The 2021 Freightliner Sprinter 4500 has 24 cooling system parts with verified fitment on this page — 4 part types and 10 brands, covering the 3.0L V6 DIESEL Turbocharged engine. Each part includes a manufacturer part number and application notes.
On the 2021 Freightliner Sprinter 4500, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. Most of the listed parts are Coolant / Antifreeze (13 parts), Water Pump (7 parts) and Coolant Filter (2 parts). The other 1 part type covers the remaining 2 parts.
Every part on this page is matched to the 3.0L V6 DIESEL Turbocharged — the only engine offered in the 2021 Freightliner Sprinter 4500.
The most listed brands for 2021 Freightliner Sprinter 4500 cooling system parts are PRESTONE (5 parts), PEAK (5 parts) and PENTOSIN (3 parts), plus 7 more brands. Quality grades include Standard Replacement, Economy and Premium.
4 parts on this 2021 Freightliner Sprinter 4500 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including PRESTONE AF3100 (Coolant / Antifreeze) and GMB 1204400 (Water Pump). Click any part number to see every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE | AF3055 | 🇺🇸 US | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF3100 | 🇺🇸 US | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| PEAK | BQA1GAL | 🇺🇸 US | Blue Mountain Long LifeAll Vehicle | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PEAK | FXA1GAL | 🇺🇸 US | Final Charge Global1 Gallon | View on Amazon |
| PRESTONE | AFC12100 | 🇺🇸 US | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular | AF2100 | 🇺🇸 US | All Vehicles10yr/300k mi | View on Amazon |
| PEAK | PKP1GAL | 🇺🇸 US | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK | PXA1GAL | 🇺🇸 US | Global Lifetime1 Gallon | View on Amazon |
| PRESTONE | AFMAX | 🇺🇸 US | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PENTOSIN Popular | 8113106 | 🇺🇸 US | Pentofrost E1.5 Liters | View on Amazon |
| PEAK | PEV1GAL | 🇺🇸 US | OET European Extended Life Violet1 Gallon | View on Amazon |
| PENTOSIN | 8114306 | 🇺🇸 US | Pentofrost E1 Gallon | View on Amazon |
| PENTOSIN | 8113206 | 🇺🇸 US | Pentofrost E5 Liters | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
13 Coolant / Antifreeze parts for the 2021 Freightliner Sprinter 4500 come from 3 brands — PRESTONE, PEAK and PENTOSIN. The "Popular" part is PRESTONE AF3100.
In the Compatible With All Colors grade, PRESTONE supplies 1 part: grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. A representative part number is PRESTONE AF3055.
The Economy section lists 2 options from PRESTONE and PEAK — the catalog's value-priced group. PRESTONE AF3100 is listed in this group.
In the Heavy Duty grade, PEAK and PRESTONE supply 2 parts: rated for severe service. A representative part number is PEAK FXA1GAL.
In the Premium grade, PRESTONE and PEAK supply 4 parts: a step above OE specification in materials, tolerances or warranty terms. A representative part number is PRESTONE AF2100.
In the Standard Replacement grade, PENTOSIN and PEAK supply 4 parts: built to original-equipment specification. A representative part number is PENTOSIN 8113106.
Coolant Filter
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FAMOUS BRAND | 89155 | 🇺🇸 US 🇨🇦 CA | CoolantOE Number : A4722030355 | View on Amazon |
| HASTINGS / BALDWIN | P5092 | 🇺🇸 US | View on Amazon |
This table covers the Coolant filters. Typical signs include restricted flow — long cranking, weak airflow, or dirty fluid after a short interval. Seat the new filter so it cannot bypass, and use the grade the notes call for.
2 Coolant Filter parts for the 2021 Freightliner Sprinter 4500 come from 2 brands — FAMOUS BRAND and HASTINGS / BALDWIN.
Part numbers include FAMOUS BRAND 89155 and HASTINGS / BALDWIN P5092.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN | CHR0713 | 🇺🇸 US | Upper | View on Amazon |
| REIN | CHR0664 | 🇺🇸 US | Lowerwithout Roof AC | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
REIN supplies both parts for the 2021 Freightliner Sprinter 4500.
Listed part numbers: REIN CHR0713 and REIN CHR0664.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| REIN | WPA0531 | 🇺🇸 US | Auxiliary | View on Amazon |
| SKP | SK1473080 | 🇺🇸 US | without Mounting Bracket | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GMB Popular | 1204400 | 🇺🇸 US | View on Amazon | |
| DAYCO | DP354 | 🇺🇸 US | Serpentine Belt Driven | View on Amazon |
| FVP | 1204400 | 🇺🇸 US | View on Amazon | |
| FVP | 1473080 | 🇺🇸 US | without Mounting BracketAuxiliary | View on Amazon |
| GMB | 1472410 | 🇺🇸 US | Mounting Hardware Included: No | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
7 Water Pump parts are listed for the 2021 Freightliner Sprinter 4500, from GMB, FVP, REIN and 2 other brands. GMB 1204400 carries the "Popular" badge.
Economy: 2 parts, from REIN and SKP. A representative part number is REIN WPA0531.
The Standard Replacement section: 5 options from GMB, FVP and DAYCO. GMB 1204400 is listed in this group.
This group includes GMB 1204400, REIN WPA0531 and SKP SK1473080 and the remaining parts above.
Buying Cooling System Parts for a 2021 Freightliner Sprinter 4500
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Confirm you have the 3.0L V6 DIESEL Turbocharged engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Coolant / Antifreeze and Water Pump .
Frequently Asked Questions
How many cooling system parts fit the 2021 Freightliner Sprinter 4500?
Our catalog currently lists 24 cooling system parts for the 2021 Freightliner Sprinter 4500 across 4 subcategories and 10 brands, covering the 3.0L V6 DIESEL Turbocharged engine. Each part is matched to the engine(s) it fits.
What are the signs of cooling system problems on a 2021 Freightliner Sprinter 4500?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Freightliner Sprinter 4500 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2021 Freightliner Sprinter 4500?
Every part on this page is matched to the 3.0L V6 DIESEL Turbocharged engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2021 Freightliner Sprinter 4500
Cooling System Parts for Other Freightliner Sprinter 4500 Years
Switch vehicle or jump to a subcategory
Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.