The 2021 Ford E-350 has 66 cooling system parts with verified fitment on this page — 17 part types and 23 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.
The cooling system system on the 2021 Ford E-350 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (14 parts), Radiator (7 parts) and Thermostat / Thermostat Housing / Water Outlet Seal (7 parts). The other 14 part types cover the remaining 38 parts.
Every part on this page is matched to the 7.3L V8 — the only engine offered in the 2021 Ford E-350.
The most listed brands for 2021 Ford E-350 cooling system parts are MOTORCRAFT (14 parts), MOTORAD (7 parts) and PRESTONE (6 parts), plus 20 more brands. Quality grades include Standard Replacement, Economy and Premium.
12 parts on this 2021 Ford E-350 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including PRESTONE AF3100 (Coolant / Antifreeze) and MOTORCRAFT RS527 (Coolant Reservoir Cap). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| PEAK | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| VALVOLINE | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
| VALVOLINE | 846439 | 🇺🇸 US 🇨🇦 CA | HD Nitrite Free Extended Life Yellow1 Gallon | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK | PXA1GAL | 🇺🇸 US 🇨🇦 CA | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE | AF6800 | 🇺🇸 US 🇨🇦 CA | MAX Original Equipment Antifreeze Coolant. American ORANGE 50/50 RTU 1 GAL | View on Amazon |
| PRESTONE | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | VC13G | 🇺🇸 US 🇨🇦 CA | Yellow Antifreeze / CoolantGallon | View on Amazon |
| AISIN | ACD006 | 🇺🇸 US 🇨🇦 CA | YellowHOAT | View on Amazon |
| MOTORCRAFT | VC13DLD | 🇺🇸 US 🇨🇦 CA | Yellow Antifreeze / Coolant55 Gallon Drum | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
14 Coolant / Antifreeze parts for the 2021 Ford E-350 come from 5 brands — PRESTONE, PEAK, VALVOLINE and 2 other brands. The "Popular" part is PRESTONE AF3100.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 3 options from PRESTONE, PEAK and VALVOLINE — the catalog's value-priced group. PRESTONE AF3100 is listed in this group.
In the Heavy Duty grade, PRESTONE and VALVOLINE supply 2 parts: rated for severe service. A representative part number is PRESTONE AFC12100.
In the Premium grade, PRESTONE and PEAK supply 5 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, MOTORCRAFT and AISIN supply 3 parts: built to original-equipment specification. A representative part number is MOTORCRAFT VC13G.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT | KM6936 | 🇺🇸 US 🇨🇦 CA | Hose - Supply Tank To RadiatorOverflow | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
This group shows a single part: MOTORCRAFT KM6936.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE | GS34033 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2021 Ford E-350 — MAHLE / CLEVITE GS34033.
Coolant Hose Connector / Flange Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING | 062220 | 🇺🇸 US 🇨🇦 CA | Water PumpStripped Chassis | View on Amazon |
This table covers the seals at the Coolant Hose Connector / Flange. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2021 Ford E-350 — ELRING 062220.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | RS527 | 🇺🇸 US 🇨🇦 CA | Threadedwith Pressure Relief Valve | View on Amazon |
| CALORSTAT | RC0159 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 16.0 PS | View on Amazon |
| DORMAN | 54208 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 16 PS | View on Amazon |
| GATES | 31406 | 🇺🇸 US 🇨🇦 CA | OE TypeThreaded Coolant Bottle Cap (Closed System) - (SAE Range 14-18 psi) | View on Amazon |
| MOTORAD | T38 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
5 Coolant Reservoir Cap parts are listed for the 2021 Ford E-350, from MOTORCRAFT, CALORSTAT, DORMAN and 2 other brands. MOTORCRAFT RS527 carries the "Popular" badge.
Part numbers include MOTORCRAFT RS527, CALORSTAT RC0159 and DORMAN 54208, among others listed above.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Popular | 13717 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD | 13917C | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP | RAD13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOTORCRAFT | RAD164 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| OSC | 13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TYC | 13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UAC | RA13917C | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
7 Radiator parts for the 2021 Ford E-350 come from 6 brands — GPD, FVP, MOTORCRAFT and 3 other brands. The "Popular" part is GPD 13717.
The Economy section: 2 options from GPD. GPD 13717 is listed in this group.
Standard Replacement: 5 parts, from FVP, MOTORCRAFT, OSC and 2 other brands. A representative part number is FVP RAD13917.
This group includes GPD 13717, GPD 13917C and FVP RAD13917 and the remaining parts above.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT | YA274 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
One part is listed for the 2021 Ford E-350 — MOTORCRAFT YA274.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Popular | 46153 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| HAYDEN Popular | 3250 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| FVP | 22353 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOTORCRAFT | YB3283 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SKP | SK12883 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| US MOTOR WORKS | 22353 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
6 Radiator Fan Clutch parts for the 2021 Ford E-350 come from 6 brands — FOUR SEASONS, HAYDEN, FVP and 3 other brands. The "Popular" part is FOUR SEASONS 46153.
