The 2021 Ford E-350 has 84 drivetrain parts with verified fitment on this page — 18 part types and 19 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.
On the 2021 Ford E-350, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. Most of the listed parts are Universal Joint (33 parts), Gear Oil (12 parts) and Axle Shaft (8 parts). The other 15 part types cover the remaining 31 parts.
The 2021 Ford E-350 came with a single engine, the 7.3L V8, and every part is verified against it.
19 brands supply drivetrain parts for the 2021 Ford E-350, led by DANA (28 parts), VALVOLINE (10 parts) and SKF (8 parts), plus 16 more brands. Quality grades include Standard Replacement, Heavy Duty and Economy.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 Ford E-350. 12 parts have it, including DANA 438117 (Axle Shaft) and DANA 211359X (Drive Shaft Center Support Bearing). Each part number opens a page with every vehicle that part fits.
Axle Shaft
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA Popular | 438117 | 🇺🇸 US 🇨🇦 CA | SpicerLength: 40.75 | View on Amazon |
| DANA Popular | 760022X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 34.08 | View on Amazon |
| DANA | 438114 | 🇺🇸 US 🇨🇦 CA | SpicerLength: 37.40 | View on Amazon |
| DANA | 753441X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 31.41 | View on Amazon |
| DANA | 753442X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 34.13 | View on Amazon |
| DANA | 760021X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 31.36 | View on Amazon |
| MOTIVE GEAR | 753441XR | 🇺🇸 US 🇨🇦 CA | Rear RightDana 60 Standard Differential | View on Amazon |
| MOTIVE GEAR | 753442XR | 🇺🇸 US 🇨🇦 CA | Rear LeftDana 60 Standard Differential | View on Amazon |
This table covers the Axle shafts.
8 Axle Shaft parts for the 2021 Ford E-350 come from 2 brands — DANA and MOTIVE GEAR. The "Popular" part is DANA 438117.
This group includes DANA 438117, DANA 760022X and DANA 438114 and the remaining parts above.
Axle Shaft Flange Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 926880 | 🇺🇸 US 🇨🇦 CA | RearOver 7,700 Lb. GVW | View on Amazon |
This table covers the gaskets that seal the Axle Shaft Flange. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
This group shows a single part: DORMAN 926880.
Differential Carrier
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7072161X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 2005750 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 7072121X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 7080761 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the carriers that hold the differential gears in the axle.
DANA supplies the 4 Differential Carrier parts for the 2021 Ford E-350.
Listed part numbers: DANA 7072161X, DANA 2005750 and DANA 7072121X, plus the other parts above.
Differential Carrier Bearing / Race
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 566079 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 566080 | 🇺🇸 US 🇨🇦 CA | FSGRRace | View on Amazon |
This table covers the bearings and races that support the differential carrier.
DANA supplies both parts for the 2021 Ford E-350.
Listed part numbers: DANA 566079 and DANA 566080.
Differential Cover
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7071051X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 20065041 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Differential covers.
2 Differential Cover parts for the 2021 Ford E-350 come from DANA.
Part numbers include DANA 7071051X and DANA 20065041.
Differential Pinion Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 2010948 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the flanges that connect the driveshaft to the differential pinion.
One part is listed for the 2021 Ford E-350 — DANA 2010948.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 50637 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| SCHAEFFLER | SS2923 | 🇺🇸 US 🇨🇦 CA | Rear Outer3.21" O.D. X 0.5" Width | View on Amazon |
| TIMKEN | 100715V | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
3 Differential Pinion Seal parts are listed for the 2021 Ford E-350, from DANA, SCHAEFFLER and TIMKEN.
This group includes DANA 50637, SCHAEFFLER SS2923 and TIMKEN 100715V.
Differential Rebuild Kit
Master Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BCA | NBDRK332AMK | 🇺🇸 US 🇨🇦 CA | Master Kit | View on Amazon |
Standard Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BCA | NBDRK332A | 🇺🇸 US 🇨🇦 CA | Standard Kit | View on Amazon |
| BCA | NBRA332HD | 🇺🇸 US 🇨🇦 CA | Standard Kit | View on Amazon |
| LUK | GDK332HD | 🇺🇸 US 🇨🇦 CA | Standard Kit | View on Amazon |
This table covers kits that group the bearings, races and seals for a differential rebuild.
4 Differential Rebuild Kit parts for the 2021 Ford E-350 come from 2 brands — BCA and LUK.
The Master Kit section lists 1 option from BCA — grouped under the catalog's "Master Kit" designation — the notes column spells out what sets them apart. BCA NBDRK332AMK is listed in this group.
In the Standard Kit grade, BCA and LUK supply 3 parts: grouped under the catalog's "Standard Kit" designation — the notes column spells out what sets them apart. A representative part number is BCA NBDRK332A.
Listed part numbers: BCA NBDRK332AMK, BCA NBDRK332A and BCA NBRA332HD, plus the other parts above.
