2021 Ford E-350 Cooling System Parts

Engine:
7.3L V8

The 2021 Ford E-350 has 66 cooling system parts with verified fitment on this page — 17 part types and 23 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.

The cooling system system on the 2021 Ford E-350 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (14 parts), Radiator (7 parts) and Thermostat / Thermostat Housing / Water Outlet Seal (7 parts). The other 14 part types cover the remaining 38 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
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Economy

Brand Part Number Markets Notes Buy
PRESTONE Popular AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
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PEAK BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
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VALVOLINE 719009
🇺🇸 US 🇨🇦 CA
Multi-Vehicle Yellow1 Gallon
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Heavy Duty

Brand Part Number Markets Notes Buy
PRESTONE AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
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VALVOLINE 846439
🇺🇸 US 🇨🇦 CA
HD Nitrite Free Extended Life Yellow1 Gallon
Fitment notes — VALVOLINE 846439
HD Nitrite Free Extended Life Yellow1 GallonOAT
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Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
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PEAK PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
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PEAK PXA1GAL
🇺🇸 US 🇨🇦 CA
Global Lifetime1 Gallon
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PRESTONE AF6800
🇺🇸 US 🇨🇦 CA
MAX Original Equipment Antifreeze Coolant. American ORANGE 50/50 RTU 1 GAL
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PRESTONE AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
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Standard Replacement

Brand Part Number Markets Notes Buy
MOTORCRAFT Popular VC13G
🇺🇸 US 🇨🇦 CA
Yellow Antifreeze / CoolantGallon
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AISIN ACD006
🇺🇸 US 🇨🇦 CA
YellowHOAT
Fitment notes — AISIN ACD006
YellowHOAT
(Type: Prediluted)
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MOTORCRAFT VC13DLD
🇺🇸 US 🇨🇦 CA
Yellow Antifreeze / Coolant55 Gallon Drum
Fitment notes — MOTORCRAFT VC13DLD
Yellow Antifreeze / Coolant55 Gallon DrumFlash Point: 200
(Type: Prediluted)
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This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Hose / Pipe

Brand Part Number Markets Notes Buy
MOTORCRAFT KM6936
🇺🇸 US 🇨🇦 CA
Hose - Supply Tank To RadiatorOverflow
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This table covers the hard pipes and extra hoses in the coolant circuit.

Coolant Hose / Pipe Seal

Brand Part Number Markets Notes Buy
MAHLE / CLEVITE GS34033
🇺🇸 US 🇨🇦 CA
Engine Coolant Outlet O-RingMolded Rubber
Fitment notes — MAHLE / CLEVITE GS34033
Engine Coolant Outlet O-RingMolded Rubber
Heater Hose Outlet Tube O-Ring SetCoolant Pipe
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This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Coolant Hose Connector / Flange Seal

Brand Part Number Markets Notes Buy
ELRING 062220
🇺🇸 US 🇨🇦 CA
Water PumpStripped Chassis
Fitment notes — ELRING 062220
Water PumpStripped ChassisBody code: E3FInlet Flange Seal
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This table covers the seals at the Coolant Hose Connector / Flange. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
MOTORCRAFT Popular RS527
🇺🇸 US 🇨🇦 CA
Threadedwith Pressure Relief Valve
Fitment notes — MOTORCRAFT RS527
Threadedwith Pressure Relief ValveMaximum Pressure Rating of 16lbs
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CALORSTAT RC0159
🇺🇸 US 🇨🇦 CA
Maximum Pressure Rating: 16.0 PS
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DORMAN 54208
🇺🇸 US 🇨🇦 CA
Maximum Pressure Rating: 16 PS
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GATES 31406
🇺🇸 US 🇨🇦 CA
OE TypeThreaded Coolant Bottle Cap (Closed System) - (SAE Range 14-18 psi)
Fitment notes — GATES 31406
OE TypeThreaded Coolant Bottle Cap (Closed System) - (SAE Range 14-18 psi)
16 psi Pressure Rating
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MOTORAD T38
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T38
Standard
Relief Pressure 16 lbs
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This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator

Economy

Brand Part Number Markets Notes Buy
GPD Popular 13717
🇺🇸 US 🇨🇦 CA
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GPD 13917C
🇺🇸 US 🇨🇦 CA
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Standard Replacement

Brand Part Number Markets Notes Buy
FVP RAD13917
🇺🇸 US 🇨🇦 CA
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MOTORCRAFT RAD164
🇺🇸 US 🇨🇦 CA
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OSC 13917
🇺🇸 US 🇨🇦 CA
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TYC 13917
🇺🇸 US 🇨🇦 CA
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UAC RA13917C
🇺🇸 US 🇨🇦 CA
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This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Fan Blade

Brand Part Number Markets Notes Buy
MOTORCRAFT YA274
🇺🇸 US 🇨🇦 CA
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This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
FOUR SEASONS Popular 46153
🇺🇸 US 🇨🇦 CA
Electronic
Fitment notes — FOUR SEASONS 46153
Electronic
Standard Rotation
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HAYDEN Popular 3250
🇺🇸 US 🇨🇦 CA
Electronic
Fitment notes — HAYDEN 3250
Electronic
Standard Rotation
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FVP 22353
🇺🇸 US 🇨🇦 CA
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MOTORCRAFT YB3283
🇺🇸 US 🇨🇦 CA
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SKP SK12883
🇺🇸 US 🇨🇦 CA
Electronic
Fitment notes — SKP SK12883
Electronic
Standard Rotation
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US MOTOR WORKS 22353
🇺🇸 US 🇨🇦 CA
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This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Hose

Brand Part Number Markets Notes Buy
GATES 52475
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 52475
Molded
Upper
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MOTORCRAFT KM6934
🇺🇸 US 🇨🇦 CA
Upper
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MOTORCRAFT KM7023
🇺🇸 US 🇨🇦 CA
LowerRadiator / Coolant Overflow Container
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This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Radiator Mount Bushing

Brand Part Number Markets Notes Buy
DORMAN 927244
🇺🇸 US 🇨🇦 CA
Fits Right Lower
Fitment notes — DORMAN 927244
Fits:
Right Lower
or:
Left Lower
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This table covers the Radiator Mount bushings. Typical signs include a clunk over bumps, or a torn or walked-out bushing you can see. Press the new bushing square. A cocked bushing will tear in a few thousand miles.

