58 Cooling system parts are listed for the 2021 Ford E-450, in 15 part types, covering the 7.3L V8 engine. Each one has a brand, a manufacturer part number and notes that say where it fits.
The cooling system system on the 2021 Ford E-450 keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (14 parts), Water Pump (7 parts) and Radiator Fan Clutch (6 parts). The other 12 part types cover the remaining 31 parts.
The 2021 Ford E-450 came with a single engine, the 7.3L V8, and every part is verified against it.
19 brands supply cooling system parts for the 2021 Ford E-450, led by MOTORCRAFT (14 parts), MOTORAD (7 parts) and PRESTONE (5 parts), plus 16 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2021 Ford E-450. 10 parts have it, including PRESTONE AF2100 (Coolant / Antifreeze) and FOUR SEASONS 46153 (Radiator Fan Clutch). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PEAK | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
| VALVOLINE | 846439 | 🇺🇸 US 🇨🇦 CA | HD Nitrite Free Extended Life Yellow1 Gallon | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK | PXA1GAL | 🇺🇸 US 🇨🇦 CA | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | VC13G | 🇺🇸 US 🇨🇦 CA | Yellow Antifreeze / CoolantGallon | View on Amazon |
| VALVOLINE Popular | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| AISIN | ACD006 | 🇺🇸 US 🇨🇦 CA | YellowHOAT | View on Amazon |
| MOTORCRAFT | VC13DLD | 🇺🇸 US 🇨🇦 CA | Yellow Antifreeze / Coolant55 Gallon Drum | View on Amazon |
| VALVOLINE | 888374 | 🇺🇸 US 🇨🇦 CA | American Vehicle Orange1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
14 Coolant / Antifreeze parts are listed for the 2021 Ford E-450, from PRESTONE, PEAK, VALVOLINE and 2 other brands. PRESTONE AF2100 carries the "Popular" badge.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, PEAK and PRESTONE supply 2 parts: the catalog's value-priced group. A representative part number is PEAK BQA1GAL.
The Heavy Duty section lists 2 options from PRESTONE and VALVOLINE — rated for severe service. PRESTONE AFC12100 is listed in this group.
The Premium section lists 4 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 5 options from MOTORCRAFT, VALVOLINE and AISIN — built to original-equipment specification. MOTORCRAFT VC13G is listed in this group.
Coolant Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT | KM6936 | 🇺🇸 US 🇨🇦 CA | Hose - Supply Tank To RadiatorOverflow | View on Amazon |
This table covers the hard pipes and extra hoses in the coolant circuit.
One part is listed for the 2021 Ford E-450 — MOTORCRAFT KM6936.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE | GS34033 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
This group shows a single part: MAHLE / CLEVITE GS34033.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 54208 | 🇺🇸 US 🇨🇦 CA | Maximum Pressure Rating: 16 PS | View on Amazon |
| GATES | 31406 | 🇺🇸 US 🇨🇦 CA | OE TypeThreaded Coolant Bottle Cap (Closed System) - (SAE Range 14-18 psi) | View on Amazon |
| MOTORAD | T38 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
| MOTORCRAFT | RS527 | 🇺🇸 US 🇨🇦 CA | Threadedwith Pressure Relief Valve | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
4 Coolant Reservoir Cap parts for the 2021 Ford E-450 come from 4 brands — DORMAN, GATES, MOTORAD and 1 other brand.
This group includes DORMAN 54208, GATES 31406 and MOTORAD T38 and the remaining parts above.
Radiator
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP | RAD13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOTORCRAFT | RAD164 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| OSC | 13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| TYC | 13917 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UAC | RA13917C | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
5 Radiator parts are listed for the 2021 Ford E-450, from FVP, MOTORCRAFT, OSC and 2 other brands.
This group includes FVP RAD13917, MOTORCRAFT RAD164 and OSC 13917 and the remaining parts above.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT | YA274 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
This group shows a single part: MOTORCRAFT YA274.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FOUR SEASONS Popular | 46153 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| HAYDEN Popular | 3250 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| FVP | 22353 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOTORCRAFT | YB3283 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SKP | SK12883 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| US MOTOR WORKS | 22353 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
6 Radiator Fan Clutch parts are listed for the 2021 Ford E-450, from FOUR SEASONS, HAYDEN, FVP and 3 other brands. FOUR SEASONS 46153 carries the "Popular" badge.
Listed part numbers: FOUR SEASONS 46153, HAYDEN 3250 and FVP 22353, plus the other parts above.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES | 52475 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| MOTORCRAFT | KM6934 | 🇺🇸 US 🇨🇦 CA | Upper | View on Amazon |
| MOTORCRAFT | KM7023 | 🇺🇸 US 🇨🇦 CA | LowerRadiator / Coolant Overflow Container | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
3 Radiator Hose parts for the 2021 Ford E-450 come from 2 brands — MOTORCRAFT and GATES.
Part numbers include GATES 52475, MOTORCRAFT KM6934 and MOTORCRAFT KM7023.
