The 2006 Isuzu Ascender has 214 cooling system parts with verified fitment on this page — 25 part types and 46 brands, covering both the 4.2L L6 and the 5.3L V8. Each part includes a manufacturer part number and application notes.
On the 2006 Isuzu Ascender, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. 74 parts of the 214 listed are Thermostat (27 parts), Temperature Sender / Sensor (24 parts) and Water Pump (23 parts). The other 22 part types cover the remaining 140 parts.
The 2006 Isuzu Ascender was sold with both the 4.2L L6 and the 5.3L V8. 48 parts fit every engine; the other 166 are engine-specific. Each part shows which engine(s) it fits.
46 brands supply cooling system parts for the 2006 Isuzu Ascender, led by GM GENUINE (20 parts), MOTORAD (19 parts) and GATES (14 parts), plus 43 more brands. Quality grades include Standard Replacement, Economy and Premium.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2006 Isuzu Ascender. 41 parts have it, including FVP MV5050GAL (Coolant / Antifreeze) and CSF 3108 (Radiator). Each part number opens a page with every vehicle that part fits.
Coolant / Antifreeze
Compatible With All Colors
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2006 Ascender engines | AF3055 | 🇺🇸 US 🇨🇦 CA | Prime YellowAll Vehicles | View on Amazon |
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FVP Popular Fits: all 2006 Ascender engines | MV5050GAL | 🇺🇸 US 🇨🇦 CA | Extended LifeAll Makes / All Models | View on Amazon |
| PEAK Fits: all 2006 Ascender engines | BQA1GAL | 🇺🇸 US 🇨🇦 CA | Blue Mountain Long LifeAll Vehicle | View on Amazon |
| PRESTONE Fits: all 2006 Ascender engines | AF3100 | 🇺🇸 US 🇨🇦 CA | Prime Yellow - All VehiclesExtended Life | View on Amazon |
| VALVOLINE Fits: all 2006 Ascender engines | 719009 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle Yellow1 Gallon | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Fits: all 2006 Ascender engines | AFC12100 | 🇺🇸 US 🇨🇦 CA | Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PRESTONE Popular Fits: all 2006 Ascender engines | AF2100 | 🇺🇸 US 🇨🇦 CA | All Vehicles10yr/300k mi | View on Amazon |
| PEAK Fits: all 2006 Ascender engines | PKP1GAL | 🇺🇸 US 🇨🇦 CA | All Vehicles Antifreeze1 Gallon | View on Amazon |
| PEAK Fits: all 2006 Ascender engines | PXA1GAL | 🇺🇸 US 🇨🇦 CA | 1 GallonGlobal Lifetime | View on Amazon |
| PRESTONE Fits: all 2006 Ascender engines | AF6610 | 🇺🇸 US 🇨🇦 CA | MAX Asian Green1 Gallon | View on Amazon |
| PRESTONE Fits: all 2006 Ascender engines | AFMAX | 🇺🇸 US 🇨🇦 CA | Max Universal1 Gallon | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: all 2006 Ascender engines | 105027 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended LifeDexcool (with DE-Ionized Water) (with Bitterant) 1 Gallon | View on Amazon |
| VALVOLINE Popular Fits: all 2006 Ascender engines | ZXEL1 | 🇺🇸 US 🇨🇦 CA | Dex-Cool Orange1 Gallon | View on Amazon |
| FVP Fits: all 2006 Ascender engines | DEX5050GAL | 🇺🇸 US 🇨🇦 CA | Extended Life Blend1 Gallon | View on Amazon |
| PEAK Fits: all 2006 Ascender engines | PDC1GAL | 🇺🇸 US 🇨🇦 CA | GM DEX-Cool1 Gallon | View on Amazon |
| PRESTONE Fits: all 2006 Ascender engines | AF3400 | 🇺🇸 US 🇨🇦 CA | Prime OrangeOrange Compatible | View on Amazon |
| PRESTONE Fits: all 2006 Ascender engines | AF850 | 🇺🇸 US 🇨🇦 CA | DEX-Cool Extended Life1 Gallon | View on Amazon |
| VALVOLINE Fits: all 2006 Ascender engines | 675130 | 🇺🇸 US 🇨🇦 CA | Asian Vehicle Red1 Gallon | View on Amazon |
This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.
18 Coolant / Antifreeze parts are listed for the 2006 Isuzu Ascender, from PRESTONE, PEAK, VALVOLINE and 2 other brands. FVP MV5050GAL carries the "Popular" badge. All of them fit every engine offered in the 2006 Ascender.
The Compatible With All Colors section lists 1 option from PRESTONE — grouped under the catalog's "Compatible With All Colors" designation — the notes column spells out what sets them apart. PRESTONE AF3055 is listed in this group.
In the Economy grade, FVP, PEAK, PRESTONE and 1 other brand supply 4 parts: the catalog's value-priced group. A representative part number is FVP MV5050GAL.