Temperature Sender / Sensor

Brand Part Number Markets Notes Buy
GPD 1814526
🇺🇸 US 🇨🇦 CA
IN CYLINDER HEAD
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HOLSTEIN 2CTS0297
🇺🇸 US 🇨🇦 CA
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This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Performance

Brand Part Number Markets Notes Buy
MOTORAD MRD109
🇺🇸 US 🇨🇦 CA
RacingIncludes Thermostat and Seal
Fitment notes — MOTORAD MRD109
RacingIncludes Thermostat and Seal
Temperature 160FAlternate Temperature Option
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Standard Replacement

Brand Part Number Markets Notes Buy
MOTORCRAFT Popular RT1247
🇺🇸 US 🇨🇦 CA
190 Degree Thermostat
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MOTORAD 1121192
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 1121192
Includes Seal
192 Degrees FOE Specified Temperature
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MOTORAD 1121160
🇺🇸 US 🇨🇦 CA
Includes Seal
Fitment notes — MOTORAD 1121160
Includes Seal
160 Degrees FAlternate Temperature Option
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MOTORAD 2080KT
🇺🇸 US 🇨🇦 CA
Includes Housing and SealKit
Fitment notes — MOTORAD 2080KT
Includes Housing and SealKit
192 Degrees FOE Specified Temperature
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This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
GATES Popular 33671
🇺🇸 US 🇨🇦 CA
Thermostat Seal - 1 63/64" x 2 17/64" x 9/64" (O-Ring)
Fitment notes — GATES 33671
Thermostat Seal - 1 63/64" x 2 17/64" x 9/64" (O-Ring)
Thermostat Seal
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MOTORCRAFT Popular RG571
🇺🇸 US 🇨🇦 CA
Water Outlet Seal
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CALORSTAT J119
🇺🇸 US 🇨🇦 CA
Thermostat Seal
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FEL-PRO 35489
🇺🇸 US 🇨🇦 CA
Outside Diameter: 51.5 mm
Fitment notes — FEL-PRO 35489
Outside Diameter: 51.5 mm
Thermostat Seal
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MAHLE / CLEVITE C31302
🇺🇸 US 🇨🇦 CA
Engine Coolant Outlet O-RingMolded Rubber
Fitment notes — MAHLE / CLEVITE C31302
Engine Coolant Outlet O-RingMolded Rubber
Thermostat O-RingThermostat Housing Seal
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MOTORAD MG90
🇺🇸 US 🇨🇦 CA
Style: O-Ring
Fitment notes — MOTORAD MG90
Style: O-Ring
Thermostat Seal
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MOTORCRAFT RG654
🇺🇸 US 🇨🇦 CA
To Thermostat Housing
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This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Thermostat Housing / Water Outlet

Brand Part Number Markets Notes Buy
MOTORAD CH2080
🇺🇸 US 🇨🇦 CA
Fits Thermostat Housingor Water Outlet
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MOTORCRAFT RH286
🇺🇸 US 🇨🇦 CA
Thermostat Housing
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This table covers the housings and outlets the thermostat sits in.

Water Inlet Gasket

Brand Part Number Markets Notes Buy
MAHLE / CLEVITE C33825
🇺🇸 US 🇨🇦 CA
Molded Rubber
Fitment notes — MAHLE / CLEVITE C33825
Molded Rubber
Coolant Inlet Tube
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This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump

Economy

Brand Part Number Markets Notes Buy
SKP Popular SK1254040
🇺🇸 US 🇨🇦 CA
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FVP US8188
🇺🇸 US 🇨🇦 CA
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US MOTOR WORKS US8188
🇺🇸 US 🇨🇦 CA
View on
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Standard Replacement

Brand Part Number Markets Notes Buy
MOTORCRAFT Popular PW629
🇺🇸 US 🇨🇦 CA
View on
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FVP 1254040
🇺🇸 US 🇨🇦 CA
Water Pump Drive Type: Serpentine Belt
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GATES 43187
🇺🇸 US 🇨🇦 CA
View on
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GMB 1254040
🇺🇸 US 🇨🇦 CA
View on
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This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Water Pump Gasket

Brand Part Number Markets Notes Buy
ELRING 062100
🇺🇸 US 🇨🇦 CA
Stripped ChassisBody code: E3F
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MAHLE / CLEVITE K33826
🇺🇸 US 🇨🇦 CA
Molded Rubber
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This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Buying Cooling System Parts for a 2021 Ford E-350

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Coolant / Antifreeze and Radiator .

Frequently Asked Questions

How many cooling system parts fit the 2021 Ford E-350?

Our catalog currently lists 66 cooling system parts for the 2021 Ford E-350 across 17 subcategories and 23 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.

What are the signs of cooling system problems on a 2021 Ford E-350?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ford E-350 was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2021 Ford E-350?

Every part on this page is matched to the 7.3L V8 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2021 Ford E-350

Cooling System Parts for Other Ford E-350 Years

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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.