Differential Ring and Pinion
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7081256 | 🇺🇸 US 🇨🇦 CA | Includes Pinion Bearings, Seals, and Ring Gear Bolts | View on Amazon |
| DANA | 760885X | 🇺🇸 US 🇨🇦 CA | SpicerIncludes Ring Gear Bolts, Pinion Nut, & Crush Sleeve | View on Amazon |
This table covers the ring-and-pinion gear sets that set the axle ratio.
DANA supplies both parts for the 2021 Ford E-350.
This group includes DANA 7081256 and DANA 760885X.
Differential Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING | B16160 | 🇺🇸 US 🇨🇦 CA | Height [MM]: 16Outer Diameter 2 [MM]: 92 | View on Amazon |
This table covers the seals at the Differential. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
This group shows a single part: ELRING B16160.
Differential Spider Gear
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 707252X | 🇺🇸 US 🇨🇦 CA | FSGRCarrier Gear Kit | View on Amazon |
This table covers the Differential Spider gears.
One part is listed for the 2021 Ford E-350 — DANA 707252X.
Drive Shaft
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 966402 | 🇺🇸 US 🇨🇦 CA | Length: 72.25" | View on Amazon |
| WJB / INMOTION PARTS | WDS66402 | 🇺🇸 US 🇨🇦 CA | Rear138.0" Wheelbase | View on Amazon |
This table covers the driveshafts that carry torque from the transmission or transfer case.
2 Drive Shaft parts for the 2021 Ford E-350 come from 2 brands — DORMAN and WJB / INMOTION PARTS.
This group includes DORMAN 966402 and WJB / INMOTION PARTS WDS66402.
Drive Shaft Bolt
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 80992 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the Drive Shaft bolts.
One part is listed for the 2021 Ford E-350 — DORMAN 80992.
Drive Shaft Center Support Bearing
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DEA / MARMON RIDE CONTROL | A60079 | 🇺🇸 US 🇨🇦 CA | MRC Driveline | View on Amazon |
| DORMAN | 934007 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA Popular | 211359X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| ANCHOR | 6053 | 🇺🇸 US 🇨🇦 CA | Centerwithout Mounting Studs | View on Amazon |
| DANA | 25211359X | 🇺🇸 US 🇨🇦 CA | Spicer Select | View on Amazon |
This table covers the Drive Shaft Center Support bearings. Typical signs include a growl that rises with speed, or play in the shaft or hub. Set preload the way the notes specify. A dry or crushed bearing fails quickly.
5 Drive Shaft Center Support Bearing parts for the 2021 Ford E-350 come from 4 brands — DANA, DEA / MARMON RIDE CONTROL, DORMAN and 1 other brand. The "Popular" part is DANA 211359X.
The Economy section lists 2 options from DEA / MARMON RIDE CONTROL and DORMAN — the catalog's value-priced group. DEA / MARMON RIDE CONTROL A60079 is listed in this group.
In the Standard Replacement grade, DANA and ANCHOR supply 3 parts: built to original-equipment specification. A representative part number is DANA 211359X.
This group includes DANA 211359X, DEA / MARMON RIDE CONTROL A60079 and DORMAN 934007 and the remaining parts above.
Drive Shaft Flange Yoke
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 321839 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Drive Shaft Flange yokes.
One part is listed for the 2021 Ford E-350 — DANA 321839.
Drive Shaft Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING | B19790 | 🇺🇸 US 🇨🇦 CA | Outer Diameter [MM]: 35,8 | View on Amazon |
This table covers the seals at the Drive Shaft. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
One part is listed for the 2021 Ford E-350 — ELRING B19790.
Gear Oil
SAE 75W-140
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VALVOLINE Popular | VV982 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil1 Quart | View on Amazon |
| MOBIL | 102490 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-14 0Mobil 1 Synthetic Gear Lubricant LS 75W-14 0 | View on Amazon |
| VALVOLINE | 889787 | 🇺🇸 US 🇨🇦 CA | Full Synthetic SAE 75W-14 0 Gear Oil1 Quart Flex Fill | View on Amazon |
| VALVOLINE | 887344 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE | VV981 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil5 Gallon | View on Amazon |
SAE 75W-90
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL Popular | 104361 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-901 Quart | View on Amazon |
| VALVOLINE Popular | VV975 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil1 Quart | View on Amazon |
| VALVOLINE | VV820 | 🇺🇸 US 🇨🇦 CA | Daily Protection SAE 75W-90 Gear Oil1 Quart | View on Amazon |
| VALVOLINE | 889785 | 🇺🇸 US 🇨🇦 CA | Full Synthetic SAE 75W-90 Gear Oil1 Quart Flex Fill | View on Amazon |
| VALVOLINE | 882505 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE | 723856 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil5 Gallon | View on Amazon |
| VALVOLINE | VV822 | 🇺🇸 US 🇨🇦 CA | Daily Protection SAE 75W-90 Gear Oil16 Gallon KEG | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
12 Gear Oil parts are listed for the 2021 Ford E-350, from VALVOLINE and MOBIL. VALVOLINE VV982 carries the "Popular" badge.