The Heavy Duty section lists 1 option from PRESTONE — rated for severe service. PRESTONE AFC12100 is listed in this group.
The Premium section lists 5 options from PRESTONE and PEAK — a step above OE specification in materials, tolerances or warranty terms. PRESTONE AF2100 is listed in this group.
The Standard Replacement section lists 7 options from VALVOLINE, PRESTONE, ACDELCO and 2 other brands — built to original-equipment specification. ACDELCO 105027 is listed in this group.
Coolant Air Bleed Hose / Pipe
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 5.3L V8 | 626591 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 5.3L V8 | 12600254 | 🇺🇸 US 🇨🇦 CA | End 1 Inside Diameter (In): 0.22 In | View on Amazon |
| GM GENUINE Fits: 5.3L V8 | 12694768 | 🇺🇸 US 🇨🇦 CA | Breather Pipe | View on Amazon |
This table covers the Coolant Air Bleed Hose pipes.
3 Coolant Air Bleed Hose / Pipe parts are listed for the 2006 Isuzu Ascender, from GM GENUINE and DORMAN.
Listed part numbers: DORMAN 626591, GM GENUINE 12600254 and GM GENUINE 12694768.
Coolant Air Bleeder
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 5.3L V8 | 12602048 | 🇺🇸 US 🇨🇦 CA | Aluminum51mm | View on Amazon |
This table covers the bleeders used to purge air from the coolant circuit.
This group shows a single part: GM GENUINE 12602048.
Coolant Hose / Pipe Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ELRING Fits: all 2006 Ascender engines | 868630 | 🇺🇸 US 🇨🇦 CA | COOLANT PIPE | View on Amazon |
| FEL-PRO Fits: 4.2L L6 | 36017 | 🇺🇸 US 🇨🇦 CA | COOLANT PIPE | View on Amazon |
This table covers the seals at the Coolant Hose / Pipe. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
2 Coolant Hose / Pipe Seal parts for the 2006 Isuzu Ascender come from 2 brands — ELRING and FEL-PRO. 1 part fits every engine; the other 1 is engine-specific.
Part numbers include ELRING 868630 and FEL-PRO 36017.
Coolant Reservoir
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2006 Ascender engines | 603126 | 🇺🇸 US 🇨🇦 CA | Low Fluid Sensor Not Included | View on Amazon |
| GM GENUINE Fits: 4.2L L6 | 89022552 | 🇺🇸 US 🇨🇦 CA | Tank Kit Only | View on Amazon |
| GPD Fits: all 2006 Ascender engines | 2411029 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the overflow / expansion tanks that hold extra coolant.
3 Coolant Reservoir parts for the 2006 Isuzu Ascender come from 3 brands — DORMAN, GM GENUINE and GPD. 2 parts fit every engine; the other 1 is engine-specific.
Part numbers include DORMAN 603126, GM GENUINE 89022552 and GPD 2411029.
Coolant Reservoir Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2006 Ascender engines | RC122 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| MOTORAD Fits: all 2006 Ascender engines | T46 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
2 Coolant Reservoir Cap parts for the 2006 Isuzu Ascender come from 2 brands — GM GENUINE and MOTORAD. Every part fits both the 4.2L L6 and the 5.3L V8.
Part numbers include GM GENUINE RC122 and MOTORAD T46.
Coolant Water Crossover Mounting Set
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Fits: 5.3L V8 | ES73027 | 🇺🇸 US 🇨🇦 CA | Coolant bleed pipe seals | View on Amazon |
| MAHLE / CLEVITE Fits: 5.3L V8 | GS33845 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| VICTOR REINZ Fits: 5.3L V8 | 181002301 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Coolant Water Crossover Mounting sets.
3 Coolant Water Crossover Mounting Set parts are listed for the 2006 Isuzu Ascender, from FEL-PRO, MAHLE / CLEVITE and VICTOR REINZ.
Listed part numbers: FEL-PRO ES73027, MAHLE / CLEVITE GS33845 and VICTOR REINZ 181002301.
Cooling Fan Control Module
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| US MOTOR WORKS Fits: all 2006 Ascender engines | 16749 | 🇺🇸 US 🇨🇦 CA | Econo Control | View on Amazon |
| US MOTOR WORKS Fits: 4.2L L6 | 16779 | 🇺🇸 US 🇨🇦 CA | Better Control | View on Amazon |
| US MOTOR WORKS Fits: all 2006 Ascender engines | 16795 | 🇺🇸 US 🇨🇦 CA | Best Control | View on Amazon |
| US MOTOR WORKS Fits: 5.3L V8 | 16789 | 🇺🇸 US 🇨🇦 CA | Better Control | View on Amazon |
This table covers the Cooling Fan control modules.
4 Cooling Fan Control Module parts for the 2006 Isuzu Ascender come from US MOTOR WORKS. 2 parts fit every engine; the other 2 are engine-specific.
