" NPTwith 2 Terminal(s) | View on Amazon |
| GPD Fits: 6.7L L6 DIESEL Turbocharged | 1712596 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: 6.4L V8 | 2CTS0247 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS Fits: 6.4L V8 | TX195T | 🇺🇸 US 🇨🇦 CA | T-Series | View on Amazon |
| STANDARD MOTOR PRODUCTS Fits: 6.7L L6 DIESEL Turbocharged | TX141T | 🇺🇸 US 🇨🇦 CA | T-Series | View on Amazon |
| VEMO Fits: 6.7L L6 DIESEL Turbocharged | V33720251 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Full Service Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| WALKER PRODUCTS Fits: 6.7L L6 DIESEL Turbocharged | 21191050 | 🇺🇸 US 🇨🇦 CA | Full Service KitIncludes O-Ring | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DELPHI Popular Fits: 6.4L V8 | TS10330 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| NTK Popular Fits: 6.4L V8 | EF0034 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS Popular Fits: 6.4L V8 | TX195 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS Popular Fits: 6.7L L6 DIESEL Turbocharged | TX141 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| WALKER PRODUCTS Popular Fits: 6.7L L6 DIESEL Turbocharged | 2111050 | 🇺🇸 US 🇨🇦 CA | Sender Only or Sensor OnlyIncludes O-Ring | View on Amazon |
| BECK/ARNLEY Fits: 6.4L V8 | 1581735 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOPAR Fits: 6.4L V8 | 5149077AB | 🇺🇸 US 🇨🇦 CA | Fluid Temperature Sensor | View on Amazon |
| WALKER PRODUCTS Fits: 6.4L V8 | 2111130 | 🇺🇸 US 🇨🇦 CA | Sensor Only | View on Amazon |
| WELLS Fits: 6.4L V8 | 5S12397 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Rectangular | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
17 Temperature Sender / Sensor parts for the 2021 Ram 4500 come from 11 brands — STANDARD MOTOR PRODUCTS, WALKER PRODUCTS, GPD and 8 other brands. The "Popular" part is DELPHI TS10330.
The Economy section: 7 options from GPD, STANDARD MOTOR PRODUCTS, DORMAN and 2 other brands. DORMAN 926427 is listed in this group.
The Full Service Kit section lists 1 option from WALKER PRODUCTS — grouped under the catalog's "Full Service Kit" designation — the notes column spells out what sets them apart. WALKER PRODUCTS 21191050 is listed in this group.
Standard Replacement: 9 parts, from STANDARD MOTOR PRODUCTS, WALKER PRODUCTS, DELPHI and 4 other brands. A representative part number is DELPHI TS10330.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 6.4L V8 | 9023045 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and Sensor | View on Amazon |
| SKP Fits: 6.7L L6 DIESEL Turbocharged | SK5426190 | 🇺🇸 US 🇨🇦 CA | Includes Housing & Seal | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Popular Fits: 6.7L L6 DIESEL Turbocharged | 5426190 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 6.7L L6 DIESEL Turbocharged | 7426190 | 🇺🇸 US 🇨🇦 CA | Fail-SafeIncludes seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Popular Fits: 6.7L L6 DIESEL Turbocharged | 426190 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| CALORSTAT Fits: all 2021 4500 engines | TH713082J | 🇺🇸 US 🇨🇦 CA | PerformanceIncludes 1 Rubber Gasket | View on Amazon |
| FOUR SEASONS Fits: 6.4L V8 | 86260 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| GATES Fits: 6.7L L6 DIESEL Turbocharged | 33915 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
| MAHLE / CLEVITE Fits: 6.7L L6 DIESEL Turbocharged | TX50488D | 🇺🇸 US 🇨🇦 CA | Integral Thermostat | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68534176AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.50 State Emissions, with Emergency Vehicle Emissions | View on Amazon |
| MOTORAD Fits: 6.7L L6 DIESEL Turbocharged | 426180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
11 Thermostat parts are listed for the 2021 Ram 4500, from MOTORAD, DORMAN, SKP and 5 other brands. MOTORAD 5426190 carries the "Popular" badge. 1 part fits every engine; the other 10 are engine-specific.
Economy: 2 parts, from DORMAN and SKP. A representative part number is DORMAN 9023045.
The Heavy Duty section: 1 option from MOTORAD. MOTORAD 5426190 is listed in this group.
The Premium section: 1 option from MOTORAD. MOTORAD 7426190 is listed in this group.
