2021 Toyota Sequoia Cooling System Parts

Engine:
5.7L V8

The 2021 Toyota Sequoia has 97 cooling system parts with verified fitment on this page — 16 part types and 40 brands, covering the 5.7L V8 engine. Each part includes a manufacturer part number and application notes.

On the 2021 Toyota Sequoia, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses. 42 parts of the 97 listed are Coolant / Antifreeze (18 parts), Temperature Sender / Sensor (14 parts) and Thermostat (10 parts). The other 13 part types cover the remaining 55 parts.

Coolant / Antifreeze

Compatible With All Colors

Brand Part Number Markets Notes Buy
PRESTONE AF3055
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Prime YellowAll Vehicles
Fitment notes — PRESTONE AF3055
Prime YellowAll VehiclesExtended Life55 GAL DrumConcentratePrime® Extended Life All Makes All Models
View on
Amazon

Economy

Brand Part Number Markets Notes Buy
FVP Popular MV5050GAL
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Extended LifeAll Makes / All Models
Fitment notes — FVP MV5050GAL
Extended LifeAll Makes / All Models1 Gallon
View on
Amazon
PEAK BQA1GAL
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Blue Mountain Long LifeAll Vehicle
Fitment notes — PEAK BQA1GAL
Blue Mountain Long LifeAll Vehicle1 Gallon
The OE antifreeze color For this application Can be Red or pink.
View on
Amazon
PRESTONE AF3100
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Prime Yellow - All VehiclesExtended Life
Fitment notes — PRESTONE AF3100
Prime Yellow - All VehiclesExtended Life1 Gallon
View on
Amazon
VALVOLINE 719009
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Multi-Vehicle Yellow1 Gallon
View on
Amazon

Heavy Duty

Brand Part Number Markets Notes Buy
PRESTONE AFC12100
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT
Fitment notes — PRESTONE AFC12100
Command Nitrite Free Extended Life CoolantYellow Nitrite Free OAT1 GAL Ready To Use 50/50
Heavy Duty & Mixed Fleet Nitrite Free Extended Life CoolantYellow Fluid Class 1 - 8
View on
Amazon

Premium

Brand Part Number Markets Notes Buy
PRESTONE Popular AF2100
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
All Vehicles10yr/300k mi
Fitment notes — PRESTONE AF2100
All Vehicles10yr/300k mi1 GallonExtended Life
View on
Amazon
PEAK PKP1GAL
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
All Vehicles Antifreeze1 Gallon
Fitment notes — PEAK PKP1GAL
All Vehicles Antifreeze1 GallonPREMIUM1 GALLON10X MORE SCALE FIGHTING INHIBITORS10 YEAR/300K MILES
The OE antifreeze color For this application Can be Red or pink.
View on
Amazon
PEAK PXA1GAL
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Global Lifetime1 Gallon
Fitment notes — PEAK PXA1GAL
Global Lifetime1 Gallon
The OE antifreeze color For this application Can be Red or pink.
View on
Amazon
PRESTONE AF6210
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
MAX Original EquipmentAsian Red/Pink
Fitment notes — PRESTONE AF6210
MAX Original EquipmentAsian Red/PinkReady To Use 1 Gallon
(Type: Prediluted)
View on
Amazon
PRESTONE AFMAX
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Max Universal1 Gallon
Fitment notes — PRESTONE AFMAX
Max Universal1 Gallon15 Year/350k Miles
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular ACT002
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
PinkHOAT
Fitment notes — AISIN ACT002
PinkHOAT
(Type: Prediluted)
View on
Amazon
VALVOLINE Popular 675130
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Asian Vehicle Red1 Gallon
Fitment notes — VALVOLINE 675130
Asian Vehicle Red1 GallonPOAT
View on
Amazon
AISIN ACT002C
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Pink - Canada OnlyHOAT
View on
Amazon
BECK/ARNLEY 2521502
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Premium Extra Life Pink
Fitment notes — BECK/ARNLEY 2521502
Premium Extra Life Pink
(Type: Prediluted)
View on
Amazon
BECK/ARNLEY 2521002
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Premium Red
Fitment notes — BECK/ARNLEY 2521002
Premium Red
252-1502 Pink premix Can be used with or In place of Red (Type: Concentrated)
View on
Amazon
PEAK PAR1GAL
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
OET Asian Extended Life Red1 Gallon
Fitment notes — PEAK PAR1GAL
OET Asian Extended Life Red1 Gallon
The OE antifreeze color For this application Can be Red or pink.OE Match, This product is compatible with Asian Red and pink antifreeze.
View on
Amazon
PENTOSIN 8115209
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Pentofrost A41 Gallon
Fitment notes — PENTOSIN 8115209
Pentofrost A41 GallonPink
(Type: Prediluted)
View on
Amazon

This table covers the engine coolants and antifreeze formulations specified for this cooling system. Typical signs include a rising temperature gauge, rusty or sludged coolant, or a heater that blows cold. Use the chemistry named in the notes. Mixing silicate, OAT and HOAT formulas can gel in the radiator.