This group includes US MOTOR WORKS 16749, US MOTOR WORKS 16779 and US MOTOR WORKS 16795 and the remaining parts above.
Cooling System Tester Adapter
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Fits: all 2006 Ascender engines | 31431 | 🇺🇸 US 🇨🇦 CA | Cooling System Pressure | View on Amazon |
| GATES Fits: all 2006 Ascender engines | 31391 | 🇺🇸 US 🇨🇦 CA | Cooling System PressureRadiator Cap | View on Amazon |
| MOTORAD Fits: all 2006 Ascender engines | 3128 | 🇺🇸 US 🇨🇦 CA | StandardRadiator Cap Adapter | View on Amazon |
| MOTORAD Fits: all 2006 Ascender engines | 3127 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
This table covers the adapters used to pressure-test this cooling system.
4 Cooling System Tester Adapter parts are listed for the 2006 Isuzu Ascender, from GATES and MOTORAD. All of them fit every engine offered in the 2006 Ascender.
This group includes GATES 31431, GATES 31391 and MOTORAD 3128 and the remaining parts above.
Hose Clamp
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 5.3L V8 | 11570393 | 🇺🇸 US 🇨🇦 CA | LowerRadiator Hose | View on Amazon |
This table covers the Hose clamps.
One part is listed for the 2006 Isuzu Ascender — GM GENUINE 11570393.
Radiator
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GPD Fits: 4.2L L6 | 2458C | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GPD Fits: 5.3L V8 | 2563C | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| OSC Fits: 4.2L L6 | 2458E | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| CSF Popular Fits: all 2006 Ascender engines | 3108 | 🇺🇸 US 🇨🇦 CA | 1 RowPlastic Tank / Aluminum Core | View on Amazon |
| CSF Popular Fits: 4.2L L6 | 3107 | 🇺🇸 US 🇨🇦 CA | 1 RowPlastic Tank / Aluminum Core | View on Amazon |
| KOYORAD Popular Fits: 4.2L L6 | A2458 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| KOYORAD Popular Fits: 5.3L V8 | A2563 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| AGILITY Fits: 4.2L L6 | 8012458 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| AGILITY Fits: 5.3L V8 | 8012563 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 4.2L L6 | RAD2458 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 5.3L V8 | RAD2563 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Fits: 4.2L L6 | 21505 | 🇺🇸 US 🇨🇦 CA | Drain Cock Not IncludedCore Size 27 IN X 18 1/8 IN X 7/8 IN | View on Amazon |
| OSC Fits: 4.2L L6 | 2458 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| OSC Fits: 5.3L V8 | 2563 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SPECTRA PREMIUM Fits: 4.2L L6 | CU2458 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SPECTRA PREMIUM Fits: 5.3L V8 | CU2563 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UAC Fits: 4.2L L6 | RA2458C | 🇺🇸 US 🇨🇦 CA | Downflow | View on Amazon |
| UAC Fits: 5.3L V8 | RA2563C | 🇺🇸 US 🇨🇦 CA | Downflow | View on Amazon |
This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.
18 Radiator parts are listed for the 2006 Isuzu Ascender, from OSC, GPD, CSF and 6 other brands. CSF 3108 carries the "Popular" badge. 1 part fits every engine; the other 17 are engine-specific.
Economy: 3 parts, from GPD and OSC. A representative part number is GPD 2458C.
The Standard Replacement section: 15 options from CSF, KOYORAD, AGILITY and 5 other brands. CSF 3108 is listed in this group.
Radiator Cap
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Fits: all 2006 Ascender engines | RC85 | 🇺🇸 US 🇨🇦 CA | GM Original Equipment | View on Amazon |
| GATES Fits: all 2006 Ascender engines | 31532 | 🇺🇸 US 🇨🇦 CA | OE Type | View on Amazon |
This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.
2 Radiator Cap parts are listed for the 2006 Isuzu Ascender, from ACDELCO and GATES. All of them fit every engine offered in the 2006 Ascender.
Part numbers include ACDELCO RC85 and GATES 31532.
Radiator Fan Blade
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: all 2006 Ascender engines | 1580696 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.
This group shows a single part: GM GENUINE 1580696.
