2022 Lexus RX450HL Cooling System Parts

Engine:
3.5L V6 ELECTRIC/GAS

The 2022 Lexus RX450HL has 62 cooling system parts with verified fitment on this page — 12 part types and 29 brands, covering the 3.5L V6 ELECTRIC/GAS engine. Each part includes a manufacturer part number and application notes.

The cooling system system on the 2022 Lexus RX450HL keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. The largest groups are Coolant / Antifreeze (16 parts), Water Pump (12 parts) and Radiator (6 parts). The other 9 part types cover the remaining 28 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE AF3055
🇺🇸 US 🇨🇦 CA
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
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Economy

Brand Part Number Markets Notes Buy
PEAK BQA1GAL
🇺🇸 US 🇨🇦 CA
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
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PRESTONE AF3100
🇺🇸 US 🇨🇦 CA
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
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Heavy Duty

Brand Part Number Markets Notes Buy
PRESTONE AFC12100
🇺🇸 US 🇨🇦 CA
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
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Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular AF2100
🇺🇸 US 🇨🇦 CA
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
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PEAK PKP1GAL
🇺🇸 US 🇨🇦 CA
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
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PEAK PXA1GAL
🇺🇸 US 🇨🇦 CA
Global Lifetime1 Gallon
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PRESTONE AF6210
🇺🇸 US 🇨🇦 CA
MAX Original EquipmentAsian Red/Pink
Fitment notes — PRESTONE AF6210
MAX Original EquipmentAsian Red/PinkReady To Use 1 Gallon
(Type: Prediluted)
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PRESTONE AFMAX
🇺🇸 US 🇨🇦 CA
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
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Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular ACT002
🇺🇸 US 🇨🇦 CA
PinkHOAT
Fitment notes — AISIN ACT002
PinkHOAT
(Type: Prediluted)
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BECK/ARNLEY Popular 2521502
🇺🇸 US 🇨🇦 CA
Premium Extra Life Pink
Fitment notes — BECK/ARNLEY 2521502
Premium Extra Life Pink
Fits:
ENGINE COOLANT
or:
Hybrid Drive Coolant
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VALVOLINE Popular 675130
🇺🇸 US 🇨🇦 CA
Asian Vehicle Red1 Gallon
Fitment notes — VALVOLINE 675130
Asian Vehicle Red1 GallonPOAT
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BECK/ARNLEY 2521002
🇺🇸 US 🇨🇦 CA
Premium Red
Fitment notes — BECK/ARNLEY 2521002
Premium Red
Fits:
Engine Coolant252-1502 Pink premix Can be used with or In place of Redor Hybrid Drive Coolant252-1502 Pink premix Can be used with or In place of Red (Type: Concentrated)
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PEAK PAR1GAL
🇺🇸 US 🇨🇦 CA
OET Asian Extended Life Red1 Gallon
Fitment notes — PEAK PAR1GAL
OET Asian Extended Life Red1 Gallon
OE Match, This product is compatible with Asian Red and pink antifreeze.
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PENTOSIN 8115209
🇺🇸 US 🇨🇦 CA
Pentofrost A41 Gallon
Fitment notes — PENTOSIN 8115209
Pentofrost A41 GallonPink
(Type: Prediluted)
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VALVOLINE 898406
🇺🇸 US 🇨🇦 CA
Hybrid Vehicle1 Gallon
Fitment notes — VALVOLINE 898406
Hybrid Vehicle1 Gallon
(Type: Prediluted)
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This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
CALORSTAT RC0145
🇺🇸 US 🇨🇦 CA
Attachment Type: Threaded
Fitment notes — CALORSTAT RC0145
Attachment Type: Threaded
with Inverter Reservoir
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GATES 31541
🇺🇸 US 🇨🇦 CA
OE TypeThreaded (Closed System) - (SAE Range 18-20 psi)
Fitment notes — GATES 31541
OE TypeThreaded (Closed System) - (SAE Range 18-20 psi)
Electric Motor Module16 psi Pressure Rating
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MOTORAD T51
🇺🇸 US 🇨🇦 CA
Standard
Fitment notes — MOTORAD T51
Standard
Relief Pressure 16 lbsInverter Cooling System
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This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Cooling Fan Control Module

Brand Part Number Markets Notes Buy
ACKOJA A70790004
🇺🇸 US 🇨🇦 CA
with OE No. 8925726020
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GATES FCM143
🇺🇸 US 🇨🇦 CA
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SKP SKFCM143
🇺🇸 US 🇨🇦 CA
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This table covers the Cooling Fan control modules.

Inverter Cooler

Brand Part Number Markets Notes Buy
TECHPRO TO3011107
🇺🇸 US 🇨🇦 CA
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This table covers the Inverter coolers. Typical signs include overheated fluid, a leak at the fittings, or mixed fluids in the reservoir. Flush the lines when you replace a cooler.