Coolant Hose / Pipe

Brand Part Number Markets Notes Buy
DORMAN 9365502
🇺🇸 US 🇨🇦 CA
Pipe
Fitment notes — DORMAN 9365502
Pipe
LowerHeater Tube AssemblyTo Sleeper Cab Heater
View on
Amazon

This table covers the hard pipes and extra hoses in the coolant circuit.

Coolant Reservoir Cap

Brand Part Number Markets Notes Buy
MOTORAD T166
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Standard
View on
Amazon

This table covers the caps on the overflow / expansion tank. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator

Economy

Brand Part Number Markets Notes Buy
GPD 13549C
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
CSF Popular 3776
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
DENSO 2219623
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
NISSENS 606523
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Brazed cooling fins
View on
Amazon
UAC RA13549C
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Downflow
View on
Amazon

This table covers the radiators that dump engine heat to airflow through the core. Typical signs include overheating in traffic, a wet core, or coolant that disappears with no puddle. Replace the cap if it cannot hold the rated pressure, and bleed the system after the swap.

Radiator Cap

Locking Replacement

Brand Part Number Markets Notes Buy
MOTORAD ST37
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Safety LeverIndicator Markings Color: Silver
Fitment notes — MOTORAD ST37
Safety LeverIndicator Markings Color: Silver
Relief Pressure 16 lbs
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
GATES Popular 31412
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
OE Type
View on
Amazon
CALORSTAT RC0040
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes 2 sealsMetallic
Fitment notes — CALORSTAT RC0040
Includes 2 sealsMetallicDegassing function
Fits:
4WDBody code USK65LPSI - 20.0or RWDBody code USK60LPSI - 20.0
View on
Amazon
MOTORAD T37
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
StandardIncludes Hose
Fitment notes — MOTORAD T37
StandardIncludes HoseIndicator Markings Color: Red, White, Yellow
Relief Pressure 16 lbs
View on
Amazon
SKP SK10242
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
16 psi Pressure Rating
View on
Amazon

This table covers the caps that hold system pressure at the radiator or reservoir neck. Typical signs include a leak at the neck, a cap that will not hold pressure, or a missing tether. Match the pressure rating or thread in the notes — radiator, reservoir and fuel caps are not interchangeable.

Radiator Fan Blade

Brand Part Number Markets Notes Buy
AISIN FNT031
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
8-Blade
View on
Amazon
DORMAN 620573
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
GPD 2812330
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
SKP SK38070
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon

This table covers the Radiator Fan blades. Typical signs include chatter, streaks, or a skip at the top of the stroke. Confirm left and right lengths in the notes — they are often different.

Radiator Fan Clutch

Brand Part Number Markets Notes Buy
HAYDEN Popular 6630
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
ThermalSevere Duty
Fitment notes — HAYDEN 6630
ThermalSevere Duty
Counter Clockwise
View on
Amazon
US MOTOR WORKS Popular 22408
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermal
View on
Amazon
FOUR SEASONS 46091
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Severe Duty Thermal
Fitment notes — FOUR SEASONS 46091
Severe Duty Thermal
Counter Clockwise
View on
Amazon
FVP 22408
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermal
Fitment notes — FVP 22408
Thermal
Clockwise Rotation
View on
Amazon
FVP 9702140
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermal
Fitment notes — FVP 9702140
Thermal
Counter Clockwise (Reverse) Rotation
View on
Amazon
GMB 9702140
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermal
Fitment notes — GMB 9702140
Thermal
Counter Clockwise (Reverse) Rotation
View on
Amazon
NISSENS 86433
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Severe Duty Thermal
Fitment notes — NISSENS 86433
Severe Duty Thermal
Counter Clockwise
View on
Amazon

This table covers the Radiator Fan clutches. Typical signs include slip at highway speed, chatter on takeoff, or a pedal that stays low. Resurface or replace the flywheel with the clutch — a heat-checked flywheel wastes the new disc.

Radiator Fan Shroud

Brand Part Number Markets Notes Buy
DORMAN 603049
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Shroud Assembly
View on
Amazon
TECHPRO TO3110187
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
VDO / CONTINENTAL FA74093
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
with Built in Reservoir
View on
Amazon

This table covers the shrouds that duct air through the fan and radiator.