Radiator Fan Clutch
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| BECK/ARNLEY Popular Fits: all 2006 Ascender engines | 1300229 | 🇺🇸 US 🇨🇦 CA | Thermal | View on Amazon |
| HAYDEN Popular Fits: all 2006 Ascender engines | 3200 | 🇺🇸 US 🇨🇦 CA | Severe Duty Electronic | View on Amazon |
| ULTRA-POWER Popular Fits: all 2006 Ascender engines | 622001 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| DORMAN Fits: all 2006 Ascender engines | 622001 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FOUR SEASONS Fits: all 2006 Ascender engines | 46024 | 🇺🇸 US 🇨🇦 CA | Severe Duty Electronic | View on Amazon |
| FVP Fits: all 2006 Ascender engines | 22310 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| FVP Fits: all 2006 Ascender engines | 9302030 | 🇺🇸 US 🇨🇦 CA | Severe DutyElectronic | View on Amazon |
| GM GENUINE Fits: all 2006 Ascender engines | 1540133 | 🇺🇸 US 🇨🇦 CA | Includes Sensor | View on Amazon |
| GMB Fits: all 2006 Ascender engines | 9302030 | 🇺🇸 US 🇨🇦 CA | Severe DutyElectronic | View on Amazon |
| GPD Fits: all 2006 Ascender engines | 2911336 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
| MAHLE / CLEVITE Fits: all 2006 Ascender engines | CFC83000S | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS Fits: all 2006 Ascender engines | 22310 | 🇺🇸 US 🇨🇦 CA | Electronic | View on Amazon |
This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.
12 Radiator Fan Clutch parts are listed for the 2006 Isuzu Ascender, from FVP, BECK/ARNLEY, HAYDEN and 8 other brands. BECK/ARNLEY 1300229 carries the "Popular" badge. All of them fit every engine offered in the 2006 Ascender.
Radiator Fan Shroud
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VARIOUS MFR Fits: 4.2L L6 | GM3110151 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the shrouds that duct air through the fan and radiator.
One part is listed for the 2006 Isuzu Ascender — VARIOUS MFR GM3110151.
Radiator Hose
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 4.2L L6 | 20382S | 🇺🇸 US 🇨🇦 CA | Professional / GoldMolded | View on Amazon |
| ACDELCO Popular Fits: 5.3L V8 | 24488L | 🇺🇸 US 🇨🇦 CA | Professional / GoldMolded | View on Amazon |
| DAYCO Popular Fits: 5.3L V8 | 72271 | 🇺🇸 US 🇨🇦 CA | Curved | View on Amazon |
| GATES Popular Fits: 4.2L L6 | 22652 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| ACDELCO Fits: 4.2L L6 | 26398X | 🇺🇸 US 🇨🇦 CA | Professional / GoldMolded | View on Amazon |
| ACDELCO Fits: 5.3L V8 | 22464M | 🇺🇸 US 🇨🇦 CA | Professional / GoldMolded | View on Amazon |
| CONTINENTAL Fits: 4.2L L6 | 62422 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| CONTINENTAL Fits: 4.2L L6 | 62423 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| CONTINENTAL Fits: 5.3L V8 | 62424 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| CONTINENTAL Fits: 5.3L V8 | 62425 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| DAYCO Fits: 4.2L L6 | 71078 | 🇺🇸 US 🇨🇦 CA | Curved | View on Amazon |
| DAYCO Fits: 4.2L L6 | 72193 | 🇺🇸 US 🇨🇦 CA | Curved | View on Amazon |
| DAYCO Fits: 5.3L V8 | 72272 | 🇺🇸 US 🇨🇦 CA | Curved | View on Amazon |
| GATES Fits: 4.2L L6 | 22651 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GATES Fits: 5.3L V8 | 22753 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
| GATES Fits: 5.3L V8 | 22754 | 🇺🇸 US 🇨🇦 CA | Molded | View on Amazon |
This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.
16 Radiator Hose parts for the 2006 Isuzu Ascender come from 4 brands — ACDELCO, DAYCO, GATES and 1 other brand. The "Popular" part is ACDELCO 20382S.
Temperature Sender / Sensor
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Popular Fits: 5.3L V8 | SKTX89 | 🇺🇸 US 🇨🇦 CA | Fine thread | View on Amazon |
| GPD Fits: 4.2L L6 | 1712673 | 🇺🇸 US 🇨🇦 CA | with 2 Terminal(s)with M10 x 1.5 Thread | View on Amazon |
| GPD Fits: 5.3L V8 | 1712489 | 🇺🇸 US 🇨🇦 CA | with 2 Terminal(s)with M12 x 1.5 Thread | View on Amazon |
| HOLSTEIN Fits: 4.2L L6 | 2CTS0045 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HOLSTEIN Fits: 5.3L V8 | 2CTS0318 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS Fits: 4.2L L6 | TX136T | 🇺🇸 US 🇨🇦 CA | T-Series | View on Amazon |
| STANDARD MOTOR PRODUCTS Fits: 5.3L V8 | TX89T | 🇺🇸 US 🇨🇦 CA | T-Series | View on Amazon |
| UNITED MOTOR PRODUCTS Fits: 4.2L L6 | CTS141 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| UNITED MOTOR PRODUCTS Fits: 5.3L V8 | CTS73 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Full Service Kit
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| WALKER PRODUCTS Fits: 5.3L V8 | 21191118 | 🇺🇸 US 🇨🇦 CA | Full Service Kit | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular Fits: 5.3L V8 | 2134514 | 🇺🇸 US 🇨🇦 CA | Gold | View on Amazon |
