The 2022 Lexus IS300 has 20 drivetrain parts with verified fitment on this page — 7 part types and 8 brands, covering both the 2.0L L4 Turbocharged and the 3.5L V6. Each part includes a manufacturer part number and application notes.
On the 2022 Lexus IS300, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. 12 parts of the 20 listed are CV Axle (7 parts), Gear Oil (3 parts) and Axle Shaft Seal (2 parts). The other 4 part types cover the remaining 8 parts.
The 2022 Lexus IS300 was sold with both the 2.0L L4 Turbocharged and the 3.5L V6. 15 parts fit every engine; the other 5 are engine-specific. Each part shows which engine(s) it fits.
8 brands supply drivetrain parts for the 2022 Lexus IS300, led by TIMKEN (4 parts), GSP (4 parts) and TOP NOTCH (3 parts), plus 5 more brands.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2022 Lexus IS300. 2 parts have it, including GSP NCV69100 (CV Axle) and TOP NOTCH TN18010 (CV Axle). Each part number opens a page with every vehicle that part fits.
Axle Shaft Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN Fits: all 2022 IS300 engines | SL260507 | 🇺🇸 US 🇨🇦 CA | Rear Left | View on Amazon |
| TIMKEN Fits: all 2022 IS300 engines | SL260508 | 🇺🇸 US 🇨🇦 CA | Rear Right | View on Amazon |
This table covers the seals where an axle shaft exits the housing. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
TIMKEN supplies both parts for the 2022 Lexus IS300. All of them fit every engine offered in the 2022 IS300.
Part numbers include TIMKEN SL260507 and TIMKEN SL260508.
CV Axle
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| GSP Popular Fits: 3.5L V6 | NCV69100 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
| TOP NOTCH Popular Fits: all 2022 IS300 engines | TN18010 | 🇺🇸 US 🇨🇦 CA | Rear Right | View on Amazon |
| GSP Fits: all 2022 IS300 engines | NCV69045 | 🇺🇸 US 🇨🇦 CA | Rear Right | View on Amazon |
| GSP Fits: all 2022 IS300 engines | NCV69250 | 🇺🇸 US 🇨🇦 CA | Rear Left | View on Amazon |
| GSP Fits: all 2022 IS300 engines | NCV69096 | 🇺🇸 US 🇨🇦 CA | Front Right | View on Amazon |
| TOP NOTCH Fits: all 2022 IS300 engines | TN18018 | 🇺🇸 US 🇨🇦 CA | Front Right | View on Amazon |
| TOP NOTCH Fits: 3.5L V6 | TN18021 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
This table covers the complete CV axle shafts from differential (or hub) to wheel. Typical signs include a click in tight turns, grease flung around the wheel well, or a vibration that builds with speed. A torn boot caught early is a boot kit; caught late it is the whole axle. Torque the axle nut to the method in the notes.
7 CV Axle parts are listed for the 2022 Lexus IS300, from GSP and TOP NOTCH. GSP NCV69100 carries the "Popular" badge. 5 parts fit every engine; the other 2 are engine-specific.
Part numbers include GSP NCV69100, TOP NOTCH TN18010 and GSP NCV69045, among others listed above.
Differential Fill / Drain Plug
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2022 IS300 engines | 991000CD | 🇺🇸 US 🇨🇦 CA | Front DifferentialAWD | View on Amazon |
| DORMAN Fits: all 2022 IS300 engines | 991000 | 🇺🇸 US 🇨🇦 CA | Front DifferentialAWD | View on Amazon |
This table covers the Differential Fill drain plugs.
DORMAN supplies both parts for the 2022 Lexus IS300. All of them fit every engine offered in the 2022 IS300.
Listed part numbers: DORMAN 991000CD and DORMAN 991000.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN Fits: all 2022 IS300 engines | SL260600 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
| TIMKEN Fits: all 2022 IS300 engines | SL260611 | 🇺🇸 US 🇨🇦 CA | Front | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
TIMKEN supplies both parts for the 2022 Lexus IS300. All of them fit every engine offered in the 2022 IS300.
This group includes TIMKEN SL260600 and TIMKEN SL260611.
Drive Shaft
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN Fits: all 2022 IS300 engines | 966410 | 🇺🇸 US 🇨🇦 CA | Length: 54.75" | View on Amazon |
| WJB / INMOTION PARTS Fits: all 2022 IS300 engines | WDS66410 | 🇺🇸 US 🇨🇦 CA | RearAWD | View on Amazon |
This table covers the driveshafts that carry torque from the transmission or transfer case.
2 Drive Shaft parts for the 2022 Lexus IS300 come from 2 brands — DORMAN and WJB / INMOTION PARTS. Every part fits both the 2.0L L4 Turbocharged and the 3.5L V6.
This group includes DORMAN 966410 and WJB / INMOTION PARTS WDS66410.
Drive Shaft Center Support Bearing
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| WESTAR Fits: all 2022 IS300 engines | DS6098 | 🇺🇸 US 🇨🇦 CA | AWDBearings ID: 1.181" (30mm) | View on Amazon |
| WESTAR Fits: all 2022 IS300 engines | DS6519 | 🇺🇸 US 🇨🇦 CA | RWDBearings I.D. = 1.181" (30mm) | View on Amazon |
This table covers the Drive Shaft Center Support bearings. Typical signs include a growl that rises with speed, or play in the shaft or hub. Set preload the way the notes specify. A dry or crushed bearing fails quickly.
2 Drive Shaft Center Support Bearing parts for the 2022 Lexus IS300 come from WESTAR. Every part fits both the 2.0L L4 Turbocharged and the 3.5L V6.
Listed part numbers: WESTAR DS6098 and WESTAR DS6519.
Gear Oil
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL Fits: 2.0L L4 Turbocharged | 104361 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-901 Quart | View on Amazon |
| VALVOLINE Fits: 2.0L L4 Turbocharged | 915052 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-85 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE Fits: 2.0L L4 Turbocharged | 915053 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-85 Gear Oil1 Quart Flex Fill | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
3 Gear Oil parts are listed for the 2022 Lexus IS300, from VALVOLINE and MOBIL.
This group includes MOBIL 104361, VALVOLINE 915052 and VALVOLINE 915053.
Buying Drivetrain Parts for a 2022 Lexus IS300
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Match the engine first. Some drivetrain parts fit every engine; others are engine-specific. Each row shows which engine(s) it fits.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: CV Axle and Gear Oil .
Frequently Asked Questions
How many drivetrain parts fit the 2022 Lexus IS300?
Our catalog currently lists 20 drivetrain parts for the 2022 Lexus IS300 across 7 subcategories and 8 brands, covering both the 2.0L L4 Turbocharged and the 3.5L V6. Each part is matched to the engine(s) it fits.
Do drivetrain parts differ between 2022 Lexus IS300 engines?
Some do. 15 parts fit every engine; the other 5 are engine-specific. Each row (and the filter at the top) shows which. If you're unsure which engine you have, check the emissions label under the hood or the 8th character of your VIN.
What are the signs of drivetrain problems on a 2022 Lexus IS300?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus IS300 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Lexus IS300?
First match the engine — each row shows which engine(s) the part fits. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Lexus IS300
Drivetrain Parts for Other Lexus IS300 Years
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