The 2025 Ford E-350 has 24 drivetrain parts with verified fitment on this page — 8 part types and 7 brands, covering the 7.3L V8 engine. Each part includes a manufacturer part number and application notes.
On the 2025 Ford E-350, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware. 17 parts of the 24 listed are Gear Oil (12 parts), Drive Shaft Center Support Bearing (3 parts) and Differential Cover (2 parts). The other 5 part types cover the remaining 7 parts.
The 2025 Ford E-350 came with a single engine, the 7.3L V8, and every part is verified against it.
7 brands supply drivetrain parts for the 2025 Ford E-350, led by VALVOLINE (10 parts), DANA (6 parts) and DORMAN (2 parts), plus 4 more brands. Quality grades include Standard Replacement, Economy and Heavy Duty.
A "Popular" badge means the source catalog flagged the part as frequently chosen for the 2025 Ford E-350. 3 parts have it, including MOBIL 104361 (Gear Oil) and VALVOLINE VV820 (Gear Oil). Each part number opens a page with every vehicle that part fits.
Axle Shaft Flange Gasket
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 926880 | 🇺🇸 US 🇨🇦 CA | RearOver 7,700 Lb. GVW | View on Amazon |
This table covers the gaskets that seal the Axle Shaft Flange. Typical signs include seepage at the joint, a burnt-oil smell, or a leak that appears only after a long drive. Clean both flanges and torque in the sequence the notes or the manual call for.
This group shows a single part: DORMAN 926880.
Differential Cover
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 7071051X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| DANA | 20065041 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Differential covers.
2 Differential Cover parts for the 2025 Ford E-350 come from DANA.
This group includes DANA 7071051X and DANA 20065041.
Differential Pinion Flange
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 2010948 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the flanges that connect the driveshaft to the differential pinion.
One part is listed for the 2025 Ford E-350 — DANA 2010948.
Differential Pinion Seal
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 50637 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
| SCHAEFFLER | SS2923 | 🇺🇸 US 🇨🇦 CA | Rear Outer3.21" O.D. X 0.5" Width | View on Amazon |
This table covers the seals at the differential pinion yoke. Typical signs include a wet housing, a drip after sitting, or fluid flung off a rotating shaft. Fix the surface the seal rides on. A new seal on a grooved shaft will leak again.
2 Differential Pinion Seal parts are listed for the 2025 Ford E-350, from DANA and SCHAEFFLER.
Listed part numbers: DANA 50637 and SCHAEFFLER SS2923.
Drive Shaft Center Support Bearing
Economy
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DORMAN | 934007 | 🇺🇸 US 🇨🇦 CA | Rear | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| ANCHOR | 6053 | 🇺🇸 US 🇨🇦 CA | Centerwithout Mounting Studs | View on Amazon |
| DANA | 211359X | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Drive Shaft Center Support bearings. Typical signs include a growl that rises with speed, or play in the shaft or hub. Set preload the way the notes specify. A dry or crushed bearing fails quickly.
3 Drive Shaft Center Support Bearing parts for the 2025 Ford E-350 come from 3 brands — DORMAN, ANCHOR and DANA.
The Economy section lists 1 option from DORMAN — the catalog's value-priced group. DORMAN 934007 is listed in this group.
In the Standard Replacement grade, ANCHOR and DANA supply 2 parts: built to original-equipment specification. A representative part number is ANCHOR 6053.
Part numbers include DORMAN 934007, ANCHOR 6053 and DANA 211359X.
Drive Shaft Flange Yoke
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| DANA | 321839 | 🇺🇸 US 🇨🇦 CA | Spicer | View on Amazon |
This table covers the Drive Shaft Flange yokes.
One part is listed for the 2025 Ford E-350 — DANA 321839.