| GM GENUINE Popular Fits: 4.2L L6 | 2134233 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Popular Fits: 5.3L V8 | 2134333 | 🇺🇸 US 🇨🇦 CA | White or BlackUse with Mating Connector PT1798 | View on Amazon |
| WELLS Popular Fits: 4.2L L6 | 5S8203 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| DELPHI Fits: 5.3L V8 | TS10076 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FOUR SEASONS Fits: 5.3L V8 | 36419 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| HELLA Fits: 5.3L V8 | 009107271 | 🇺🇸 US 🇨🇦 CA | 2-Pin ConnectorBolted | View on Amazon |
| NTK Fits: 4.2L L6 | EF0174 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| NTK Fits: 5.3L V8 | EF0075 | 🇺🇸 US 🇨🇦 CA | Connector Shape: Oblong | View on Amazon |
| STANDARD MOTOR PRODUCTS Fits: 4.2L L6 | TX136 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| STANDARD MOTOR PRODUCTS Fits: 5.3L V8 | TX89 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| WALKER PRODUCTS Fits: 4.2L L6 | 2111069 | 🇺🇸 US 🇨🇦 CA | Sensor Only | View on Amazon |
| WALKER PRODUCTS Fits: 5.3L V8 | 2111118 | 🇺🇸 US 🇨🇦 CA | Sensor Only | View on Amazon |
| WELLS Fits: 5.3L V8 | 5S1475 | 🇺🇸 US 🇨🇦 CA | Terminal Quantity: 2Terminal Type: Blade | View on Amazon |
This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.
24 Temperature Sender / Sensor parts are listed for the 2006 Isuzu Ascender, from STANDARD MOTOR PRODUCTS, WALKER PRODUCTS, GPD and 10 other brands. SKP SKTX89 carries the "Popular" badge.
Economy: 9 parts, from GPD, HOLSTEIN, STANDARD MOTOR PRODUCTS and 2 other brands. A representative part number is SKP SKTX89.
In the Full Service Kit grade, WALKER PRODUCTS supplies 1 part: grouped under the catalog's "Full Service Kit" designation — the notes column spells out what sets them apart. A representative part number is WALKER PRODUCTS 21191118.
The Standard Replacement section: 14 options from GM GENUINE, WELLS, NTK and 6 other brands. ACDELCO 2134514 is listed in this group.
Thermostat
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: 5.3L V8 | 9022836 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| SKP Fits: 4.2L L6 | SK9022131 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
| SKP Fits: 5.3L V8 | SK9022836 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 5.3L V8 | 5456187 | 🇺🇸 US 🇨🇦 CA | Ultra StatIncludes seal | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 524KTUS | 🇺🇸 US 🇨🇦 CA | Includes Inlet, Ultra Stat thermostat and sealKit | View on Amazon |
Performance
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 5.3L V8 | MRD104 | 🇺🇸 US 🇨🇦 CA | RacingIncludes Thermostat and Seal | View on Amazon |
Premium
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOTORAD Fits: 5.3L V8 | 7456187 | 🇺🇸 US 🇨🇦 CA | Fail-SafeIncludes seal | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 524KTFS | 🇺🇸 US 🇨🇦 CA | Fail-SafeIncludes Inlet, and Seal | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular Fits: 4.2L L6 | 33939 | 🇺🇸 US 🇨🇦 CA | Integrated Housing Thermostat | View on Amazon |
| GM GENUINE Popular Fits: 4.2L L6 | 1511006 | 🇺🇸 US 🇨🇦 CA | Includes Housing, Seals, Valve,Retainer and Pipes | View on Amazon |
| GM GENUINE Popular Fits: 5.3L V8 | 131156 | 🇺🇸 US 🇨🇦 CA | OE Temperature | View on Amazon |
| GM GENUINE Popular Fits: 5.3L V8 | 1511057 | 🇺🇸 US 🇨🇦 CA | Includes Inlet, Seal, Thermostat | View on Amazon |
| MOTORAD Popular Fits: 5.3L V8 | 456160 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Popular Fits: 5.3L V8 | 456180 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| BECK/ARNLEY Fits: 5.3L V8 | 1430842 | 🇺🇸 US 🇨🇦 CA | Includes Gasket/Seal | View on Amazon |
| CALORSTAT Fits: all 2006 Ascender engines | TH210571J | 🇺🇸 US 🇨🇦 CA | PerformanceIncludes 1 Rubber Gasket | View on Amazon |
| CALORSTAT Fits: all 2006 Ascender engines | TH210582J | 🇺🇸 US 🇨🇦 CA | PerformanceIncludes 1 Rubber Gasket | View on Amazon |
| CALORSTAT Fits: 5.3L V8 | TH210586J | 🇺🇸 US 🇨🇦 CA | Includes 1 Rubber Gasket | View on Amazon |
| GATES Fits: 5.3L V8 | 34702 | 🇺🇸 US 🇨🇦 CA | Integrated Housing Thermostat | View on Amazon |
| MOTORAD Fits: 4.2L L6 | 413192 | 🇺🇸 US 🇨🇦 CA | Includes Housing, Seal | View on Amazon |
| MOTORAD Fits: 4.2L L6 | 413180 | 🇺🇸 US 🇨🇦 CA | Includes Housing, Thermostat, Seal | View on Amazon |
| MOTORAD Fits: 4.2L L6 | 413160 | 🇺🇸 US 🇨🇦 CA | Includes Housing, Thermostat, Seal | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 456187 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 524160 | 🇺🇸 US 🇨🇦 CA | StandardGasket Or Seal Material: Rubber | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 524190 | 🇺🇸 US 🇨🇦 CA | Standard | View on Amazon |
| MOTORAD Fits: 5.3L V8 | 524KT | 🇺🇸 US 🇨🇦 CA | Includes Inlet, Thermostat and SealKit | View on Amazon |
| STANT Fits: 4.2L L6 | 14659 | 🇺🇸 US 🇨🇦 CA | Integrated Thermostat Housing | View on Amazon |
This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.