Radiator Hose

Brand Part Number Markets Notes Buy
GATES Popular 23309
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Molded
Fitment notes — GATES 23309
Molded
Upper
View on
Amazon
GATES Popular 23310
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Molded
Fitment notes — GATES 23310
Molded
Lower
View on
Amazon
ACDELCO 22601M
🇺🇸 US 🇨🇦 CA
Professional / GoldMolded
Fitment notes — ACDELCO 22601M
Professional / GoldMolded
Upper
View on
Amazon
ACDELCO 24616L
🇺🇸 US 🇨🇦 CA
Professional / GoldMolded
Fitment notes — ACDELCO 24616L
Professional / GoldMolded
Lower
View on
Amazon
CONTINENTAL 66206
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Molded
Fitment notes — CONTINENTAL 66206
Molded
Upper
View on
Amazon
CONTINENTAL 66207
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Molded
Fitment notes — CONTINENTAL 66207
Molded
Lower
View on
Amazon
DAYCO 71827
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Curved
Fitment notes — DAYCO 71827
Curved
Upper
View on
Amazon
DAYCO 72271
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Curved
Fitment notes — DAYCO 72271
Curved
Lower
View on
Amazon

This table covers the upper, lower and connecting hoses between radiator, engine and reservoir. Typical signs include swelling, cracks, a soft spot, or a leak at a clamp. Replace adjacent aged hoses while the system is drained — they share the same heat cycle.

Temperature Sender / Sensor

Economy

Brand Part Number Markets Notes Buy
ULTRA-POWER Popular 5S1616
🇺🇸 US 🇨🇦 CA
View on
Amazon
GPD 1712514
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
HOLSTEIN 2CTS0051
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
UNITED MOTOR PRODUCTS CTS25
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Rectangular Connector
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
DELPHI Popular TS10289
🇺🇸 US 🇨🇦 CA
View on
Amazon
STANDARD MOTOR PRODUCTS Popular TX40
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Rectangular Connector2 Terminal
View on
Amazon
ACDELCO D583
🇺🇸 US 🇨🇦 CA
Gold
Fitment notes — ACDELCO D583
Gold
Alternate Replacement Part
View on
Amazon
BECK/ARNLEY 1581585
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
DENSO 1931000
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Engine Coolant Temperature Sensor
Fitment notes — DENSO 1931000
Engine Coolant Temperature Sensor
Fits:
4WDBody code USK65L
or:
RWDBody code USK60L
View on
Amazon
FACET 73323
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
NTK EF0157
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
STANDARD MOTOR PRODUCTS TX109
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
WALKER PRODUCTS 2111060
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Sensor Only
View on
Amazon
WELLS 5S1616
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Connector Shape: Rectangular
View on
Amazon

This table covers the senders that report coolant temperature to the gauge or ECU. Typical signs include a gauge that sits on empty or overheat, or a lamp that does not match what the engine is doing. Rule out the cluster and the wiring before replacing the sender.

Thermostat

Economy

Brand Part Number Markets Notes Buy
AUTOTECNICA TY0715902PRM
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
ÜRO SolutionsHeavy Duty Aluminum Upgrade
Fitment notes — AUTOTECNICA TY0715902PRM
ÜRO SolutionsHeavy Duty Aluminum Upgrade
Premium Aluminum Construction vs OE Plastic
View on
Amazon
DORMAN 9025136
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes Housing
View on
Amazon
SKP SK9025136
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes Housing
Fitment notes — SKP SK9025136
Includes Housing
Cover
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
AISIN Popular THT005
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
82°C
View on
Amazon
MOTORAD Popular 637180
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes Housing, Seal
Fitment notes — MOTORAD 637180
Includes Housing, Seal
180 Degrees FOE Specified Temperature
View on
Amazon
ACKOJA A70990020
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Limited or Platinum or SR5 ModelOpening Temperature: 82 °C
Fitment notes — ACKOJA A70990020
Limited or Platinum or SR5 ModelOpening Temperature: 82 °Cwith OE No. 160310S010, 1603138010
View on
Amazon
BECK/ARNLEY 1430920
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
TEMPERATURE 82C/180F
View on
Amazon
CALORSTAT TH731782J
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
180.0 Degrees
View on
Amazon
FOUR SEASONS 85953
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes Housing
View on
Amazon
GATES 34705
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Integrated Housing Thermostat
Fitment notes — GATES 34705
Integrated Housing Thermostat
180 DegreeOE TemperatureSeal Included
View on
Amazon

This table covers the thermostats that open the coolant circuit at the specified temperature. Typical signs include slow warm-up, a gauge that climbs in traffic, or heat that never quite arrives. Replace the housing gasket with the thermostat and bleed the system so a trapped air pocket does not cook the new part.