In the SAE 75W-140 grade, VALVOLINE and MOBIL supply 5 parts: grouped under the catalog's "SAE 75W-140" designation — the notes column spells out what sets them apart. A representative part number is VALVOLINE VV982.
In the SAE 75W-90 grade, VALVOLINE and MOBIL supply 7 parts: grouped under the catalog's "SAE 75W-90" designation — the notes column spells out what sets them apart. A representative part number is MOBIL 104361.
Universal Joint
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA Popular | 15160X | 🇺🇸 US 🇨🇦 CA | SVLGreasable | View on Amazon |
| DANA | 25160X | 🇺🇸 US 🇨🇦 CA | Spicer SelectGreasable | View on Amazon |
| WJB / INMOTION PARTS | UJT295 | 🇺🇸 US 🇨🇦 CA | Grade Type: Performance-Bearing Greaseable | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOOG Popular | 295 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
| ACDELCO | 45U0109 | 🇺🇸 US 🇨🇦 CA | Greasable Super Strength | View on Amazon |
| ACDELCO | 45U0123 | 🇺🇸 US 🇨🇦 CA | Non-Greasable Super Strength | View on Amazon |
| ACDELCO | 45U0304 | 🇺🇸 US 🇨🇦 CA | Greasable Super Strength | View on Amazon |
| DANA | 51410X | 🇺🇸 US 🇨🇦 CA | Spicer Life Series (SPL)Non-Greasable | View on Amazon |
| DANA | 51410XP | 🇺🇸 US 🇨🇦 CA | Spicer Life Series (SPL) PlusNon-Greasable | View on Amazon |
| DANA | 514101X | 🇺🇸 US 🇨🇦 CA | Spicer Life Series (SPL)Greasable | View on Amazon |
| GMB | 2150178 | 🇺🇸 US 🇨🇦 CA | Performance GradeGreasable | View on Amazon |
| MOOG | 231 | 🇺🇸 US 🇨🇦 CA | Super StrengthNon-Greasable | View on Amazon |
| MOOG | 232 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
| MOOG | 487 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
| MOOG | 238 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
| SKF | UJ231 | 🇺🇸 US 🇨🇦 CA | Brute Force Non Greaseable | View on Amazon |
| SKF | UJ232 | 🇺🇸 US 🇨🇦 CA | Brute Force Greaseable | View on Amazon |
| SKF | UJ295 | 🇺🇸 US 🇨🇦 CA | Brute Force Greaseable | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GMB Popular | 2100178 | 🇺🇸 US 🇨🇦 CA | GreasableGrease Fitting in Cross | View on Amazon |
| GMB Popular | 2100447 | 🇺🇸 US 🇨🇦 CA | Non-Greasable1.188" Bearing Cap Diameter | View on Amazon |
| MOOG Popular | 331 | 🇺🇸 US 🇨🇦 CA | Greasable | View on Amazon |
| MOOG Popular | 330 | 🇺🇸 US 🇨🇦 CA | Greasable | View on Amazon |
| AAM | 19256728 | 🇺🇸 US 🇨🇦 CA | Rear Shaftwith 1355 U-Joints | View on Amazon |
| ACDELCO | 45U0103 | 🇺🇸 US 🇨🇦 CA | Gold | View on Amazon |
| ACDELCO | 45U0300 | 🇺🇸 US 🇨🇦 CA | Gold | View on Amazon |
| DANA | 5160X | 🇺🇸 US 🇨🇦 CA | SpicerGreasable | View on Amazon |
| FVP | 2100447 | 🇺🇸 US 🇨🇦 CA | Non-Greasable1.188" Bearing Cap Diameter | View on Amazon |
| GMB | 2100160 | 🇺🇸 US 🇨🇦 CA | GreasableGrease Fitting In CROSS | View on Amazon |
| SKF | UJ33010 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ330 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ331 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ331C | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ330C | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
This table covers the U-joints in the driveshaft.
33 Universal Joint parts are listed for the 2021 Ford E-350, from SKF, MOOG, DANA and 5 other brands. DANA 15160X carries the "Popular" badge. Grades run from Economy through Standard Replacement; Heavy Duty is the most populated section, led by MOOG, ACDELCO, DANA and 2 other brands.
Buying Drivetrain Parts for a 2021 Ford E-350
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Universal Joint and Gear Oil .
Frequently Asked Questions
How many drivetrain parts fit the 2021 Ford E-350?
Our catalog currently lists 84 drivetrain parts for the 2021 Ford E-350 across 18 subcategories and 19 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2021 Ford E-350?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ford E-350 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Ford E-350?
Every part on this page is matched to the 7.3L V8 engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Ford E-350
Drivetrain Parts for Other Ford E-350 Years
Switch vehicle or jump to a subcategory
Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.