27 Thermostat parts for the 2006 Isuzu Ascender come from 8 brands — MOTORAD, GM GENUINE, CALORSTAT and 5 other brands. The "Popular" part is GATES 33939. Economy, Heavy Duty, Performance, Premium and Standard Replacement are all represented, and Standard Replacement alone accounts for 19 parts.
Thermostat / Thermostat Housing / Water Outlet Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Popular Fits: 4.2L L6 | 35632 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| MAHLE / CLEVITE Popular Fits: 4.2L L6 | 72141 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| AJUSA Fits: 5.3L V8 | 01670500 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| APEX Fits: 4.2L L6 | AWO2088 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| APEX Fits: 5.3L V8 | AWO2229 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| FEL-PRO Fits: 5.3L V8 | 35720 | 🇺🇸 US 🇨🇦 CA | Thermostat Housing Seal | View on Amazon |
| GM GENUINE Fits: 4.2L L6 | 1533215 | 🇺🇸 US 🇨🇦 CA | Water Outlet Seal | View on Amazon |
| MAHLE / CLEVITE Fits: 4.2L L6 | C31883 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| MAHLE / CLEVITE Fits: 5.3L V8 | C31823 | 🇺🇸 US 🇨🇦 CA | Molded Rubber | View on Amazon |
| VICTOR REINZ Fits: 4.2L L6 | 711347200 | 🇺🇸 US 🇨🇦 CA | Thermostat Seal | View on Amazon |
| VICTOR REINZ Fits: 4.2L L6 | 711424000 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
11 Thermostat / Thermostat Housing / Water Outlet Seal parts are listed for the 2006 Isuzu Ascender, from MAHLE / CLEVITE, FEL-PRO, APEX and 3 other brands. FEL-PRO 35632 carries the "Popular" badge.
Thermostat Housing / Water Outlet
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Popular Fits: 4.2L L6 | 902116 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| AUTOTECNICA Fits: 5.3L V8 | GM0718508 | 🇺🇸 US 🇨🇦 CA | UpperHousing Only | View on Amazon |
| DORMAN Fits: 5.3L V8 | 902836 | 🇺🇸 US 🇨🇦 CA | Does Not Include Thermostat | View on Amazon |
| FAMOUS BRAND Fits: 4.2L L6 | 85096 | 🇺🇸 US 🇨🇦 CA | Water Outlet HousingOutlet | View on Amazon |
| GPD Fits: 4.2L L6 | 8241559 | 🇺🇸 US 🇨🇦 CA | Includes Housing | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Popular Fits: 4.2L L6 | 1510715 | 🇺🇸 US 🇨🇦 CA | Includes Outlet, Connector, Seal | View on Amazon |
| MOTORAD Popular Fits: 5.3L V8 | CH2836 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| FOUR SEASONS Fits: 4.2L L6 | 85096 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| FOUR SEASONS Fits: 5.3L V8 | 85083 | 🇺🇸 US 🇨🇦 CA | Water Outlet | View on Amazon |
| GATES Fits: 4.2L L6 | CO34967 | 🇺🇸 US 🇨🇦 CA | Seal IncludedWater Outlet | View on Amazon |
| GATES Fits: 5.3L V8 | CO34923 | 🇺🇸 US 🇨🇦 CA | Thermostat CoverWater Outlet | View on Amazon |
| MOTORAD Fits: 4.2L L6 | CH5096 | 🇺🇸 US 🇨🇦 CA | Includes Seal | View on Amazon |
This table covers the housings and outlets the thermostat sits in.
12 Thermostat Housing / Water Outlet parts for the 2006 Isuzu Ascender come from 8 brands — DORMAN, MOTORAD, FOUR SEASONS and 5 other brands. The "Popular" part is DORMAN 902116.