Radiator Mount Bushing
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 927244 | 🇺🇸 US 🇨🇦 CA | Fits Right Lower | View on Amazon |
This table covers the Radiator Mount bushings. Typical signs include a clunk over bumps, or a torn or walked-out bushing you can see. Press the new bushing square. A cocked bushing will tear in a few thousand miles.
This group shows a single part: DORMAN 927244.
Thermostat
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD | MRD109 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | RT1247 | 🇺🇸 US 🇨🇦 CA | 190 Degree Thermostat | View on Amazon |
| MOTORAD | 1121192 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD | 1121160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD | 2080KT | 🇺🇸 US 🇨🇦 CA | Includes Housing and SealKit | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
5 Thermostat parts for the 2021 Ford E-450 come from 2 brands — MOTORAD and MOTORCRAFT. The "Popular" part is MOTORCRAFT RT1247.
The Performance section lists 1 option from MOTORAD — engineered beyond original-equipment specification. MOTORAD MRD109 is listed in this group.
Standard Replacement: 4 parts, from MOTORAD and MOTORCRAFT. A representative part number is MOTORCRAFT RT1247.
This group includes MOTORCRAFT RT1247, MOTORAD MRD109 and MOTORAD 1121192 and the remaining parts above.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular | 33671 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal - 1 63/64" x 2 17/64" x 9/64" (O-Ring) | View on Amazon |
| MOTORCRAFT Popular | RG571 | 🇺🇸 US 🇨🇦 CA | Water Outlet Seal | View on Amazon |
| FEL-PRO | 35489 | 🇺🇸 US 🇨🇦 CA | Outside Diameter: 51.5 mm | View on Amazon |
| MAHLE / CLEVITE | C31302 | 🇺🇸 US 🇨🇦 CA | Engine Coolant Outlet O-RingMolded Rubber | View on Amazon |
| MOTORAD | MG90 | 🇺🇸 US 🇨🇦 CA | Style: O-Ring | View on Amazon |
| MOTORCRAFT | RG654 | 🇺🇸 US 🇨🇦 CA | To Thermostat Housing | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
6 Thermostat / Thermostat Housing / Water Outlet Seal parts are listed for the 2021 Ford E-450, from MOTORCRAFT, GATES, FEL-PRO and 2 other brands. GATES 33671 carries the "Popular" badge.
Part numbers include GATES 33671, MOTORCRAFT RG571 and FEL-PRO 35489, among others listed above.
Thermostat Housing / Water Outlet
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD | CH2080 | 🇺🇸 US 🇨🇦 CA | Fits Thermostat Housingor Water Outlet | View on Amazon |
| MOTORCRAFT | RH286 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
2 Thermostat Housing / Water Outlet parts for the 2021 Ford E-450 come from 2 brands — MOTORAD and MOTORCRAFT.
Listed part numbers: MOTORAD CH2080 and MOTORCRAFT RH286.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE | C33825 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2021 Ford E-450 — MAHLE / CLEVITE C33825.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Popular | SK1254040 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP | US8188 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS | US8188 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORCRAFT Popular | PW629 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP | 1254040 | 🇺🇸 US 🇨🇦 CA | Water Pump Drive Type: Serpentine Belt | View on Amazon |
| GATES | 43187 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB | 1254040 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
7 Water Pump parts for the 2021 Ford E-450 come from 6 brands — FVP, SKP, US MOTOR WORKS and 3 other brands. The "Popular" part is SKP SK1254040.
The Economy section: 3 options from SKP, FVP and US MOTOR WORKS. SKP SK1254040 is listed in this group.
Standard Replacement: 4 parts, from MOTORCRAFT, FVP, GATES and 1 other brand. A representative part number is MOTORCRAFT PW629.
Listed part numbers: SKP SK1254040 and FVP US8188, plus the other parts above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MAHLE / CLEVITE | K33826 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2021 Ford E-450 — MAHLE / CLEVITE K33826.
Buying Cooling System Parts for a 2021 Ford E-450
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Water Pump .
Frequently Asked Questions
How many cooling system parts fit the 2021 Ford E-450?
Our catalog currently lists 58 cooling system parts for the 2021 Ford E-450 across 15 subcategories and 19 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of cooling system problems on a 2021 Ford E-450?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ford E-450 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Ford E-450?
Every part on this page is matched to the 7.3L V8 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Ford E-450
Cooling System Parts for Other Ford E-450 Years
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