The 2022 Lexus RX450HL has 19 drivetrain parts with verified fitment on this page — 4 part types and 9 brands, covering the 3.5L V6 ELECTRIC/GAS engine. Each part includes a manufacturer part number and application notes.
The drivetrain system on the 2022 Lexus RX450HL moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. The largest groups are Gear Oil (10 parts), CV Axle (6 parts) and Axle Shaft Seal (2 parts). The other 1 part type covers the remaining 1 part.
The 2022 Lexus RX450HL came with a single engine, the 3.5L V6 ELECTRIC/GAS, and every part is verified against it.
9 brands supply drivetrain parts for the 2022 Lexus RX450HL, led by VALVOLINE (4 parts), TRAKMOTIVE (3 parts) and TIMKEN (2 parts), plus 6 more brands.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2022 Lexus RX450HL. 4 parts have it, including TOP NOTCH TN18016 (CV Axle) and ACDELCO 109243 (Gear Oil). Each part number opens a page with every vehicle that part fits.
Axle Shaft Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TIMKEN | SL260419 | 🇺🇸 US 🇨🇦 CA | Rear Left | View on Amazon |
| TIMKEN | SL260433 | 🇺🇸 US 🇨🇦 CA | Rear Right | View on Amazon |
This table covers the seals where an axle shaft exits the housing. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
TIMKEN supplies both parts for the 2022 Lexus RX450HL.
Listed part numbers: TIMKEN SL260419 and TIMKEN SL260433.
CV Axle
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| TOP NOTCH Popular | TN18016 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
| TRAKMOTIVE Popular | TO8163 | 🇺🇸 US 🇨🇦 CA | Front LeftNorth America Built | View on Amazon |
| GSP | NCV69091 | 🇺🇸 US 🇨🇦 CA | Front Left | View on Amazon |
| GSP | NCV69265 | 🇺🇸 US 🇨🇦 CA | Axle Nut Type: Bihexagonal | View on Amazon |
| TRAKMOTIVE | TO8395 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
| TRAKMOTIVE | TO8409 | 🇺🇸 US 🇨🇦 CA | AAR Joint Design | View on Amazon |
This table covers the complete CV axle shafts from differential (or hub) to wheel. Typical signs include a click in tight turns, grease flung around the wheel well, or a vibration that builds with speed. A torn boot caught early is a boot kit; caught late it is the whole axle. Torque the axle nut to the method in the notes.
6 CV Axle parts are listed for the 2022 Lexus RX450HL, from TRAKMOTIVE, GSP and TOP NOTCH. TOP NOTCH TN18016 carries the "Popular" badge.
Part numbers include TOP NOTCH TN18016, TRAKMOTIVE TO8163 and GSP NCV69091, among others listed above.
Gear Oil
ATF 64
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| PENTOSIN | 1058113 | 🇺🇸 US 🇨🇦 CA | 1 LiterATF64 or ATF44 | View on Amazon |
| PENTOSIN | 1058215 | 🇺🇸 US 🇨🇦 CA | 5 LitersATF64 or ATF44 | View on Amazon |
Dexron
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ACDELCO Popular | 109243 | 🇺🇸 US | Container Type: Plastic Container | View on Amazon |
Multi-Vehicle
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VALVOLINE Popular | VV3246 | 🇺🇸 US 🇨🇦 CA | Max Life Multi-Vehicle or Maxlife Multi-Vehicle Full Synthetic ATF1 Quart | View on Amazon |
| LUCAS OIL | 11255 | 🇺🇸 US 🇨🇦 CA | LOW VISCOSITY SYNTHETIC MULTI-VEHICLE AUTOMATIC TRANSMISSION FLUID1 qt | View on Amazon |
| LUCAS OIL | 18037 | 🇺🇸 US 🇨🇦 CA | Low Viscosity Synthetic Multi-Vehicle Automatic Transmission Fluid6 Gallon | View on Amazon |
| MOBIL | 126505 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle ATF | View on Amazon |
| VALVOLINE | 773775 | 🇺🇸 US 🇨🇦 CA | Max Life Multi-Vehicle or Maxlife Multi-Vehicle Full Synthetic ATF1 Gallon | View on Amazon |
| VALVOLINE | 881051 | 🇺🇸 US 🇨🇦 CA | Maxlife Multi-Vehicle Full Synthetic ATF5 Gallon Bay Box | View on Amazon |
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| VALVOLINE | 899179 | 🇺🇸 US 🇨🇦 CA | Extended Protection Full Synthetic ATF1 Quart | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
10 Gear Oil parts are listed for the 2022 Lexus RX450HL, from VALVOLINE, PENTOSIN, LUCAS OIL and 2 other brands. ACDELCO 109243 carries the "Popular" badge.
The ATF 64 section lists 2 options from PENTOSIN — grouped under the catalog's "ATF 64" designation — the notes column spells out what sets them apart. PENTOSIN 1058113 is listed in this group.
In the Dexron grade, ACDELCO supplies 1 part: grouped under the catalog's "Dexron" designation — the notes column spells out what sets them apart. A representative part number is ACDELCO 109243.
In the Multi-Vehicle grade, VALVOLINE, LUCAS OIL and MOBIL supply 6 parts: grouped under the catalog's "Multi-Vehicle" designation — the notes column spells out what sets them apart. A representative part number is VALVOLINE VV3246.
1 ungrouped part is not assigned to a grade, with the same engine-level match.
Transfer Case Fluid
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL | 126505 | 🇺🇸 US 🇨🇦 CA | Multi-Vehicle ATF | View on Amazon |
This table covers the fluids specified for the transfer case. Typical signs include discolored fluid, a burnt smell, or a level that keeps dropping. Use only the specification in the notes — the tables group grades because they are not interchangeable.
One part is listed for the 2022 Lexus RX450HL — MOBIL 126505.
Buying Drivetrain Parts for a 2022 Lexus RX450HL
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 3.5L V6 ELECTRIC/GAS engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Gear Oil and CV Axle .
Frequently Asked Questions
How many drivetrain parts fit the 2022 Lexus RX450HL?
Our catalog currently lists 19 drivetrain parts for the 2022 Lexus RX450HL across 4 subcategories and 9 brands, covering the 3.5L V6 ELECTRIC/GAS engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2022 Lexus RX450HL?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Lexus RX450HL was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Lexus RX450HL?
Every part on this page is matched to the 3.5L V6 ELECTRIC/GAS engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Lexus RX450HL
Switch vehicle or jump to a subcategory
Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.