Thermostat / Thermostat Housing / Water Outlet Seal

Brand Part Number Markets Notes Buy
APEX AWO2327
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermostat Seal
View on
Amazon
APEX AWO2272
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Water Outlet Seal
View on
Amazon
FEL-PRO 35891
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Thermostat Housing Seal
View on
Amazon
FEL-PRO 35886
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Water Outlet Seal
View on
Amazon

This table covers the seals at the thermostat housing and water outlet. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.

Thermostat Housing / Water Outlet

Economy

Brand Part Number Markets Notes Buy
ULTRA-POWER 9025136
🇺🇸 US 🇨🇦 CA
AssemblyIncludes Thermostat
Fitment notes — ULTRA-POWER 9025136
AssemblyIncludes Thermostat
Cover
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
MOTORAD CH1044
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Fits Lowerwith Towing Package
Fitment notes — MOTORAD CH1044
Fits:
Lowerwith Towing PackageWater Outlet
or:
Lowerwith Towing PackageThermostat Housing
View on
Amazon
MOTORAD CH1043
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Fits Lowerwithout Towing Package
Fitment notes — MOTORAD CH1043
Fits:
Lowerwithout Towing PackageWater Outlet
or:
Lowerwithout Towing PackageThermostat Housing
View on
Amazon

This table covers the housings and outlets the thermostat sits in.

Water Inlet Gasket

Brand Part Number Markets Notes Buy
APEX AWO2273
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
FEL-PRO 35893
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon

This table covers the gaskets that seal the Water Inlet. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Water Pump

Economy

Brand Part Number Markets Notes Buy
BECK/ARNLEY 1312403
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Metal Impeller
View on
Amazon
FVP US6197
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
SKP SK1704000
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
US MOTOR WORKS US6197
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon

Standard Replacement

Brand Part Number Markets Notes Buy
ACDELCO Popular 252951
🇺🇸 US 🇨🇦 CA
GoldDoes Not Include Mount Bolts
View on
Amazon
AISIN Popular WPT804
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Includes Gasket
View on
Amazon
DAYCO DP1437
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
Serpentine Belt Driven
View on
Amazon
GATES 42290
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
GMB 1704000
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon

This table covers the pumps that circulate coolant through the block and radiator. Typical signs include coolant at the weep hole, pulley play, or a growl from the front of the engine. Replace the thermostat and refill with the specified coolant whenever the pump comes off.

Water Pump Gasket

Brand Part Number Markets Notes Buy
AJUSA 01699800
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
APEX AWP3230
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
View on
Amazon
FEL-PRO 35889
🇺🇸 US 🇨🇦 CA 🇲🇽 MX
To Block
View on
Amazon

This table covers the gaskets between the water pump and the block or housing. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.

Buying Cooling System Parts for a 2021 Toyota Sequoia

On this vehicle, the cooling system system keeps operating temperature in the narrow band the engine was designed for, from radiator and water pump to thermostat and hoses.

  • Confirm you have the 5.7L V8 engine — every part on this page is matched to it.
  • Read the notes on each row for position, trim and spec qualifiers before you order.
  • Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.
  • Cross-reference the manufacturer part number against your old part or a service-manual listing.

Start with the largest groups on this page: Coolant / Antifreeze and Temperature Sender / Sensor .

Frequently Asked Questions

How many cooling system parts fit the 2021 Toyota Sequoia?

Our catalog currently lists 97 cooling system parts for the 2021 Toyota Sequoia across 16 subcategories and 40 brands, covering the 5.7L V8 engine. Each part is matched to the engine(s) it fits.

What are the signs of cooling system problems on a 2021 Toyota Sequoia?

Common symptoms include a rising temperature gauge in traffic, sweet-smelling steam, crusty deposits around hose clamps, or a heater that blows cold. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.

What should I replace at the same time?

Where labor overlaps, replace the thermostat and refill with fresh coolant whenever you change a water pump or radiator; original hoses on an older vehicle are on borrowed time.

What do the market flags (US, CA, MX) on each part mean?

They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2021 Toyota Sequoia was originally sold in the US, the safest choice is a part marked for the US market.

How do I make sure a part fits my 2021 Toyota Sequoia?

Every part on this page is matched to the 5.7L V8 engine. Then replace coolant with the exact specification the manufacturer calls for — mixing chemistries can gel and block small passages. The notes column carries position and trim qualifiers where they apply.

Other Parts for the 2021 Toyota Sequoia

Cooling System Parts for Other Toyota Sequoia Years

Switch vehicle or jump to a subcategory

Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.