Gear Oil
SAE 75W-140
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL | 102490 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-14 0Mobil 1 Synthetic Gear Lubricant LS 75W-14 0 | View on Amazon |
| VALVOLINE | VV982 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil1 Quart | View on Amazon |
| VALVOLINE | 889787 | 🇺🇸 US 🇨🇦 CA | Full Synthetic SAE 75W-14 0 Gear Oil1 Quart Flex Fill | View on Amazon |
| VALVOLINE | 887344 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE | VV981 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-14 0 Gear Oil5 Gallon | View on Amazon |
SAE 75W-90
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOBIL Popular | 104361 | 🇺🇸 US 🇨🇦 CA | Synthetic Gear Lube Limited Slip 75W-901 Quart | View on Amazon |
| VALVOLINE Popular | VV820 | 🇺🇸 US 🇨🇦 CA | Daily Protection SAE 75W-90 Gear Oil1 Quart | View on Amazon |
| VALVOLINE Popular | VV975 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil1 Quart | View on Amazon |
| VALVOLINE | 889785 | 🇺🇸 US 🇨🇦 CA | Full Synthetic SAE 75W-90 Gear Oil1 Quart Flex Fill | View on Amazon |
| VALVOLINE | 882505 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil1 Gallon | View on Amazon |
| VALVOLINE | 723856 | 🇺🇸 US 🇨🇦 CA | Advanced Full Synthetic SAE 75W-90 Gear Oil5 Gallon | View on Amazon |
| VALVOLINE | VV822 | 🇺🇸 US 🇨🇦 CA | Daily Protection SAE 75W-90 Gear Oil16 Gallon KEG | View on Amazon |
This table covers the gear oils specified for the axle or transfer case. Typical signs include a low-oil lamp, knocking, or oil that has gone thin before the next interval. Match the viscosity and spec in the notes, not just the weight on the bottle.
12 Gear Oil parts are listed for the 2025 Ford E-350, from VALVOLINE and MOBIL. MOBIL 104361 carries the "Popular" badge.
In the SAE 75W-140 grade, VALVOLINE and MOBIL supply 5 parts: grouped under the catalog's "SAE 75W-140" designation — the notes column spells out what sets them apart. A representative part number is MOBIL 102490.
In the SAE 75W-90 grade, VALVOLINE and MOBIL supply 7 parts: grouped under the catalog's "SAE 75W-90" designation — the notes column spells out what sets them apart. A representative part number is MOBIL 104361.
Universal Joint
Heavy Duty
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOOG | 295 | 🇺🇸 US 🇨🇦 CA | Super StrengthGreasable | View on Amazon |
Standard Replacement
| Brand | Part Number | Markets | Notes | Buy |
|---|---|---|---|---|
| MOOG | 330 | 🇺🇸 US 🇨🇦 CA | Greasable | View on Amazon |
Buying Drivetrain Parts for a 2025 Ford E-350
On this vehicle, the drivetrain system moves power from transmission to wheels through axles, CV joints, driveshafts, differentials and wheel-end hardware.
- Confirm you have the 7.3L V8 engine — every part on this page is matched to it.
- Read the notes on each row for position, trim and spec qualifiers before you order.
- Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
- Cross-reference the manufacturer part number against your old part or a service-manual listing.
Start with the largest groups on this page: Gear Oil and Drive Shaft Center Support Bearing .
Frequently Asked Questions
How many drivetrain parts fit the 2025 Ford E-350?
Our catalog currently lists 24 drivetrain parts for the 2025 Ford E-350 across 8 subcategories and 7 brands, covering the 7.3L V8 engine. Each part is matched to the engine(s) it fits.
What are the signs of drivetrain problems on a 2025 Ford E-350?
Common symptoms include clicking in tight turns, a clunk when shifting between drive and reverse, vibration that builds with speed, or gear oil on the inside of a wheel. If you notice any of these, identify the affected subcategory above and cross-reference the part numbers listed.
What should I replace at the same time?
Where labor overlaps, replace the differential or transfer-case fluid with any axle or seal job while everything is already open.
What do the market flags (US, CA, MX) on each part mean?
They show the market for which the manufacturer published application data for that part — where the vehicle was first sold, not where the part was made. If your 2025 Ford E-350 was originally sold in the US, the safest choice is a part marked for the US market.
How do I make sure a part fits my 2025 Ford E-350?
Every part on this page is matched to the 7.3L V8 engine. Then a torn CV boot caught early is a cheap boot kit; caught late it is a whole axle — inspect before deciding which to buy. The notes column carries position and trim qualifiers where they apply.
Other Parts for the 2025 Ford E-350
Drivetrain Parts for Other Ford E-350 Years
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Manufacturer names, model designations and part numbers are used for identification and fitment reference only. AutoFactsDB is an independent catalog and is not affiliated with, endorsed by, or sponsored by any vehicle manufacturer displayed on this page.