The Economy section: 5 options from DORMAN, AUTOTECNICA, FAMOUS BRAND and 1 other brand. DORMAN 902116 is listed in this group.
Standard Replacement: 7 parts, from MOTORAD, FOUR SEASONS, GATES and 1 other brand. A representative part number is GM GENUINE 1510715.
Water Inlet Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GM GENUINE Fits: 5.3L V8 | 131169 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2006 Isuzu Ascender — GM GENUINE 131169.
Water Pump
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| SKP Popular Fits: 5.3L V8 | SK1307340 | 🇺🇸 US 🇨🇦 CA | New Thermostat May Be Requiredwithout Thermostat | View on Amazon |
| US MOTOR WORKS Popular Fits: 4.2L L6 | US5097 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS Popular Fits: 5.3L V8 | US64 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| BECK/ARNLEY Fits: 4.2L L6 | 1312396 | 🇺🇸 US 🇨🇦 CA | Metal Impeller | View on Amazon |
| FVP Fits: 4.2L L6 | US5097 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 5.3L V8 | US64 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FVP Fits: 5.3L V8 | US64T | 🇺🇸 US 🇨🇦 CA | Includes thermostat and thermostat housing | View on Amazon |
| SKP Fits: 4.2L L6 | SK1307700 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| SKP Fits: 5.3L V8 | SK1307340AT | 🇺🇸 US 🇨🇦 CA | Includes Thermostat & Flange | View on Amazon |
| US MOTOR WORKS Fits: 5.3L V8 | US64T | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and Housing | View on Amazon |
| WJB / INMOTION PARTS Fits: 4.2L L6 | WU5097 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GATES Popular Fits: 4.2L L6 | 41122 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GM GENUINE Popular Fits: 5.3L V8 | 12703898 | 🇺🇸 US 🇨🇦 CA | May Require Purchase of Replacement Thermostat | View on Amazon |
| ACDELCO Fits: all 2006 Ascender engines | 252822 | 🇺🇸 US 🇨🇦 CA | GoldDoes Not Include Mount Bolts | View on Amazon |
| DAYCO Fits: 4.2L L6 | DP965 | 🇺🇸 US 🇨🇦 CA | Serpentine Belt Driven | View on Amazon |
| DAYCO Fits: 5.3L V8 | DP998 | 🇺🇸 US 🇨🇦 CA | 47mm Thermostat DiameterSerpentine Belt Driven | View on Amazon |
| GATES Fits: 5.3L V8 | 45005 | 🇺🇸 US 🇨🇦 CA | without Thermostat And Housing | View on Amazon |
| GATES Fits: 5.3L V8 | 45006 | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and Housing | View on Amazon |
| GMB Fits: 4.2L L6 | 1307700 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| GMB Fits: 5.3L V8 | 1307340 | 🇺🇸 US 🇨🇦 CA | 2.05" Diameter Thermostat Opening | View on Amazon |
| GMB Fits: 5.3L V8 | 1307340AT | 🇺🇸 US 🇨🇦 CA | Includes Thermostat | View on Amazon |
| MELLING Fits: 5.3L V8 | MWP502 | 🇺🇸 US 🇨🇦 CA | Includes Mounting GasketsDoes Not Include Thermostat | View on Amazon |
| MELLING Fits: 5.3L V8 | MWP500 | 🇺🇸 US 🇨🇦 CA | Includes Mounting GasketsDoes Not Include Thermostat | View on Amazon |
This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.
23 Water Pump parts for the 2006 Isuzu Ascender come from 11 brands — SKP, US MOTOR WORKS, FVP and 8 other brands. The "Popular" part is SKP SK1307340. 1 part fits every engine; the other 22 are engine-specific.
The Economy section: 11 options from SKP, US MOTOR WORKS, FVP and 2 other brands. SKP SK1307340 is listed in this group.
Standard Replacement: 12 parts, from GATES, GMB, DAYCO and 3 other brands. A representative part number is GATES 41122.
Water Pump & Fan Clutch Assembly
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| US MOTOR WORKS Popular Fits: 5.3L V8 | MCK2001 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| US MOTOR WORKS Popular Fits: 5.3L V8 | MCK2001T | 🇺🇸 US 🇨🇦 CA | Includes Thermostat and Housing | View on Amazon |
| FVP Fits: 5.3L V8 | 1300024 | 🇺🇸 US 🇨🇦 CA | Counter Clockwise (Reverse) RotationSevere Duty | View on Amazon |
| FVP Fits: 5.3L V8 | 1300028 | 🇺🇸 US 🇨🇦 CA | Counter Clockwise (Reverse) RotationSevere Duty | View on Amazon |
| GMB Fits: 5.3L V8 | 1300028 | 🇺🇸 US 🇨🇦 CA | KitSevere Duty | View on Amazon |
| GMB Fits: 5.3L V8 | 1300024 | 🇺🇸 US 🇨🇦 CA | KitSevere Duty | View on Amazon |
| US MOTOR WORKS Fits: 4.2L L6 | MCK1008 | 🇺🇸 US 🇨🇦 CA | Electronic Fan Clutch | View on Amazon |
This table covers the Water Pump & Fan Clutch assemblies.