Radiator

Brand Part Number Markets Notes Buy
CSF Popular 3820
🇺🇸 US 🇨🇦 CA
1 Row11% Thicker Core 30mm vs OEM 27mm
Fitment notes — CSF 3820
1 Row11% Thicker Core 30mm vs OEM 27mmPlastic Tank / Aluminum Core
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DENSO Popular 2219596
🇺🇸 US 🇨🇦 CA
Radiator
Fitment notes — DENSO 2219596
Radiator
Auxiliary
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NISSENS 606544
🇺🇸 US 🇨🇦 CA
Engine Cooling
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SPECTRA PREMIUM CU13602
🇺🇸 US 🇨🇦 CA
Main Unit
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TYC 13596
🇺🇸 US 🇨🇦 CA
PRIMARY
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UAC RA13596C
🇺🇸 US 🇨🇦 CA
Downflow
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This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Locking Replacement

Brand Part Number Markets Notes Buy
MOTORAD ST37
🇺🇸 US 🇨🇦 CA
Safety LeverIndicator Markings Color: Silver
Fitment notes — MOTORAD ST37
Safety LeverIndicator Markings Color: Silver
Relief Pressure 16 lbsFor Engine Cooling
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Standard Replacement

Brand Part Number Markets Notes Buy
GATES Popular 31412
🇺🇸 US 🇨🇦 CA
OE Type
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CALORSTAT RC0040
🇺🇸 US 🇨🇦 CA
Includes 2 sealsMetallic
Fitment notes — CALORSTAT RC0040
Includes 2 sealsMetallicDegassing function
PSI - 20.0
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MOTORAD T37
🇺🇸 US 🇨🇦 CA
StandardIncludes Hose
Fitment notes — MOTORAD T37
StandardIncludes HoseIndicator Markings Color: Red, White, Yellow
Relief Pressure 16 lbsFor Engine Cooling
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SKP SK10242
🇺🇸 US 🇨🇦 CA
16 psi Pressure Rating
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This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Fan Assembly

Brand Part Number Markets Notes Buy
TECHPRO LX3115144
🇺🇸 US 🇨🇦 CA
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This table covers the fan assemblies (and clutches, where listed) that pull air through the radiator.

Radiator Hose

Brand Part Number Markets Notes Buy
GATES 51559
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 51559
Molded
Upper
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GATES 51562
🇺🇸 US 🇨🇦 CA
Molded
Fitment notes — GATES 51562
Molded
Lower
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This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
GPD 1814521
🇺🇸 US 🇨🇦 CA
Straight Connector
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Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular THSAZ8003
🇺🇸 US 🇨🇦 CA
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STANDARD MOTOR PRODUCTS Popular TX273
🇺🇸 US 🇨🇦 CA
View on
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BECK/ARNLEY 1581802
🇺🇸 US 🇨🇦 CA
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DELPHI TS10626
🇺🇸 US 🇨🇦 CA
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WALKER PRODUCTS 2112012
🇺🇸 US 🇨🇦 CA
Sensor Only
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This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
DORMAN 9025212
🇺🇸 US 🇨🇦 CA
Includes Housing
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Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular THT021
🇺🇸 US 🇨🇦 CA
82°C
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FOUR SEASONS 86321
🇺🇸 US 🇨🇦 CA
Includes Housing
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MAHLE / CLEVITE TI37682D
🇺🇸 US 🇨🇦 CA
Integral Thermostat
Fitment notes — MAHLE / CLEVITE TI37682D
Integral Thermostat
82Start to Open Temperature: with Seal
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MOTORAD 1040180
🇺🇸 US 🇨🇦 CA
Includes Housing, Seal
Fitment notes — MOTORAD 1040180
Includes Housing, Seal
180 Degrees FOE Specified Temperature
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This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
MAHLE / CLEVITE C33835
🇺🇸 US 🇨🇦 CA
Molded Rubber
Fitment notes — MAHLE / CLEVITE C33835
Molded Rubber
Water Outlet Seal
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MAHLE / CLEVITE C33837
🇺🇸 US 🇨🇦 CA
Engine Coolant Outlet O-RingMolded Rubber
Fitment notes — MAHLE / CLEVITE C33837
Engine Coolant Outlet O-RingMolded Rubber
Thermostat Housing Seal
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This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Water Pump

Economy

Brand Part Number Markets Notes Buy
US MOTOR WORKS Popular US8150
🇺🇸 US 🇨🇦 CA
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ACKOJA A70160013
🇺🇸 US 🇨🇦 CA
with OE No. G904052020Auxiliary
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BECK/ARNLEY 1312538
🇺🇸 US 🇨🇦 CA
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FVP US8150
🇺🇸 US 🇨🇦 CA
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SKP SK1703020
🇺🇸 US 🇨🇦 CA
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Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular WPT808
🇺🇸 US 🇨🇦 CA
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GATES Popular 43424
🇺🇸 US 🇨🇦 CA
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AISIN WQT005
🇺🇸 US 🇨🇦 CA
AuxiliaryInverter Cooler Water Pump
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DAYCO DP2182
🇺🇸 US 🇨🇦 CA
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FOUR SEASONS 89093
🇺🇸 US 🇨🇦 CA
AuxiliaryInverter Cooler Water Pump
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GMB 1703020
🇺🇸 US 🇨🇦 CA
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NISSENS 833793
🇺🇸 US 🇨🇦 CA
AuxiliaryInverter Cooler Water Pump
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This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Buying Cooling System Parts for a 2022 Lexus RX450HL

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Confirm you have the 3.5L V6 ELECTRIC/GAS engine — every part on this page is matched to it.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Coolant / Antifreeze and Water Pump .

Frequently Asked Questions

How many cooling system parts fit the 2022 Lexus RX450HL?

Our catalog currently lists 62 cooling system parts for the 2022 Lexus RX450HL across 12 subcategories and 29 brands, covering the 3.5L V6 ELECTRIC/GAS engine. Each part is matched to the engine(s) it fits.

What are the signs of cooling system problems on a 2022 Lexus RX450HL?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus RX450HL was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2022 Lexus RX450HL?

Every part on this page is matched to the 3.5L V6 ELECTRIC/GAS engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2022 Lexus RX450HL

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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.