The 2022 Ford E-350 has 21 drivetrain parts with verified fitment on this page — 7 part types and 5 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.
On the 2022 Ford E-350, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. Most of the listed parts are Axle Shaft (8 parts), Differential Carrier (4 parts) and Differential Pinion Seal (3 parts). The other 4 part types cover the remaining 6 parts.
Every part on this page is matched to the 7.3L V8 — the only engine offered in the 2022 Ford E-350.
The most listed brands for 2022 Ford E-350 drivetrain parts are DANA (16 parts), MOTIVE GEAR (2 parts) and DORMAN (1 part), plus 2 more brands.
2 parts on this 2022 Ford E-350 page carry a "Popular" badge — the source catalog's flag for options frequently chosen for this vehicle — including DANA 438117 (Axle Shaft) and DANA 760022X (Axle Shaft). Click any part number to see every vehicle that part fits.
Axle Shaft
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA Popular | 438117 | 🇺🇸 US 🇨🇦 CA | SpicerLength: 40.75 | View on Amazon |
| DANA Popular | 760022X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 34.08 | View on Amazon |
| DANA | 438114 | 🇺🇸 US 🇨🇦 CA | SpicerLength: 37.40 | View on Amazon |
| DANA | 753441X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 31.41 | View on Amazon |
| DANA | 753442X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 34.13 | View on Amazon |
| DANA | 760021X | 🇺🇸 US 🇨🇦 CA | SpicerLength: 31.36 | View on Amazon |
| MOTIVE GEAR | 753441XR | 🇺🇸 US 🇨🇦 CA | Rear RightDana 60 Standard Differential | View on Amazon |
| MOTIVE GEAR | 753442XR | 🇺🇸 US 🇨🇦 CA | Rear LeftDana 60 Standard Differential | View on Amazon |
This table covers the Axle shafts.
8 Axle Shaft parts are listed for the 2022 Ford E-350, from DANA and MOTIVE GEAR. DANA 438117 carries the "Popular" badge.
Listed part numbers: DANA 438117, DANA 760022X and DANA 438114, plus the other parts above.
Axle Shaft Flange Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 926880 | 🇺🇸 US 🇨🇦 CA | RearOver 7,700 Lb. GVW | View on Amazon |
This table covers the gaskets that seal the Axle Shaft Flange. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
One part is listed for the 2022 Ford E-350 — DORMAN 926880.
Differential Carrier
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7072161X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 2005750 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 7072121X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 7080761 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the carriers that hold the differential gears in the axle.
4 Differential Carrier parts for the 2022 Ford E-350 come from DANA.
Part numbers include DANA 7072161X, DANA 2005750 and DANA 7072121X, among others listed above.
Differential Carrier Bearing / Race
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 566079 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 566080 | 🇺🇸 US 🇨🇦 CA | FSGRRace | View on Amazon |
This table covers the bearings and races that support the differential carrier.
2 Differential Carrier Bearing / Race parts for the 2022 Ford E-350 come from DANA.
This group includes DANA 566079 and DANA 566080.
Differential Cover
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7071051X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 20065041 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Differential covers.
DANA supplies both parts for the 2022 Ford E-350.
This group includes DANA 7071051X and DANA 20065041.
Differential Pinion Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 2010948 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the flanges that connect the driveshaft to the differential pinion.
This group shows a single part: DANA 2010948.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 50637 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| SCHAEFFLER | SS2923 | 🇺🇸 US 🇨🇦 CA | Rear Outer3.21" O.D. X 0.5" Width | View on Amazon |
| TIMKEN | 100715V | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
3 Differential Pinion Seal parts for the 2022 Ford E-350 come from 3 brands — DANA, SCHAEFFLER and TIMKEN.
Part numbers include DANA 50637, SCHAEFFLER SS2923 and TIMKEN 100715V.
Buying Drivetrain Parts for a 2022 Ford E-350
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Axle Shaft and Differential Carrier .
Frequently Asked Questions
How many drivetrain parts fit the 2022 Ford E-350?
Our catalog currently lists 21 drivetrain parts for the 2022 Ford E-350 across 7 subcategories and 5 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2022 Ford E-350?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2022 Ford E-350 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2022 Ford E-350?
Every part on this page is matched to the 7.3L V8 engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2022 Ford E-350
Drivetrain Parts for Other Ford E-350 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.