7 Water Pump & Fan Clutch Assembly parts for the 2006 Isuzu Ascender come from 3 brands — US MOTOR WORKS, FVP and GMB. The "Popular" part is US MOTOR WORKS MCK2001.
Part numbers include US MOTOR WORKS MCK2001, US MOTOR WORKS MCK2001T and FVP 1300024, among others listed above.
Water Pump Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| FEL-PRO Popular Fits: 5.3L V8 | ES73010 | 🇺🇸 US 🇨🇦 CA | Gasket Kit | View on Amazon |
| GM GENUINE Popular Fits: 4.2L L6 | 2512029 | 🇺🇸 US 🇨🇦 CA | (OEM Design) | View on Amazon |
| GM GENUINE Popular Fits: 5.3L V8 | 251663 | 🇺🇸 US 🇨🇦 CA | 2 Oblong and 1 Round Mounting Holes, At Pump Manifold | View on Amazon |
| APEX Fits: 4.2L L6 | AWP3180 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| APEX Fits: 5.3L V8 | AWP3016 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FEL-PRO Fits: 4.2L L6 | 35704 | 🇺🇸 US 🇨🇦 CA | To Block | View on Amazon |
| FEL-PRO Fits: 5.3L V8 | 35635 | 🇺🇸 US 🇨🇦 CA | To Block | View on Amazon |
| MAHLE / CLEVITE Fits: 4.2L L6 | K31757 | 🇺🇸 US 🇨🇦 CA | Beaded Steel | View on Amazon |
| MAHLE / CLEVITE Fits: 5.3L V8 | K31628 | 🇺🇸 US 🇨🇦 CA | Contains 2 GasketsMolded Rubber | View on Amazon |
| MELLING Fits: 5.3L V8 | MWPG500 | 🇺🇸 US 🇨🇦 CA | Contains 2 gaskets | View on Amazon |
| ULTRA-POWER Fits: 5.3L V8 | 35635 | 🇺🇸 US 🇨🇦 CA | Water Pump Mounting Gasket | View on Amazon |
| VICTOR REINZ Fits: 4.2L L6 | 711469100 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| VICTOR REINZ Fits: 5.3L V8 | 711468800 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| VICTOR REINZ Fits: 5.3L V8 | 181002001 | 🇺🇸 US 🇨🇦 CA | Mounting Set | View on Amazon |
This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
14 Water Pump Gasket parts are listed for the 2006 Isuzu Ascender, from FEL-PRO, VICTOR REINZ, GM GENUINE and 4 other brands. FEL-PRO ES73010 carries the "Popular" badge.
Water Pump Seal / O-Ring
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| APEX Fits: 5.3L V8 | AWP3151 | 🇺🇸 US 🇨🇦 CA | View on Amazon | |
| FEL-PRO Fits: 5.3L V8 | 35633 | 🇺🇸 US 🇨🇦 CA | O-Ring | View on Amazon |
| MAHLE / CLEVITE Fits: 5.3L V8 | K31629 | 🇺🇸 US 🇨🇦 CA | Water Pump Backing Plate GasketMolded Rubber | View on Amazon |
| VICTOR REINZ Fits: 5.3L V8 | 411041500 | 🇺🇸 US 🇨🇦 CA | View on Amazon |
This table covers the Water Pump Seal O-rings. Typical signs include a seep at a fitting or a housing that weeps after a service. Lube the new O-ring with the fluid it will see, and do not roll it into the groove.
4 Water Pump Seal / O-Ring parts for the 2006 Isuzu Ascender come from 4 brands — APEX, FEL-PRO, MAHLE / CLEVITE and 1 other brand.
This group includes APEX AWP3151, FEL-PRO 35633 and MAHLE / CLEVITE K31629 and the remaining parts above.
Buying Cooling System Parts for a 2006 Isuzu Ascender
On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.
- Match the engine first. Some cooling system parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Thermostat and Temperature Sender / Sensor .
Frequently Asked Questions
How many cooling system parts fit the 2006 Isuzu Ascender?
Our catalog currently lists 214 cooling system parts for the 2006 Isuzu Ascender across 25 subcategories and 46 brands, covering both the 4.2L L6 and the 5.3L V8. Each part is matched to the engine(s) it fits.
Do cooling system parts differ between 2006 Isuzu Ascender engines?
Some do. 48 parts fit every engine; the other 166 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of cooling system problems on a 2006 Isuzu Ascender?
Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2006 Isuzu Ascender was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2006 Isuzu Ascender?
First match the engine — each row shows which engine(s) the part fits. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2006 Isuzu Ascender
Cooling System Parts for Other Isuzu Ascender Years
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