The Standard Replacement section: 7 options from MOTORAD, CALORSTAT, FOUR SEASONS and 3 other brands. MOTORAD 426190 is listed in this group.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.7L L6 DIESEL Turbocharged | 35703 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 6.7L L6 DIESEL Turbocharged | C31858 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 5086740AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.50 State Emissions, with Emergency Vehicle Emissions | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
3 Thermostat / Thermostat Housing / Water Outlet Seal parts for the 2021 Ram 4500 come from 3 brands — FEL-PRO, MAHLE / CLEVITE and MOPAR.
This group includes FEL-PRO 35703, MAHLE / CLEVITE C31858 and MOPAR 5086740AA.
Thermostat Housing / Water Outlet
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: 6.4L V8 | 4893177AD | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Regular Cab Chassis Wheelbase 3or Heavy Duty HEMI MDS Engine. | View on Amazon |
| MOTORAD Fits: 6.4L V8 | 956216 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat, Housing, and Seal | View on Amazon |
| MOTORAD Fits: 6.7L L6 DIESEL Turbocharged | CH1073 | 🇺🇸 US 🇨🇦 CA | UpperThermostat Housing | View on Amazon |
| MOTORAD Fits: 6.7L L6 DIESEL Turbocharged | CH3092 | 🇺🇸 US 🇨🇦 CA | Fits LowerThermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
4 Thermostat Housing / Water Outlet parts are listed for the 2021 Ram 4500, from MOTORAD and MOPAR.
Part numbers include MOPAR 4893177AD, MOTORAD 956216 and MOTORAD CH1073, among others listed above.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Popular Fits: 6.4L V8 | SK1204540 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS Popular Fits: 6.4L V8 | US8140 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 6.4L V8 | US8140 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 6.7L L6 DIESEL Turbocharged | US99 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS Fits: 6.7L L6 DIESEL Turbocharged | US99 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular Fits: 6.7L L6 DIESEL Turbocharged | 42271 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| DAYCO Fits: 6.4L V8 | DP2165 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 6.7L L6 DIESEL Turbocharged | 1204050 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GATES Fits: 6.4L V8 | 43567 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 6.4L V8 | 1204540 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 6.7L L6 DIESEL Turbocharged | 1204050 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOPAR Fits: 6.4L V8 | 4893133AD | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS EngineRegular Cab Chassis Wheelbase 1or Heavy Duty HEMI MDS Engine | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
12 Water Pump parts are listed for the 2021 Ram 4500, from FVP, US MOTOR WORKS, GATES and 4 other brands. SKP SK1204540 carries the "Popular" badge.
Economy: 5 parts, from US MOTOR WORKS, FVP and SKP. A representative part number is SKP SK1204540.
The Standard Replacement section: 7 options from GATES, GMB, DAYCO and 2 other brands. GATES 42271 is listed in this group.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 6.7L L6 DIESEL Turbocharged | 35525 | 🇺🇸 US 🇨🇦 CA | To Block | View on Amazon |
| MAHLE / CLEVITE Fits: 6.4L V8 | K33718 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| MAHLE / CLEVITE Fits: 6.7L L6 DIESEL Turbocharged | K31420 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| MOPAR Fits: 6.4L V8 | 4893149AA | 🇺🇸 US 🇨🇦 CA | Fits Heavy Duty HEMI MDS Engine.Regular Cab Chassis Wheelbase 3or Heavy Duty HEMI MDS Engine. | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
4 Water Pump Gasket parts for the 2021 Ram 4500 come from 3 brands — MAHLE / CLEVITE, FEL-PRO and MOPAR.
Listed part numbers: FEL-PRO 35525, MAHLE / CLEVITE K33718 and MAHLE / CLEVITE K31420, plus the other parts above.
Water Pump Housing
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOPAR Fits: 6.7L L6 DIESEL Turbocharged | 68445172AA | 🇺🇸 US 🇨🇦 CA | Fits Cummins Engine.50 State Emissions, with Emergency Vehicle Emissions | View on Amazon |
This table covers the Water Pump housings.
This group shows a single part: MOPAR 68445172AA.
Buying Cooling System Parts for a 2021 Ram 4500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Temperature Sender / Sensor and Radiator Fan Clutch .
Frequently Asked Questions
How many cooling system parts fit the 2021 Ram 4500?
Our catalog currently lists 153 cooling system parts for the 2021 Ram 4500 across 27 subcategories and 29 brands, covering both the 6.4L V8 and the 6.7L L6 DIESEL Turbocharged. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2021 Ram 4500 engines?
Some do. 16 parts fit every engine; the other 137 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2021 Ram 4500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ram 4500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Ram 4500?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Ram 4500
Cooling System Parts for Other Ram 4500 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.