Part numbers include FOUR SEASONS 46153, HAYDEN 3250 and FVP 22353, among others listed above.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES | 52475 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| MOTORCRAFT | KM6934 | 🇺🇸 US 🇨🇦 CA | Upper | View on Amazon |
| MOTORCRAFT | KM7023 | 🇺🇸 US 🇨🇦 CA | LowerRadiator / Coolant Overflow Container | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
3 Radiator Hose parts are listed for the 2021 Ford E-350, from MOTORCRAFT and GATES.
This group includes GATES 52475, MOTORCRAFT KM6934 and MOTORCRAFT KM7023.
Radiator Mount Bushing
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 927244 | 🇺🇸 US 🇨🇦 CA | Fits Right Lower | View on Amazon |
This table covers the Radiator Mount bushings. Typical signs include a clunk over bumps, or a torn or walked-out bushing you can see. Press the new bushing square. A cocked bushing will tear in a few thousand miles.
One part is listed for the 2021 Ford E-350 — DORMAN 927244.
Temperature Sender / Sensor
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD | 1814526 | 🇺🇸 US 🇨🇦 CA | IN CYLINDER HEAD | View on Amazon |
| HOLSTEIN | 2CTS0297 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
2 Temperature Sender / Sensor parts for the 2021 Ford E-350 come from 2 brands — GPD and HOLSTEIN.
Part numbers include GPD 1814526 and HOLSTEIN 2CTS0297.
Thermostat
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD | MRD109 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | RT1247 | 🇺🇸 US 🇨🇦 CA | 190 Degree Thermostat | View on Amazon |
| MOTORAD | 1121192 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD | 1121160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD | 2080KT | 🇺🇸 US 🇨🇦 CA | Includes Housing and SealKit | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
5 Thermostat parts are listed for the 2021 Ford E-350, from MOTORAD and MOTORCRAFT. MOTORCRAFT RT1247 carries the "Popular" badge.
In the Performance grade, MOTORAD supplies 1 part: engineered beyond original-equipment specification. A representative part number is MOTORAD MRD109.
The Standard Replacement section: 4 options from MOTORAD and MOTORCRAFT. MOTORCRAFT RT1247 is listed in this group.
This group includes MOTORCRAFT RT1247, MOTORAD MRD109 and MOTORAD 1121192 and the remaining parts above.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular | 33671 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal - 1 63/64" x 2 17/64" x 9/64" (O-Ring) | View on Amazon |
| MOTORCRAFT Popular | RG571 | 🇺🇸 US 🇨🇦 CA | Water Outlet Seal | View on Amazon |
| CALORSTAT | J119 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| FEL-PRO | 35489 | 🇺🇸 US 🇨🇦 CA | Outside Diameter: 51.5 mm | View on Amazon |
| MAHLE / CLEVITE | C31302 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
| MOTORAD | MG90 | 🇺🇸 US 🇨🇦 CA | Style: O-Ring | View on Amazon |
| MOTORCRAFT | RG654 | 🇺🇸 US 🇨🇦 CA | To Thermostat Housing | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
7 Thermostat / Thermostat Housing / Water Outlet Seal parts for the 2021 Ford E-350 come from 6 brands — MOTORCRAFT, GATES, CALORSTAT and 3 other brands. The "Popular" part is GATES 33671.
This group includes GATES 33671, MOTORCRAFT RG571 and CALORSTAT J119 and the remaining parts above.
Thermostat Housing / Water Outlet
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD | CH2080 | 🇺🇸 US 🇨🇦 CA | Fits Thermostat Housingor Water Outlet | View on Amazon |
| MOTORCRAFT | RH286 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
2 Thermostat Housing / Water Outlet parts are listed for the 2021 Ford E-350, from MOTORAD and MOTORCRAFT.
Listed part numbers: MOTORAD CH2080 and MOTORCRAFT RH286.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE | C33825 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
This group shows a single part: MAHLE / CLEVITE C33825.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Popular | SK1254040 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP | US8188 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS | US8188 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | PW629 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP | 1254040 | 🇺🇸 US 🇨🇦 CA | Water Pump Drive Type: Serpentine Belt | View on Amazon |
| GATES | 43187 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB | 1254040 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
7 Water Pump parts are listed for the 2021 Ford E-350, from FVP, SKP, US MOTOR WORKS and 3 other brands. SKP SK1254040 carries the "Popular" badge.
Economy: 3 parts, from SKP, FVP and US MOTOR WORKS. A representative part number is SKP SK1254040.
The Standard Replacement section: 4 options from MOTORCRAFT, FVP, GATES and 1 other brand. MOTORCRAFT PW629 is listed in this group.
This group includes SKP SK1254040 and FVP US8188 and the remaining parts above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING | 062100 | 🇺🇸 US 🇨🇦 CA | Stripped ChassisBody code: E3F | View on Amazon |
| MAHLE / CLEVITE | K33826 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
2 Water Pump Gasket parts for the 2021 Ford E-350 come from 2 brands — ELRING and MAHLE / CLEVITE.
Part numbers include ELRING 062100 and MAHLE / CLEVITE K33826.
Buying Cooling System Parts for a 2021 Ford E-350
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Radiator .
Frequently Asked Questions
How many cooling system parts fit the 2021 Ford E-350?
Our catalog currently lists 66 cooling system parts for the 2021 Ford E-350 across 17 subcategories and 23 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of cooling system problems on a 2021 Ford E-350?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ford E-350 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Ford E-350?
Every part on this page is matched to the 7.3L V8 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Ford E-350
Cooling System Parts for Other Ford E-350 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.