The 2021 Ford E-450 has 27 drivetrain parts with verified fitment on this page — 7 part types and 12 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.
On the 2021 Ford E-450, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. Most of the listed parts are Universal Joint (16 parts), Drive Shaft Center Support Bearing (3 parts) and Differential Pinion Seal (2 parts). The other 4 part types cover the remaining 6 parts.
Every part on this page is matched to the 7.3L V8 — the only engine offered in the 2021 Ford E-450.
The most listed brands for 2021 Ford E-450 drivetrain parts are SKF (8 parts), ACDELCO (5 parts) and DORMAN (3 parts), plus 9 more brands. Quality grades include Standard Replacement, Heavy Duty and Economy.
4 parts on this 2021 Ford E-450 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including MOOG 295 (Universal Joint) and SKF UJ232 (Universal Joint). Click any part number to see every vehicle that part fits.
Axle Shaft Flange Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 926880 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the gaskets that seal the Axle Shaft Flange. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2021 Ford E-450 — DORMAN 926880.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SCHAEFFLER | SS2923 | 🇺🇸 US 🇨🇦 CA | Rear Outer3.21" O.D. X 0.5" Width | View on Amazon |
| TIMKEN | 100715V | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
2 Differential Pinion Seal parts for the 2021 Ford E-450 come from 2 brands — SCHAEFFLER and TIMKEN.
Part numbers include SCHAEFFLER SS2923 and TIMKEN 100715V.
Differential Rebuild Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BCA | NBRA332HD | 🇺🇸 US 🇨🇦 CA | Standard Kit | View on Amazon |
| LUK | GDK332HD | 🇺🇸 US 🇨🇦 CA | Standard Kit | View on Amazon |
This table covers kits that group the bearings, races and seals for a differential rebuild.
2 Differential Rebuild Kit parts are listed for the 2021 Ford E-450, from BCA and LUK.
Part numbers include BCA NBRA332HD and LUK GDK332HD.
Drive Shaft Bolt
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 80992 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the Drive Shaft bolts.
This group shows a single part: DORMAN 80992.
Drive Shaft Center Support Bearing
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DEA / MARMON RIDE CONTROL | A60079 | 🇺🇸 US 🇨🇦 CA | MRC Driveline | View on Amazon |
| DORMAN | 934007 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ANCHOR | 6053 | 🇺🇸 US 🇨🇦 CA | Centerwithout Mounting Studs | View on Amazon |
This table covers the Drive Shaft Center Support bearings. Typical signs include a growl that rises with speed, or play in the shaft or hub. Set preload the way the notes specify. A dry or crushed bearing fails quickly.
3 Drive Shaft Center Support Bearing parts are listed for the 2021 Ford E-450, from DEA / MARMON RIDE CONTROL, DORMAN and ANCHOR.
In the Economy grade, DEA / MARMON RIDE CONTROL and DORMAN supply 2 parts: the catalog's value-priced group. A representative part number is DEA / MARMON RIDE CONTROL A60079.
The Standard Replacement section lists 1 option from ANCHOR — built to original-equipment specification. ANCHOR 6053 is listed in this group.
Listed part numbers: DEA / MARMON RIDE CONTROL A60079, DORMAN 934007 and ANCHOR 6053.
Gear Oil
SAE 75W-140
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL | 102490 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-14 0Mobil 1 Synthetic Gear Lubricant LS 75W-14 0 | View on Amazon |
SAE 75W-90
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL | 104361 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-901 Quart | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
2 Gear Oil parts for the 2021 Ford E-450 come from MOBIL.
The SAE 75W-140 section lists 1 option from MOBIL — grouped under the catalog's "SAE 75W-140" designation — the notes column spells out what sets them apart. MOBIL 102490 is listed in this group.
The SAE 75W-90 section lists 1 option from MOBIL — grouped under the catalog's "SAE 75W-90" designation — the notes column spells out what sets them apart. MOBIL 104361 is listed in this group.
This group includes MOBIL 102490 and MOBIL 104361.
Universal Joint
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOOG Popular | 295 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
| SKF Popular | UJ232 | 🇺🇸 US 🇨🇦 CA | Brute Force Greaseable | View on Amazon |
| ACDELCO | 45U0109 | 🇺🇸 US 🇨🇦 CA | Greasable Super Strength | View on Amazon |
| ACDELCO | 45U0123 | 🇺🇸 US 🇨🇦 CA | Non-Greasable Super Strength | View on Amazon |
| ACDELCO | 45U0304 | 🇺🇸 US 🇨🇦 CA | Greasable Super Strength | View on Amazon |
| SKF | UJ231 | 🇺🇸 US 🇨🇦 CA | Brute Force Non Greaseable | View on Amazon |
| SKF | UJ295 | 🇺🇸 US 🇨🇦 CA | Brute Force Greaseable | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOOG Popular | 330 | 🇺🇸 US 🇨🇦 CA | Greasable | View on Amazon |
| SKF Popular | UJ331 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| AAM | 19256728 | 🇺🇸 US 🇨🇦 CA | Rear Shaftwith 1355 U-Joints | View on Amazon |
| ACDELCO | 45U0103 | 🇺🇸 US 🇨🇦 CA | Gold | View on Amazon |
| ACDELCO | 45U0300 | 🇺🇸 US 🇨🇦 CA | Gold | View on Amazon |
| SKF | UJ33010 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ330 | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ331C | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
| SKF | UJ330C | 🇺🇸 US 🇨🇦 CA | Greaseable | View on Amazon |
This table covers the U-joints in the driveshaft.
16 Universal Joint parts for the 2021 Ford E-450 come from 4 brands — SKF, ACDELCO, MOOG and 1 other brand. The "Popular" part is MOOG 295.
In the Heavy Duty grade, SKF, ACDELCO and MOOG supply 7 parts: rated for severe service. A representative part number is MOOG 295.
Standard Replacement: 9 parts, from SKF, ACDELCO, MOOG and 1 other brand. A representative part number is MOOG 330.
Buying Drivetrain Parts for a 2021 Ford E-450
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Universal Joint and Drive Shaft Center Support Bearing .
Frequently Asked Questions
How many drivetrain parts fit the 2021 Ford E-450?
Our catalog currently lists 27 drivetrain parts for the 2021 Ford E-450 across 7 subcategories and 12 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2021 Ford E-450?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Ford E-450 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Ford E-450?
Every part on this page is matched to the 7.3L V8 engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Ford E-450
Drivetrain Parts for Other Ford E-450 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.